Biomarkers in connective tissue diseases

Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate diagnosis, monitoring disease activity and progression, selecting therapeutics, and assessing treatment response. Because of their correlations...

Full description

Saved in:
Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 140; no. 6; pp. 1473 - 1483
Main Authors Jog, Neelakshi R., James, Judith A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2017
Elsevier Limited
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate diagnosis, monitoring disease activity and progression, selecting therapeutics, and assessing treatment response. Because of their correlations with specific clinical characteristics and often with disease progression, autoantibodies and other soluble mediators are considered potential biomarkers. Additional biomarkers might reflect downstream pathologic processes or appear because of ongoing inflammation and damage. Because of overlap between diseases, some biomarkers have limited specificity for a single autoimmune connective tissue disease. This review describes select current biomarkers that aid in the diagnosis and treatment of several major systemic autoimmune connective tissue disorders: systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody–associated vasculitides. Newly proposed biomarkers that target various stages in disease onset or progression are also discussed. Newer approaches to overcome the diversity observed in patients with these diseases and to facilitate personalized disease monitoring and treatment are also addressed.
AbstractList Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate diagnosis, monitoring disease activity and progression, selecting therapeutics, and assessing treatment response. Because of their correlations with specific clinical characteristics and often with disease progression, autoantibodies and other soluble mediators are considered potential biomarkers. Additional biomarkers might reflect downstream pathologic processes or appear because of ongoing inflammation and damage. Because of overlap between diseases, some biomarkers have limited specificity for a single autoimmune connective tissue disease. This review describes select current biomarkers that aid in the diagnosis and treatment of several major systemic autoimmune connective tissue disorders: systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody–associated vasculitides. Newly proposed biomarkers that target various stages in disease onset or progression are also discussed. Newer approaches to overcome the diversity observed in patients with these diseases and to facilitate personalized disease monitoring and treatment are also addressed.
Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate diagnosis, monitoring disease activity and progression, selecting therapeutics, and assessing treatment response. Because of their correlations with specific clinical characteristics and often with disease progression, autoantibodies and other soluble mediators are considered potential biomarkers. Additional biomarkers may reflect downstream pathological processes or may appear due to ongoing inflammation and damage. Because of overlap between diseases, some biomarkers have limited specificity for a single autoimmune connective tissue disease. This review describes select current biomarkers that aid in diagnosis and treatment of several major systemic autoimmune connective tissue disorders: systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and ANCA-associated vasculitides. Newly proposed biomarkers that target various stages in disease onset or progression are also discussed. Newer approaches to overcome the diversity observed in these diseases and to facilitate personalized disease monitoring and treatment are also addressed.
Author Jog, Neelakshi R.
James, Judith A.
AuthorAffiliation 2 Oklahoma Clinical and Translational Science Institute, University of Oklahoma Health Sciences Center; Departments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
1 Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104
AuthorAffiliation_xml – name: 1 Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104
– name: 2 Oklahoma Clinical and Translational Science Institute, University of Oklahoma Health Sciences Center; Departments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
Author_xml – sequence: 1
  givenname: Neelakshi R.
  surname: Jog
  fullname: Jog, Neelakshi R.
  organization: Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Okla
– sequence: 2
  givenname: Judith A.
  surname: James
  fullname: James, Judith A.
  email: jamesj@omrf.org
  organization: Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Okla
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29221579$$D View this record in MEDLINE/PubMed
BookMark eNp9kU9LJDEQxYO46PjnC3iQAS9z6dlKMul0QAQVdReEveyeQzpdrWlnEk26B_z2ph0V9bCnkKpfPare2yPbPngk5IjCnAItf3bzzlg3Z0BlLswB-BaZUFCyKCsmtskEQNGilAu1S_ZS6iD_eaV2yC5TjFEh1YTMLlxYmfiAMU2dn9rgPdrerXHau5QGnDYuoUmYDsiP1iwTHr69--Tf9dXfy1_F7Z-b35fnt4VdVLwvDBoQdS0rU9qWssYIK6WFRc1rBlZao6iqDVRVyQWwlivZ2rJWyEUFaMqa75Ozje7jUK-wsej7aJb6Mbq85rMOxumvHe_u9V1Ya1FRJQVkgdmbQAxPA6Zer1yyuFwaj2FI-pVialGKjJ58Q7swRJ_PGylOs0VMZoptKBtDShHbj2Uo6DEI3ekxCD0GMdZyEHno-PMZHyPvzmfgdANgNnPtMOpkHXqLjYs5Ad0E9z_9F_Icmy4
CitedBy_id crossref_primary_10_1002_art_41566
crossref_primary_10_1371_journal_pone_0247256
crossref_primary_10_1007_s13555_023_00952_w
crossref_primary_10_2147_JIR_S379815
crossref_primary_10_12677_ACM_2023_134844
crossref_primary_10_1177_09612033211040366
crossref_primary_10_1111_bjd_21627
crossref_primary_10_1073_pnas_2217452119
crossref_primary_10_14412_1996_7012_2019_1_11_18
crossref_primary_10_1136_ard_2021_221926
