Priming of Metabolic Dysfunctions by Prenatal Immune Activation in Mice: Relevance to Schizophrenia

• Published in: Schizophrenia bulletin Vol. 39; no. 2; pp. 319 - 329
• Main Authors: Pacheco-López, Gustavo, Giovanoli, Sandra, Langhans, Wolfgang, Meyer, Urs
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2013
• Subjects: Acute-Phase Reaction - immunology; Adult and adolescent clinical studies; Animals; Biological and medical sciences; Body Composition; Corticosterone - blood; Cytokines - immunology; Disease Models, Animal; Female; Glucose Intolerance - immunology; Hyperphagia - immunology; Male; Medical sciences; Mice; Mice, Inbred C57BL; Polynucleotides - pharmacology; Pregnancy; Pregnancy Complications, Infectious - immunology; Prenatal Exposure Delayed Effects - immunology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Regular; Schizophrenia; Schizophrenia - immunology; maternal infection; Priming effect; Rodentia; Cytokine; immune activation; Schizophrenia; Metabolic diseases; Cognition; Activation; metabolic disease; Psychosis; Infection; Prenatal; Vertebrata; Metabolic disorder; Mammalia; Mouse; obesitypoly(I:C); Animal; cytokines

Schizophrenia is associated with increased risk for multiple metabolic abnormalities, including altered glucose homeostasis, type-2 diabetes, obesity, and cardiovascular disease. Some of the metabolic alterations can already exist in psychosis-prone subjects prior to the onset of chronic schizophren...