Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation

• Published in: The Journal of biological chemistry Vol. 274; no. 45; pp. 32512 - 32519
• Main Authors: Blair, Alison, Shaul, Philip W., Yuhanna, Ivan S., Conrad, Patricia A., Smart, Eric J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.11.1999; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Cell Membrane - drug effects; Cell Membrane - enzymology; Cells, Cultured; Cholesterol - metabolism; Cyclodextrins - pharmacology; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Lipoproteins, HDL - metabolism; Lipoproteins, LDL - metabolism; Myristic Acid - metabolism; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type III; Palmitic Acid - metabolism; Phosphorylation; Swine

Hypercholesterolemia-induced vascular disease and atherosclerosis are characterized by a decrease in the bioavailability of endothelium-derived nitric oxide. Endothelial nitric-oxide synthase (eNOS) associates with caveolae and is directly regulated by the caveola protein, caveolin. In the present s...