crossref_primary_10_1007_s10787_021_00812_z
crossref_primary_10_1111_ene_15628
crossref_primary_10_1371_journal_pone_0241189
crossref_primary_10_5694_mja2_12103
crossref_primary_10_1002_hep_32591
crossref_primary_10_14412_1995_4484_2019_3_40
crossref_primary_10_33590_emj_10310605
crossref_primary_10_1007_s00418_018_1659_8
crossref_primary_10_1038_s41584_018_0005_9
crossref_primary_10_3390_jpm12030426
crossref_primary_10_14412_1995_4484_2019_8_16
crossref_primary_10_3389_fimmu_2023_1096096
crossref_primary_10_1016_j_clindermatol_2020_12_013
crossref_primary_10_1016_j_msard_2019_101452
crossref_primary_10_1111_odi_13145
crossref_primary_10_1088_1612_202X_abe7df
crossref_primary_10_3389_fpsyt_2023_1308245
crossref_primary_10_1016_j_coph_2018_07_005
crossref_primary_10_1515_cclm_2018_0066
Cites_doi 10.1136/annrheumdis-2013-203923
10.1177/0961203316644331
10.3899/jrheum.120725
10.1136/lupus-2014-000056
10.3899/jrheum.101086
10.1371/journal.pone.0180144
10.1186/ar3258
10.1136/annrheumdis-2015-207911
10.1002/art.10092
10.1016/j.ebiom.2017.01.033
10.1038/nm0302-295
10.1002/art.39814
10.1080/08916930400022715
10.1093/eurheartj/ehi891
10.2215/CJN.01910213
10.1002/art.40065
10.1002/art.34473
10.1021/pr500780a
10.3899/jrheum.150998
10.1136/ard.2010.146456
10.1038/ki.2010.472
10.1186/ar2821
10.1038/nature13835
10.1038/nrrheum.2014.6
10.3109/03009742.2012.754937
10.1097/BOR.0000000000000356
10.1186/ar1149
10.1007/s10157-013-0926-1
10.1016/j.jim.2015.12.003
10.1073/pnas.0337679100
10.1002/art.37995
10.1002/art.34380
10.1038/nrrheum.2014.104
10.1155/2012/606195
10.3899/jrheum.140767
10.1016/j.autrev.2015.12.002
10.1136/ard.2008.093146
10.1002/art.30560
10.1016/j.jaut.2017.07.003
10.1093/rheumatology/ker280
10.2215/CJN.01020113
10.1186/ar3813
10.1007/s10067-013-2305-4
10.1016/j.ajhg.2017.06.001
10.1002/art.1780331210
10.1016/j.jaut.2008.12.002
10.1002/eji.201646810
10.1002/art.40004
10.1016/j.semarthrit.2005.03.005
10.1186/ar122
10.1016/j.autrev.2008.06.010
10.3899/jrheum.090019
10.1002/art.20862
10.1177/0961203309105529
10.1002/art.27678
10.1074/mcp.M112.021667
10.1002/art.27638
10.1172/JCI36389
10.1056/NEJMoa1114576
10.1186/ar4486
10.1378/chest.10-0302
10.1136/ard.2011.155382
10.5114/reum.2016.61212
10.1002/art.22356
10.3109/s10165-011-0568-7
10.5152/eurjrheum.2017.16006
10.1136/annrheumdis-2013-205013
10.1002/art.24586
10.1136/ard.2009.116384
10.1186/ar2825
10.1186/ar3927
10.1002/art.23678
10.1177/0961203316676386
10.1016/j.cell.2016.03.008
10.1002/art.34669
10.1002/art.38573
10.1002/art.40066
10.1002/art.22198
10.7326/0003-4819-146-11-200706050-00008
10.1111/j.1365-2222.2011.03943.x
10.1002/art.30598
10.1136/ard.45.5.359
10.1080/08820139.2017.1288236
10.1002/acr.21930
10.1002/art.20120
10.1136/annrheumdis-2011-201109
10.1016/j.jaut.2016.06.001
10.1016/S0923-1811(01)00128-1
10.1016/j.jbspin.2014.06.001
10.1016/j.rmed.2013.03.015
10.1186/ar551
10.1002/art.21031
10.1016/0002-9343(75)90259-4
10.1002/art.38241
10.1038/sj.gene.6364408
10.1371/journal.pmed.0030491
10.1016/S0140-6736(17)30933-9
10.5114/reum.2016.62470
10.1002/art.1780400928
10.1111/cei.12796
10.1046/j.1523-1755.2000.00080.x
10.1002/art.20044
10.1136/ard.2007.082099
10.1002/art.1780251101
10.1093/rheumatology/keu413
10.1056/NEJMoa021933
10.1186/ar2816
10.1093/rheumatology/keq445
10.1056/NEJM199805073381906
10.3899/jrheum.110071
10.1136/annrheumdis-2015-208140
10.1016/j.jaut.2016.12.005
10.1136/ard.2006.054445
10.1002/art.34426
10.1002/art.40207
10.1186/ar3912
10.1016/j.autrev.2014.12.004
ContentType Journal Article
Copyright 2017 American Academy of Allergy, Asthma & Immunology
Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Copyright Elsevier Science Ltd. Dec 1, 2017
Copyright_xml – notice: 2017 American Academy of Allergy, Asthma & Immunology
– notice: Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
– notice: Copyright Elsevier Science Ltd. Dec 1, 2017
DBID NPM
AAYXX
CITATION
7SS
7T5
H94
K9.
NAPCQ
7X8
5PM
DOI 10.1016/j.jaci.2017.10.003
DatabaseName PubMed
CrossRef
Entomology Abstracts (Full archive)
Immunology Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Entomology Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
Immunology Abstracts
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
Entomology Abstracts

PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1097-6825
EndPage 1483
ExternalDocumentID 10_1016_j_jaci_2017_10_003
29221579
S0091674917316433
Genre Journal Article
Review
GrantInformation_xml – fundername: National Institutes of Health
  grantid: U54GM104938; U01AI101934; U19AI082714; P30GM103510; P30AR053483
  funderid: https://doi.org/10.13039/100000002
GroupedDBID ---
--K
--M
-~X
.1-
.55
.FO
.GJ
.XZ
.~1
0R~
1B1
1P~
1RT
1~.
1~5
354
3O-
3V.
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
7RV
7X7
8C1
8F7
8FE
8FH
8P~
9JM
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXUO
ABBQC
ABFNM
ABJNI
ABLJU
ABLVK
ABMAC
ABMZM
ABOCM
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACPRK
ACRLP
ADBBV
ADEZE
ADFRT
ADMUD
AEBSH
AEKER
AENEX
AFFNX
AFKRA
AFKWA
AFRAH
AFRHN
AFTJW
AFXIZ
AGEKW
AGHFR
AGUBO
AGYEJ
AHHHB
AHMBA
AHPSJ
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BBNVY
BENPR
BHPHI
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
C45
CAG
CJTIS
COF
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HCIFZ
HDU
HMK
HMO
HVGLF
HZ~
IHE
J1W
J5H
K-O
KOM
L7B
LCYCR
LK8
LUGTX
M27
M2O
M41
M7P
MO0
N4W
N9A
O-L
O9-
O9~
OAUVE
OBH
ODZKP
OHH
OHT
OK0
OK1
OVD
OZT
P-8
P-9
P2P
PC.
PQQKQ
PROAC
Q38
R2-
RIG
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SEL
SES
SEW
SJN
SPCBC
SSH
SSI
SSZ
T5K
TEORI
TWZ
UGJ
UNMZH
UV1
WH7
WOW
WUQ
X7M
XFW
YOC
YQI
YQJ
Z5R
ZA5
ZGI
ZXP
ZY1
~02
~G-
~KM
AAXKI
ADVLN
AFJKZ
AKRWK
NPM
AAYXX
CITATION
7SS
7T5
H94
K9.
