Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis

• Published in: Journal of dairy science Vol. 107; no. 12; pp. 10611 - 10627
• Main Authors: Fan, Yunhui, Ma, Li, Fang, Xinxin, Du, Shuyu, Mauck, John, Loor, Juan J., Sun, Xudong, Jia, Hongdou, Xu, Chuang, Xu, Qiushi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2024; Elsevier
• Subjects: adipocytes; adipose tissue; Adipose Tissue - metabolism; Animals; basic-leucine zipper transcription factors; blood serum; bovine adipocytes; catalase; Cattle; Cattle Diseases - metabolism; dairy science; energy balance; family; Female; Ferroptosis; glutamate-cysteine ligase; glutathione; heme oxygenase (biliverdin-producing); HIF-1α; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; iron; ketosis; Ketosis - metabolism; Ketosis - veterinary; Lipid Peroxidation; lipids; lipolysis; long-chain-fatty-acid-CoA ligase; malondialdehyde; monogastric livestock; Oxidative Stress; phospholipid-hydroperoxide glutathione peroxidase; protein subunits; protein synthesis; reactive oxygen species; RNA; solutes; superoxide dismutase; HIF-1α; ferroptosis; bovine adipocytes; oxidative stress

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Postpartum cows experience lipolysis in adipose tissue due to negative energy balance, and accumulation of free fatty acids leads to metabolic stress in adi...