Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

• Published in: Neuron (Cambridge, Mass.) Vol. 107; no. 4; pp. 684 - 702.e9
• Main Authors: Brignani, Sara, Raj, Divya D.A., Schmidt, Ewoud R.E., Düdükcü, Özge, Adolfs, Youri, De Ruiter, Anna A., Rybiczka-Tesulov, Mateja, Verhagen, Marieke G., van der Meer, Christiaan, Broekhoven, Mark H., Moreno-Bravo, Juan A., Grossouw, Laurens M., Dumontier, Emilie, Cloutier, Jean-François, Chédotal, Alain, Pasterkamp, R. Jeroen
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 19.08.2020; Elsevier Limited
• Subjects: Artificial chromosomes; Brain; Cell adhesion & migration; development; dopamine neuron; Dopamine receptors; fluorescent light sheet microscopy; Forebrain; GABAergic neuron; Gene expression; guidance cue; intersectional genetics; Labeling; Mesencephalon; migration; Morphology; Movement disorders; Netrin-1; Neurodegenerative diseases; neuronal subtype; Neurons; Parkinson's disease; Physiology; Substantia nigra; γ-Aminobutyric acid; substantia nigra; development; guidance cue; Netrin-1; dopamine neuron; migration; GABAergic neuron; intersectional genetics; fluorescent light sheet microscopy; neuronal subtype

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in Parkinson’s disease. Despite progress in identifying mDA neuron subtypes, how these neuronal subsets develop and...