NAPCQ
7X8
5PM
ID FETCH-LOGICAL-c483t-aea05bb78a6cf12da5c77c04b3b20c7ca919ba08863502f397fc6b9e3580ea6b3
IEDL.DBID AIKHN
ISSN 0091-6749
IngestDate Tue Sep 17 21:19:10 EDT 2024
Fri Oct 25 06:51:20 EDT 2024
Thu Oct 10 15:53:58 EDT 2024
Thu Sep 26 15:50:30 EDT 2024
Wed Oct 16 01:00:12 EDT 2024
Fri Feb 23 02:20:18 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords CRP
ILD
LN
SSc
dcSSc
lcSSc
ACPA
MPO
SLE
systemic lupus erythematosus
systemic sclerosis
NT-proBNP
ANCA
BLyS
RNAP III
ACA
SSA
DAS28
Connective tissue diseases
vasculitis
ESR
biomarkers
rheumatoid arthritis
GDF-15
RA
ACR
PR3
CCP
EGPA
ANA
Dlco
RF
AAV
PAH
HES
GPA
Anti-CarP
dsDNA
MPA
Language English
License Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c483t-aea05bb78a6cf12da5c77c04b3b20c7ca919ba08863502f397fc6b9e3580ea6b3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink http://www.jacionline.org/article/S0091674917316433/pdf
PMID 29221579
PQID 1973115727
PQPubID 105664
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5819750
proquest_miscellaneous_1975029465
proquest_journals_1973115727
crossref_primary_10_1016_j_jaci_2017_10_003
pubmed_primary_29221579
elsevier_sciencedirect_doi_10_1016_j_jaci_2017_10_003
PublicationCentury 2000
PublicationDate December 2017
2017-Dec
2017-12-00
20171201
PublicationDateYYYYMMDD 2017-12-01
PublicationDate_xml – month: 12
  year: 2017
  text: December 2017
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: St. Louis
PublicationTitle Journal of allergy and clinical immunology
PublicationTitleAlternate J Allergy Clin Immunol
PublicationYear 2017
Publisher Elsevier Inc
Elsevier Limited
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
References Koenig, Dieude, Senecal (bib85) 2008; 7
Gottenberg, Ravaud, Cantagrel, Combe, Flipo, Schaeverbeke (bib67) 2012; 71
Hahn (bib27) 1998; 338
Brunner, Bennett, Mina, Suzuki, Petri, Kiani (bib47) 2012; 64
Munroe, Vista, Merrill, Guthridge, Roberts, James (bib45) 2017; 78
Jog, Blanco, Lee, Putterman, Caricchio (bib49) 2016; 25
Ng, Manson, Rahman, Isenberg (bib35) 2006; 55
Kawai, Banno, Kikuchi, Nishimura, Nobata, Kimura (bib113) 2014; 18
Takakuwa, Kurokawa, Ooka, Sato, Nagai, Arito (bib111) 2011; 63
Munroe, Lu, Zhao, Fife, Robertson, Guthridge (bib12) 2016; 75
Hesselstrand, Kassner, Heinegard, Saxne (bib93) 2008; 67
Pepper, Draibe, Caplin, Fervenza, Hoffman, Kallenberg (bib120) 2017; 69
Vaglio, Strehl, Manger, Maritati, Alberici, Beyer (bib106) 2012; 71
Niklas, Niklas, Majewski, Puszczewicz (bib5) 2016; 54
Munroe, Vista, Guthridge, Thompson, Merrill, James (bib44) 2014; 66
Gourh, Arnett, Assassi, Tan, Huang, Diekman (bib97) 2009; 11
Gardette, Ottaviani, Tubach, Roy, Nicaise-Roland, Palazzo (bib68) 2014; 81
Kalunian, Chatham, Massarotti, Reyes-Thomas, Harris, Furie (bib40) 2012; 64
England, Thiele, Mikuls (bib65) 2017; 29
Svard, Kastbom, Soderlin, Reckner-Olsson, Skogh (bib69) 2011; 38
Shooshtari, Huang, Cotsapas (bib2) 2017; 101
Turesson, Jacobsson, Sturfelt, Matteson, Mathsson, Ronnelid (bib62) 2007; 66
Steiner, Smolen (bib60) 2002; 4
Tan, Cohen, Fries, Masi, McShane, Rothfield (bib22) 1982; 25
McClain, Arbuckle, Heinlen, Dennis, Roebuck, Rubertone (bib10) 2004; 50
Tony, Roll, Mei, Blumner, Straka, Gnuegge (bib79) 2015; 33
Xu, Wu, Tu, Chu, Zhu, Liang (bib101) 2013; 32
Swaak, Groenwold, Bronsveld (bib39) 1986; 45
Lambrecht, Smith, De Wilde, Coudenys, Decuman, Deforce (bib95) 2014; 66
Maijer, Li, Sasso, Gerlag, Defranoux, Tak (bib78) 2015; 74
Putterman, Furie, Ramsey-Goldman, Askanase, Buyon, Kalunian (bib41) 2014; 1
Hesselstrand, Wildt, Bozovic, Andersson-Sjoland, Andreasson, Scheja (bib102) 2013; 107
Williams, Handler, Akram, Smith, Das, Smee (bib92) 2006; 27
Niewold, Hua, Lehman, Harley, Crow (bib51) 2007; 8
Tseng, Buyon, Kim, Belmont, Mackay, Diamond (bib30) 2006; 54
Gan, Trouw, Shi, Toes, Huizinga, Demoruelle (bib73) 2015; 42
Greco, Rizzo, De Virgilio, Gallo, Fusconi, Ruoppolo (bib104) 2015; 14
Tedeschi, Johnson, Boumpas, Daikh, Dorner, Jayne (bib18) 2017
Sharma, Harris, Cavett, Kurien, Liu, Koelsch (bib6) 2017
Schwartz, Rubinstein, Burkly, Collins, Blanco, Su (bib46) 2009; 11
Sato, Hasegawa, Takehara (bib98) 2001; 27
Deane, El-Gabalawy (bib3) 2014; 10
O'Dell (bib59) 2002; 46
Szczeklik, Sanak, Mastalerz, Sokolowska, Gielicz, Soja (bib108) 2012; 42
Petri, Singh, Tesfasyone, Malik (bib29) 2009; 36
Olsen, Li, Quan, Wang, Mutwally, Karp (bib38) 2012; 14
Eriksson, Rantapaa-Dahlqvist, Sundqvist (bib80) 2013; 42
Zwerina, Bach, Martorana, Jatzwauk, Hegasy, Moosig (bib105) 2011; 50
Shah, Xu, Rosen, Hummers, Wigley, Elledge (bib90) 2017; 69
Wu, Du, Han, Singh, Xie, Guo (bib50) 2013; 12
Baechler, Batliwalla, Karypis, Gaffney, Ortmann, Espe (bib55) 2003; 100
Steen (bib84) 2005; 35
Vossenaar, Despres, Lapointe, van der Heijden, Lora, Senshu (bib71) 2004; 6
Dallos, Heiland, Strehl, Karonitsch, Gross, Moosig (bib107) 2010; 62
Olson, Lee, Prince, Baker, Papadopoulos, Edison (bib28) 2013; 8
Lai, Xue, Liao, Huang, Peng, Huang (bib114) 2017; 46
Kemna, Plomp, van Paassen, Koeleman, Jansen, Damoiseaux (bib119) 2017; 17
Cozzani, Drosera, Gasparini, Parodi (bib21) 2014; 2014
Wuhrer, Stavenhagen, Koeleman, Selman, Harper, Jacobs (bib118) 2015; 14
Hochberg (bib23) 1997; 40
Bardana, Harbeck, Hoffman, Pirofsky, Carr (bib25) 1975; 59
Moinzadeh, Fonseca, Hellmich, Shah, Chighizola, Denton (bib86) 2014; 16
Oliver, Silman (bib7) 2009; 11
Yoshimi, Ueda, Ozato, Ishigatsubo (bib32) 2012; 2012
