Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs

• Published in: Chemistry and physics of lipids Vol. 243; p. 105178
• Main Authors: Pei, Yihua, Bao, Yanjie, Sacchetti, Cristiano, Brady, Juthamart, Gillard, Kyra, Yu, Hailong, Roberts, Scott, Rajappan, Kumar, Tanis, Steven P., Perez-Garcia, Carlos G., Chivukula, Padmanabh, Karmali, Priya P.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2022
• Subjects: Cationic lipids; DOTAP; Humans; Lipid nanoparticles; Liposomes - chemistry; LNP; Lung; mRNA; Nanoparticles - chemistry; Nebulization; Research Paper; RNA, Messenger - administration & dosage; Lung; Cationic lipids; mRNA; Nebulization; DOTAP; Lipid nanoparticles; LNP

Lipid nanoparticles (LNPs) mediated mRNA delivery has gained prominence due to the success of mRNA vaccines against Covid-19, without which it would not have been possible. However, there is little clinical validation of this technology for other mRNA-based therapeutic approaches. Systemic administr...