Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections

• Published in: Infection and immunity Vol. 84; no. 2; pp. 416 - 424
• Main Authors: Chella Krishnan, Karthickeyan, Mukundan, Santhosh, Alagarsamy, Jeyashree, Laturnus, Donna, Kotb, Malak
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.02.2016
• Subjects: Animals; Bacterial Load; Disease Models, Animal; Disease Susceptibility; Female; Genetic Predisposition to Disease; Genetic Variation; Host Response and Inflammation; Host-Pathogen Interactions; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Sex Characteristics; Soft Tissue Infections - genetics; Soft Tissue Infections - microbiology; Streptococcal Infections - genetics; Streptococcal Infections - microbiology; Streptococcus; Streptococcus pyogenes - growth & development; Streptococcus pyogenes - pathogenicity

Host genetic variations play an important role in several pathogenic diseases, and we previously provided strong evidence that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive group A Streptococcus (GAS) patients, including sepsis a...