Farh, Marson, Zhu, Kleinewietfeld, Housley, Beik (bib1) 2015; 518
Zhao, Weinstein, Tuzova, Davidson, Mundel, Marambio (bib26) 2005; 52
Leuchten, Hoyer, Brinks, Schoels, Schneider, Smolen (bib16) 2017
Denton, Khanna (bib83) 2017
Szczeklik, Jakiela, Wawrzycka-Adamczyk, Sanak, Hubalewska-Mazgaj, Padjas (bib122) 2017; 47
Migliorini, Baldini, Rocchi, Bombardieri (bib31) 2005; 38
Petri, van Vollenhoven, Buyon, Levy, Navarra, Cervera (bib43) 2013; 65
Meadows, Risbano, Zhang, Geraci, Tuder, Collier (bib96) 2011; 139
Fritzler (bib20) 2016; 15
van der Woude, Syversen, van der Voort, Verpoort, Goll, van der Linden (bib70) 2010; 69
Paul, Kandy, Krishnan (bib15) 2017; 4
Valoes, Molinari, Pitta, Gormezano, Farhat, Kozu (bib34) 2017; 26
Ritterhouse, Crowe, Niewold, Merrill, Roberts, Dedeke (bib52) 2011; 63
Brennan, McInnes (bib76) 2008; 118
Choi, Gerlag, Herenius, Thurlings, Wijbrandts, Foell (bib81) 2015; 74
Briani, Lucchetta, Ghirardello, Toffanin, Zampieri, Ruggero (bib33) 2009; 32
Vidal-Bralo, Perez-Pampin, Regueiro, Montes, Varela, Boveda (bib74) 2017; 12
Menard, Lapointe, Rochdi, Zhou (bib72) 2000; 2
Yanaba, Hasegawa, Takehara, Sato (bib91) 2004; 31
Lu, Munroe, Guthridge, Bean, Fife, Chen (bib11) 2016; 74
Yanaba, Asano, Tada, Sugaya, Kadono, Sato (bib94) 2012; 22
Kemna, Schlumberger, van Paassen, Dahnrich, Damoiseaux (bib117) 2016; 185
van Bon, Cossu, Loof, Gohar, Wittkowski, Vonk (bib103) 2014; 73
Singh, Wu, Xie, Vanarsa, Han, Mahajan (bib48) 2012; 14
Franssen, Stegeman, Kallenberg, Gans, De Jong, Hoorntje (bib110) 2000; 57
Tomasson, Grayson, Mahr, Lavalley, Merkel (bib116) 2012; 51
Navarro-Compan, Gherghe, Smolen, Aletaha, Landewe, van der Heijde (bib75) 2015; 54
Eriksson, Kokkonen, Johansson, Hallmans, Wadell, Rantapaa-Dahlqvist (bib9) 2011; 13
Demoruelle, Harrall, Ho, Purmalek, Seto, Rothfuss (bib64) 2017; 69
Robinson, DiGennaro, Hueber, Haab, Kamachi, Dean (bib36) 2002; 8
De Lauretis, Sestini, Pantelidis, Hoyles, Hansell, Goh (bib99) 2013; 40
Yazdany, Schmajuk, Robbins, Daikh, Beall, Yelin (bib19) 2013; 65
van Gaalen, Linn-Rasker, van Venrooij, de Jong, Breedveld, Verweij (bib66) 2004; 50
Sharif, Fritzler, Mayes, Gonzalez, McNearney, Draeger (bib88) 2011; 38
Patro, Singh, Misra, Aggarwal (bib82) 2016; 43
Ma, Chang, Gershwin, Lian (bib14) 2017; 83
Petri, Stohl, Chatham, McCune, Chevrier, Ryel (bib42) 2008; 58
de Joode, Sanders, Stegeman (bib112) 2013; 8
Petri, Orbai, Alarcon, Gordon, Merrill, Fortin (bib24) 2012; 64
Petri, Singh, Tesfasyone, Dedrick, Fry, Lal (bib58) 2009; 18
Henes, Chen, Bley, Fabel, Both, Herrmann (bib121) 2011; 70
Banchereau, Hong, Cantarel, Baldwin, Baisch, Edens (bib53) 2016; 165
Putterman, Wu, Reiner-Benaim, Batty, Sanz, Oates (bib37) 2016; 429
Satoh, Chan, Ho, Rose, Parks, Cohn (bib17) 2012; 64
Bauer, Baechler, Petri, Batliwalla, Crawford, Ortmann (bib54) 2006; 3
Fertig, Domsic, Rodriguez-Reyna, Kuwana, Lucas, Medsger (bib89) 2009; 61
Nishimura, Sugiyama, Kogata, Tsuji, Nakazawa, Kawano (bib61) 2007; 146
Deane, O'Donnell, Hueber, Majka, Lazar, Derber (bib77) 2010; 62
Kallenberg (bib109) 2014; 10
Too, Yahya, Murad, Dhaliwal, Larsson, Muhamad (bib63) 2012; 14
Niklas, Niklas, Majewski, Puszczewicz (bib4) 2016; 54
van Bon, Affandi, Broen, Christmann, Marijnissen, Stawski (bib100) 2014; 370
Wilde, van Paassen, Witzke, Tervaert (bib115) 2011; 79
Kirou, Lee, George, Louca, Peterson, Crow (bib56) 2005; 52
Munroe, Young, Kamen, Guthridge, Niewold, Costenbader (bib13) 2017; 69
Landolt-Marticorena, Bonventi, Lubovich, Ferguson, Unnithan, Su (bib57) 2009; 68
Arbuckle, McClain, Rubertone, Scofield, Dennis, James (bib8) 2003; 349
Okano, Medsger (bib87) 1990; 33
Eriksson (10.1016/j.jaci.2017.10.003_bib9) 2011; 13
Petri (10.1016/j.jaci.2017.10.003_bib58) 2009; 18
Koenig (10.1016/j.jaci.2017.10.003_bib85) 2008; 7
Demoruelle (10.1016/j.jaci.2017.10.003_bib64) 2017; 69
Nishimura (10.1016/j.jaci.2017.10.003_bib61) 2007; 146
Cozzani (10.1016/j.jaci.2017.10.003_bib21) 2014; 2014
Zhao (10.1016/j.jaci.2017.10.003_bib26) 2005; 52
Sharif (10.1016/j.jaci.2017.10.003_bib88) 2011; 38
McClain (10.1016/j.jaci.2017.10.003_bib10) 2004; 50
Yoshimi (10.1016/j.jaci.2017.10.003_bib32) 2012; 2012
Meadows (10.1016/j.jaci.2017.10.003_bib96) 2011; 139
Choi (10.1016/j.jaci.2017.10.003_bib81) 2015; 74
Gan (10.1016/j.jaci.2017.10.003_bib73) 2015; 42
Eriksson (10.1016/j.jaci.2017.10.003_bib80) 2013; 42
Arbuckle (10.1016/j.jaci.2017.10.003_bib8) 2003; 349
Munroe (10.1016/j.jaci.2017.10.003_bib44) 2014; 66
Moinzadeh (10.1016/j.jaci.2017.10.003_bib86) 2014; 16
Hesselstrand (10.1016/j.jaci.2017.10.003_bib102) 2013; 107
Valoes (10.1016/j.jaci.2017.10.003_bib34) 2017; 26
Brunner (10.1016/j.jaci.2017.10.003_bib47) 2012; 64
Banchereau (10.1016/j.jaci.2017.10.003_bib53) 2016; 165
De Lauretis (10.1016/j.jaci.2017.10.003_bib99) 2013; 40
Schwartz (10.1016/j.jaci.2017.10.003_bib46) 2009; 11
Tan (10.1016/j.jaci.2017.10.003_bib22) 1982; 25
Petri (10.1016/j.jaci.2017.10.003_bib42) 2008; 58
Kemna (10.1016/j.jaci.2017.10.003_bib119) 2017; 17
Wu (10.1016/j.jaci.2017.10.003_bib50) 2013; 12
Ritterhouse (10.1016/j.jaci.2017.10.003_bib52) 2011; 63
Tomasson (10.1016/j.jaci.2017.10.003_bib116) 2012; 51
Hahn (10.1016/j.jaci.2017.10.003_bib27) 1998; 338
Gardette (10.1016/j.jaci.2017.10.003_bib68) 2014; 81
Swaak (10.1016/j.jaci.2017.10.003_bib39) 1986; 45
Kalunian (10.1016/j.jaci.2017.10.003_bib40) 2012; 64
van Gaalen (10.1016/j.jaci.2017.10.003_bib66) 2004; 50
