Hyaluronic Acid-Based Nanocarriers for Anticancer Drug Delivery

Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural l...

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Published inPolymers Vol. 15; no. 10; p. 2317
Main Authors Fu, Chao-Ping, Cai, Xing-Yu, Chen, Si-Lin, Yu, Hong-Wei, Fang, Ying, Feng, Xiao-Chen, Zhang, Li-Ming, Li, Chang-Yong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.05.2023
MDPI
Subjects
Aqueous solutions
Biocompatibility
Breast cancer
Cancer therapies
Carbon nanotubes
Chemotherapy
Cytotoxicity
Design optimization
Drug carriers
Drug delivery systems
Drugs
Gene therapy
Health aspects
Hyaluronic acid
Hydrogels
Hydroxyl groups
Laboratory animals
Ligands
Metastasis
Micelles
Molecular structure
Nanocrystals
Nanomaterials
Nanoparticles
Nanotubes
Ovarian cancer
Quantum dots
Review
Silica
Silicon dioxide
Toxicity
Tumors
Vehicles
China
anticancer drug carriers
drug delivery
prodrugs
hyaluronic acid
Online AccessGet full text
ISSN2073-4360
2073-4360
DOI10.3390/polym15102317

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Abstract Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ligand for tumor-targeted drug delivery systems, as it contains the endocytic HA receptor, CD44, which is overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed to improve drug delivery efficiency and distinguish between healthy and cancerous tissues, resulting in reduced residual toxicity and off-target accumulation. This article comprehensively reviews the fabrication of anticancer drug nanocarriers based on HA in the context of prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles and hydrogels) and inorganic composite nanocarriers (gold nanoparticles, quantum dots, carbon nanotubes and silicon dioxide). Additionally, the progress achieved in the design and optimization of these nanocarriers and their effects on cancer therapy are discussed. Finally, the review provides a summary of the perspectives, the lessons learned so far and the outlook towards further developments in this field.
AbstractList Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ligand for tumor-targeted drug delivery systems, as it contains the endocytic HA receptor, CD44, which is overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed to improve drug delivery efficiency and distinguish between healthy and cancerous tissues, resulting in reduced residual toxicity and off-target accumulation. This article comprehensively reviews the fabrication of anticancer drug nanocarriers based on HA in the context of prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles and hydrogels) and inorganic composite nanocarriers (gold nanoparticles, quantum dots, carbon nanotubes and silicon dioxide). Additionally, the progress achieved in the design and optimization of these nanocarriers and their effects on cancer therapy are discussed. Finally, the review provides a summary of the perspectives, the lessons learned so far and the outlook towards further developments in this field.
Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ligand for tumor-targeted drug delivery systems, as it contains the endocytic HA receptor, CD44, which is overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed to improve drug delivery efficiency and distinguish between healthy and cancerous tissues, resulting in reduced residual toxicity and off-target accumulation. This article comprehensively reviews the fabrication of anticancer drug nanocarriers based on HA in the context of prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles and hydrogels) and inorganic composite nanocarriers (gold nanoparticles, quantum dots, carbon nanotubes and silicon dioxide). Additionally, the progress achieved in the design and optimization of these nanocarriers and their effects on cancer therapy are discussed. Finally, the review provides a summary of the perspectives, the lessons learned so far and the outlook towards further developments in this field.Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ligand for tumor-targeted drug delivery systems, as it contains the endocytic HA receptor, CD44, which is overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed to improve drug delivery efficiency and distinguish between healthy and cancerous tissues, resulting in reduced residual toxicity and off-target accumulation. This article comprehensively reviews the fabrication of anticancer drug nanocarriers based on HA in the context of prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles and hydrogels) and inorganic composite nanocarriers (gold nanoparticles, quantum dots, carbon nanotubes and silicon dioxide). Additionally, the progress achieved in the design and optimization of these nanocarriers and their effects on cancer therapy are discussed. Finally, the review provides a summary of the perspectives, the lessons learned so far and the outlook towards further developments in this field.
Audience Academic
Author Fu, Chao-Ping
Feng, Xiao-Chen
Zhang, Li-Ming
Li, Chang-Yong
Fang, Ying
Yu, Hong-Wei
Cai, Xing-Yu
Chen, Si-Lin
AuthorAffiliation 3 State Key Laboratory of Molecular Engineering of Polymers (Fudan University), Shanghai 200438, China
2 College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, China
4 School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China
1 Institute of Biomaterials and Tissue Engineering & Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, China
AuthorAffiliation_xml – name: 4 School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China
– name: 1 Institute of Biomaterials and Tissue Engineering & Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, China
– name: 3 State Key Laboratory of Molecular Engineering of Polymers (Fudan University), Shanghai 200438, China
– name: 2 College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, China
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  orcidid: 0000-0002-4757-6889
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37242892$$D View this record in MEDLINE/PubMed
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Snippet Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility,...
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SubjectTerms Aqueous solutions
Biocompatibility
Breast cancer
Cancer therapies
Carbon nanotubes
Chemotherapy
Cytotoxicity
Design optimization
Drug carriers
Drug delivery systems
Drugs
Gene therapy
Health aspects
Hyaluronic acid
Hydrogels
Hydroxyl groups
Laboratory animals
Ligands
Metastasis
Micelles
Molecular structure
Nanocrystals
Nanomaterials
Nanoparticles
Nanotubes
Ovarian cancer
Quantum dots
Review
Silica
Silicon dioxide
Toxicity
Tumors
Vehicles
Title Hyaluronic Acid-Based Nanocarriers for Anticancer Drug Delivery
URI https://www.ncbi.nlm.nih.gov/pubmed/37242892
https://www.proquest.com/docview/2819479266
https://www.proquest.com/docview/2820020359
https://pubmed.ncbi.nlm.nih.gov/PMC10224391
Volume 15
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