Gottenberg (10.1016/j.jaci.2017.10.003_bib67) 2012; 71
Lu (10.1016/j.jaci.2017.10.003_bib11) 2016; 74
Menard (10.1016/j.jaci.2017.10.003_bib72) 2000; 2
Jog (10.1016/j.jaci.2017.10.003_bib49) 2016; 25
Maijer (10.1016/j.jaci.2017.10.003_bib78) 2015; 74
Zwerina (10.1016/j.jaci.2017.10.003_bib105) 2011; 50
Vidal-Bralo (10.1016/j.jaci.2017.10.003_bib74) 2017; 12
Tedeschi (10.1016/j.jaci.2017.10.003_bib18) 2017
Kawai (10.1016/j.jaci.2017.10.003_bib113) 2014; 18
de Joode (10.1016/j.jaci.2017.10.003_bib112) 2013; 8
Dallos (10.1016/j.jaci.2017.10.003_bib107) 2010; 62
Tony (10.1016/j.jaci.2017.10.003_bib79) 2015; 33
Paul (10.1016/j.jaci.2017.10.003_bib15) 2017; 4
Yanaba (10.1016/j.jaci.2017.10.003_bib94) 2012; 22
Petri (10.1016/j.jaci.2017.10.003_bib29) 2009; 36
Kallenberg (10.1016/j.jaci.2017.10.003_bib109) 2014; 10
Kirou (10.1016/j.jaci.2017.10.003_bib56) 2005; 52
van der Woude (10.1016/j.jaci.2017.10.003_bib70) 2010; 69
Leuchten (10.1016/j.jaci.2017.10.003_bib16) 2017
Sato (10.1016/j.jaci.2017.10.003_bib98) 2001; 27
Yanaba (10.1016/j.jaci.2017.10.003_bib91) 2004; 31
Steen (10.1016/j.jaci.2017.10.003_bib84) 2005; 35
Satoh (10.1016/j.jaci.2017.10.003_bib17) 2012; 64
Henes (10.1016/j.jaci.2017.10.003_bib121) 2011; 70
Niklas (10.1016/j.jaci.2017.10.003_bib5) 2016; 54
Singh (10.1016/j.jaci.2017.10.003_bib48) 2012; 14
Baechler (10.1016/j.jaci.2017.10.003_bib55) 2003; 100
Franssen (10.1016/j.jaci.2017.10.003_bib110) 2000; 57
Kemna (10.1016/j.jaci.2017.10.003_bib117) 2016; 185
O'Dell (10.1016/j.jaci.2017.10.003_bib59) 2002; 46
Deane (10.1016/j.jaci.2017.10.003_bib77) 2010; 62
Pepper (10.1016/j.jaci.2017.10.003_bib120) 2017; 69
Ma (10.1016/j.jaci.2017.10.003_bib14) 2017; 83
Greco (10.1016/j.jaci.2017.10.003_bib104) 2015; 14
Wuhrer (10.1016/j.jaci.2017.10.003_bib118) 2015; 14
Hochberg (10.1016/j.jaci.2017.10.003_bib23) 1997; 40
Munroe (10.1016/j.jaci.2017.10.003_bib13) 2017; 69
Landolt-Marticorena (10.1016/j.jaci.2017.10.003_bib57) 2009; 68
Farh (10.1016/j.jaci.2017.10.003_bib1) 2015; 518
Briani (10.1016/j.jaci.2017.10.003_bib33) 2009; 32
Hesselstrand (10.1016/j.jaci.2017.10.003_bib93) 2008; 67
Gourh (10.1016/j.jaci.2017.10.003_bib97) 2009; 11
van Bon (10.1016/j.jaci.2017.10.003_bib103) 2014; 73
Sharma (10.1016/j.jaci.2017.10.003_bib6) 2017
Shooshtari (10.1016/j.jaci.2017.10.003_bib2) 2017; 101
Putterman (10.1016/j.jaci.2017.10.003_bib41) 2014; 1
Bauer (10.1016/j.jaci.2017.10.003_bib54) 2006; 3
Patro (10.1016/j.jaci.2017.10.003_bib82) 2016; 43
Lai (10.1016/j.jaci.2017.10.003_bib114) 2017; 46
Deane (10.1016/j.jaci.2017.10.003_bib3) 2014; 10
Steiner (10.1016/j.jaci.2017.10.003_bib60) 2002; 4
Turesson (10.1016/j.jaci.2017.10.003_bib62) 2007; 66
Takakuwa (10.1016/j.jaci.2017.10.003_bib111) 2011; 63
Szczeklik (10.1016/j.jaci.2017.10.003_bib122) 2017; 47
Too (10.1016/j.jaci.2017.10.003_bib63) 2012; 14
England (10.1016/j.jaci.2017.10.003_bib65) 2017; 29
Lambrecht (10.1016/j.jaci.2017.10.003_bib95) 2014; 66
Svard (10.1016/j.jaci.2017.10.003_bib69) 2011; 38
Vossenaar (10.1016/j.jaci.2017.10.003_bib71) 2004; 6
Yazdany (10.1016/j.jaci.2017.10.003_bib19) 2013; 65
Munroe (10.1016/j.jaci.2017.10.003_bib45) 2017; 78
Brennan (10.1016/j.jaci.2017.10.003_bib76) 2008; 118
Williams (10.1016/j.jaci.2017.10.003_bib92) 2006; 27
Okano (10.1016/j.jaci.2017.10.003_bib87) 1990; 33
Tseng (10.1016/j.jaci.2017.10.003_bib30) 2006; 54
Munroe (10.1016/j.jaci.2017.10.003_bib12) 2016; 75
Xu (10.1016/j.jaci.2017.10.003_bib101) 2013; 32
Shah (10.1016/j.jaci.2017.10.003_bib90) 2017; 69
Petri (10.1016/j.jaci.2017.10.003_bib24) 2012; 64
Robinson (10.1016/j.jaci.2017.10.003_bib36) 2002; 8
van Bon (10.1016/j.jaci.2017.10.003_bib100) 2014; 370
Oliver (10.1016/j.jaci.2017.10.003_bib7) 2009; 11
Petri (10.1016/j.jaci.2017.10.003_bib43) 2013; 65
Fritzler (10.1016/j.jaci.2017.10.003_bib20) 2016; 15
Bardana (10.1016/j.jaci.2017.10.003_bib25) 1975; 59
Niewold (10.1016/j.jaci.2017.10.003_bib51) 2007; 8
Olsen (10.1016/j.jaci.2017.10.003_bib38) 2012; 14
Navarro-Compan (10.1016/j.jaci.2017.10.003_bib75) 2015; 54
Ng (10.1016/j.jaci.2017.10.003_bib35) 2006; 55
Niklas (10.1016/j.jaci.2017.10.003_bib4) 2016; 54
Szczeklik (10.1016/j.jaci.2017.10.003_bib108) 2012; 42
Vaglio (10.1016/j.jaci.2017.10.003_bib106) 2012; 71
Denton (10.1016/j.jaci.2017.10.003_bib83) 2017
Putterman (10.1016/j.jaci.2017.10.003_bib37) 2016; 429
Fertig (10.1016/j.jaci.2017.10.003_bib89) 2009; 61
Wilde (10.1016/j.jaci.2017.10.003_bib115) 2011; 79
Olson (10.1016/j.jaci.2017.10.003_bib28) 2013; 8
Migliorini (10.1016/j.jaci.2017.10.003_bib31) 2005; 38
References_xml – volume: 42
  start-page: 572
  year: 2015
  end-page: 579
  ident: bib73
  article-title: Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis
  publication-title: J Rheumatol
  contributor:
    fullname: Demoruelle
– volume: 38
  start-page: 1265
  year: 2011
  end-page: 1272
  ident: bib69
  article-title: A comparison between IgG- and IgA-class antibodies to cyclic citrullinated peptides and to modified citrullinated vimentin in early rheumatoid arthritis and very early arthritis
  publication-title: J Rheumatol
  contributor:
    fullname: Skogh
– volume: 36
  start-page: 2476
  year: 2009
  end-page: 2480
  ident: bib29
  article-title: Prevalence of flare and influence of demographic and serologic factors on flare risk in systemic lupus erythematosus: a prospective study
  publication-title: J Rheumatol
  contributor:
    fullname: Malik
– volume: 15
  start-page: 272
  year: 2016
  end-page: 280
  ident: bib20
  article-title: Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing
  publication-title: Autoimmun Rev
  contributor:
    fullname: Fritzler
– volume: 14
  start-page: R174
  year: 2012
  ident: bib38
  article-title: Autoantibody profiling to follow evolution of lupus syndromes
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Karp
– volume: 71
  start-page: 390
  year: 2012
  end-page: 393
  ident: bib106
  article-title: IgG4 immune response in Churg-Strauss syndrome
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Beyer
– volume: 101
  start-page: 75
  year: 2017
  end-page: 86
  ident: bib2
  article-title: Integrative genetic and epigenetic analysis uncovers regulatory mechanisms of autoimmune disease
  publication-title: Am J Hum Genet
  contributor:
    fullname: Cotsapas
– volume: 64
  start-page: 2677
  year: 2012
  end-page: 2686
  ident: bib24
  article-title: Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Fortin
– volume: 81
  start-page: 416
  year: 2014
  end-page: 420
  ident: bib68
  article-title: High anti-CCP antibody titres predict good response to rituximab in patients with active rheumatoid arthritis
  publication-title: Joint Bone Spine
  contributor:
    fullname: Palazzo
– volume: 11
  start-page: R147
  year: 2009
  ident: bib97
  article-title: Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Diekman
– volume: 50
  start-page: 709
  year: 2004
  end-page: 715
  ident: bib66
  article-title: Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study
  publication-title: Arthritis Rheum
  contributor:
    fullname: Verweij
– volume: 66
  start-page: 59
  year: 2007
  end-page: 64
  ident: bib62
  article-title: Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Ronnelid
– volume: 62
  start-page: 3161
  year: 2010
  end-page: 3172
  ident: bib77
  article-title: The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner
  publication-title: Arthritis Rheum
  contributor:
    fullname: Derber
– volume: 74
  start-page: 499
  year: 2015
  end-page: 505
  ident: bib81
  article-title: MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Foell
– volume: 185
  start-page: 141
  year: 2016
  end-page: 147
  ident: bib117
  article-title: Cohen Tervaert JW. The avidity of PR3-ANCA in patients with granulomatosis with polyangiitis during follow-up
  publication-title: Clin Exp Immunol
  contributor:
    fullname: Damoiseaux
– volume: 17
  start-page: 108
  year: 2017
  end-page: 118
  ident: bib119
  article-title: Galactosylation and sialylation levels of IgG predict relapse in patients with PR3-ANCA associated vasculitis
  publication-title: EBioMedicine
  contributor:
    fullname: Damoiseaux
– volume: 6
  start-page: R142
  year: 2004
  end-page: R150
  ident: bib71
  article-title: Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Senshu
– volume: 61
  start-page: 958
  year: 2009
  end-page: 965
  ident: bib89
  article-title: Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Medsger
– volume: 45
  start-page: 359
  year: 1986
  end-page: 366
  ident: bib39
  article-title: Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Bronsveld
– volume: 52
  start-page: 1491
  year: 2005
  end-page: 1503
  ident: bib56
  article-title: Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
  publication-title: Arthritis Rheum
  contributor:
    fullname: Crow
– volume: 338
  start-page: 1359
  year: 1998
  end-page: 1368
  ident: bib27
  article-title: Antibodies to DNA
  publication-title: N Engl J Med
  contributor:
    fullname: Hahn
– year: 2017
  ident: bib6
  article-title: Rare X chromosome abnormalities in systemic lupus erythematosus and Sjogren's syndrome
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Koelsch
– volume: 8
  start-page: 492
  year: 2007
  end-page: 502
  ident: bib51
  article-title: High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus
  publication-title: Genes Immun
  contributor:
    fullname: Crow
– volume: 69
  start-page: 630
  year: 2017
  end-page: 642
  ident: bib13
  article-title: Discerning risk of disease transition in relatives of systemic lupus erythematosus patients utilizing soluble mediators and clinical features
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Costenbader
– volume: 118
  start-page: 3537
  year: 2008
  end-page: 3545
  ident: bib76
  article-title: Evidence that cytokines play a role in rheumatoid arthritis
  publication-title: J Clin Invest
  contributor:
    fullname: McInnes
– volume: 52
  start-page: 522
  year: 2005
  end-page: 530
  ident: bib26
  article-title: Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential
  publication-title: Arthritis Rheum
  contributor:
    fullname: Marambio
– volume: 32
  start-page: 1501
  year: 2013
  end-page: 1510
  ident: bib101
  article-title: Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities
  publication-title: Clin Rheumatol
  contributor:
    fullname: Liang
– volume: 46
  start-page: 283
  year: 2002
  end-page: 285
  ident: bib59
  article-title: Treating rheumatoid arthritis early: a window of opportunity?
  publication-title: Arthritis Rheum
  contributor:
    fullname: O'Dell
– volume: 78
  start-page: 70
  year: 2017
  end-page: 78
  ident: bib45
  article-title: Pathways of impending disease flare in African-American systemic lupus erythematosus patients
  publication-title: J Autoimmun
  contributor:
    fullname: James
– volume: 69
  start-page: 1165
  year: 2017
  end-page: 1175
  ident: bib64
  article-title: Anti-citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Rothfuss
– volume: 349
  start-page: 1526
  year: 2003
  end-page: 1533
  ident: bib8
  article-title: Development of autoantibodies before the clinical onset of systemic lupus erythematosus
  publication-title: N Engl J Med
  contributor:
    fullname: James
– volume: 14
  start-page: R164
  year: 2012
  ident: bib48
  article-title: Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Mahajan
– volume: 12
  start-page: e0180144
  year: 2017
  ident: bib74
  article-title: Anti-carbamylated protein autoantibodies associated with mortality in Spanish rheumatoid arthritis patients
  publication-title: PLoS One
  contributor:
    fullname: Boveda
– volume: 370
  start-page: 433
  year: 2014
  end-page: 443
  ident: bib100
  article-title: Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
  publication-title: N Engl J Med
  contributor:
    fullname: Stawski
– volume: 50
  start-page: 1226
  year: 2004
  end-page: 1232
  ident: bib10
  article-title: The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Rubertone
– volume: 54
  start-page: 165
  year: 2016
  end-page: 169
  ident: bib5
  article-title: Rheumatic diseases induced by drugs and environmental factors: the state-of-the-art—part two
  publication-title: Reumatologia
  contributor:
    fullname: Puszczewicz
– volume: 79
  start-page: 599
  year: 2011
  end-page: 612
  ident: bib115
  article-title: New pathophysiological insights and treatment of ANCA-associated vasculitis
  publication-title: Kidney Int
  contributor:
    fullname: Tervaert
– volume: 165
  start-page: 551
  year: 2016
  end-page: 565
  ident: bib53
  article-title: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
  publication-title: Cell
  contributor:
    fullname: Edens
– volume: 64
  start-page: 4040
  year: 2012
  end-page: 4047
  ident: bib40
  article-title: Measurement of cell-bound complement activation products enhances diagnostic performance in systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Furie
– volume: 31
  start-page: 1112
  year: 2004
  end-page: 1120
  ident: bib91
  article-title: Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis
  publication-title: J Rheumatol
  contributor:
    fullname: Sato
– volume: 13
  start-page: R30
  year: 2011
  ident: bib9
  article-title: Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Rantapaa-Dahlqvist
– volume: 59
  start-page: 515
  year: 1975
  end-page: 522
  ident: bib25
  article-title: The prognostic and therapeutic implications of DNA:anti-DNA immune complexes in systemic lupus erythematosus (SLE)
  publication-title: Am J Med
  contributor:
    fullname: Carr
– volume: 63
  start-page: 3931
  year: 2011
  end-page: 3941
  ident: bib52
  article-title: B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels
  publication-title: Arthritis Rheum
  contributor:
    fullname: Dedeke
– volume: 139
  start-page: 994
  year: 2011
  end-page: 1002
  ident: bib96
  article-title: Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension
  publication-title: Chest
  contributor:
    fullname: Collier
– volume: 55
  start-page: 900
  year: 2006
  end-page: 904
  ident: bib35
  article-title: Association of antinucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Isenberg
– volume: 2012
  start-page: 606195
  year: 2012
  ident: bib32
  article-title: Clinical and pathological roles of Ro/SSA autoantibody system
  publication-title: Clin Dev Immunol
  contributor:
    fullname: Ishigatsubo
– volume: 22
  start-page: 668
  year: 2012
  end-page: 675
  ident: bib94
  article-title: Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis: association with disease severity
  publication-title: Mod Rheumatol
  contributor:
    fullname: Sato
– volume: 54
  start-page: 122
  year: 2016
  end-page: 127
  ident: bib4
  article-title: Rheumatic diseases induced by drugs and environmental factors: the state-of-the-art—part one
  publication-title: Reumatologia
  contributor:
    fullname: Puszczewicz
– volume: 65
  start-page: 2143
  year: 2013
  end-page: 2153
  ident: bib43
  article-title: Baseline predictors of systemic lupus erythematosus flares: data from the combined placebo groups in the phase III belimumab trials
  publication-title: Arthritis Rheum
  contributor:
    fullname: Cervera
– volume: 58
  start-page: 2453
  year: 2008
  end-page: 2459
  ident: bib42
  article-title: Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Ryel
– volume: 74
  start-page: 182
  year: 2016
  end-page: 193
  ident: bib11
  article-title: Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies
  publication-title: J Autoimmun
  contributor:
    fullname: Chen
– volume: 8
  start-page: 1702
  year: 2013
  end-page: 1708
  ident: bib28
  article-title: Elevated subclinical double-stranded DNA antibodies and future proliferative lupus nephritis
  publication-title: Clin J Am Soc Nephrol
  contributor:
    fullname: Edison
– volume: 71
  start-page: 1815
  year: 2012
  end-page: 1819
  ident: bib67
  article-title: Positivity for anti-cyclic citrullinated peptide is associated with a better response to abatacept: data from the ‘Orencia and Rheumatoid Arthritis’ registry
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Schaeverbeke
– volume: 10
  start-page: 212
  year: 2014
  end-page: 228
  ident: bib3
  article-title: Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: El-Gabalawy
– volume: 26
  start-page: 484
  year: 2017
  end-page: 489
  ident: bib34
  article-title: Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients
  publication-title: Lupus
  contributor:
    fullname: Kozu
– volume: 46
  start-page: 375
  year: 2017
  end-page: 384
  ident: bib114
  article-title: Differential expression of toll-like receptor signaling pathway is associated with microscopic polyangiitis in peripheral blood neutrophils
  publication-title: Immunol Invest
  contributor:
    fullname: Huang
– volume: 66
  start-page: 1888
  year: 2014
  end-page: 1899
  ident: bib44
  article-title: Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: James
– volume: 27
  start-page: 140
  year: 2001
  end-page: 146
  ident: bib98
  article-title: Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
  publication-title: J Dermatol Sci
  contributor:
    fullname: Takehara
– volume: 47
  start-page: 724
  year: 2017
  end-page: 733
  ident: bib122
  article-title: Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis
  publication-title: Eur J Immunol
  contributor:
    fullname: Padjas
– volume: 54
  start-page: 994
  year: 2015
  end-page: 1007
  ident: bib75
  article-title: Relationship between disease activity indices and their individual components and radiographic progression in RA: a systematic literature review
  publication-title: Rheumatology (Oxford)
  contributor:
    fullname: van der Heijde
– volume: 67
  start-page: 1242
  year: 2008
  end-page: 1248
  ident: bib93
  article-title: COMP: a candidate molecule in the pathogenesis of systemic sclerosis with a potential as a disease marker
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Saxne
– volume: 66
  start-page: 418
  year: 2014
  end-page: 427
  ident: bib95
  article-title: Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Deforce
– volume: 518
  start-page: 337
  year: 2015
  end-page: 343
  ident: bib1
  article-title: Genetic and epigenetic fine mapping of causal autoimmune disease variants
  publication-title: Nature
  contributor:
    fullname: Beik
– volume: 29
  start-page: 57
  year: 2017
  end-page: 64
  ident: bib65
  article-title: Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis
  publication-title: Curr Opin Rheumatol
  contributor:
    fullname: Mikuls
– volume: 11
  start-page: R143
  year: 2009
  ident: bib46
  article-title: Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Su
– volume: 42
  start-page: 260
  year: 2013
  end-page: 265
  ident: bib80
  article-title: Changes in chemokines and their receptors in blood during treatment with the TNF inhibitor infliximab in patients with rheumatoid arthritis
  publication-title: Scand J Rheumatol
  contributor:
    fullname: Sundqvist
– volume: 11
  start-page: 252
  year: 2009
  ident: bib7
  article-title: Why are women predisposed to autoimmune rheumatic diseases?
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Silman
– volume: 33
  start-page: 887
  year: 2015
  end-page: 894
  ident: bib79
  article-title: Combination of B cell biomarkers as independent predictors of response in patients with rheumatoid arthritis treated with rituximab
  publication-title: Clin Exp Rheumatol
  contributor:
    fullname: Gnuegge
– volume: 2014
  start-page: 321359
  year: 2014
  ident: bib21
  article-title: Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects
  publication-title: Autoimmune Dis
  contributor:
    fullname: Parodi
– volume: 69
  start-page: 1306
  year: 2017
  end-page: 1312
  ident: bib90
  article-title: Brief report: anti-RNPC-3 antibodies as a marker of cancer-associated scleroderma
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Elledge
– volume: 25
  start-page: 1271
  year: 1982
  end-page: 1277
  ident: bib22
  article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Rothfield
– volume: 8
  start-page: 295
  year: 2002
  end-page: 301
  ident: bib36
  article-title: Autoantigen microarrays for multiplex characterization of autoantibody responses
  publication-title: Nat Med
  contributor:
    fullname: Dean
– volume: 69
  start-page: 1110
  year: 2010
  end-page: 1116
  ident: bib70
  article-title: The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: van der Linden
– volume: 27
  start-page: 1485
  year: 2006
  end-page: 1494
  ident: bib92
  article-title: Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension
  publication-title: Eur Heart J
  contributor:
    fullname: Smee
– volume: 73
  start-page: 1585
  year: 2014
  end-page: 1589
  ident: bib103
  article-title: Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Vonk
– volume: 42
  start-page: 513
  year: 2012
  end-page: 522
  ident: bib108
  article-title: 12-hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome
  publication-title: Clin Exp Allergy
  contributor:
    fullname: Soja
– volume: 8
  start-page: 1709
  year: 2013
  end-page: 1717
  ident: bib112
  article-title: Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis
  publication-title: Clin J Am Soc Nephrol
  contributor:
    fullname: Stegeman
– volume: 62
  start-page: 3496
  year: 2010
  end-page: 3503
  ident: bib107
  article-title: CCL17/thymus and activation-related chemokine in Churg-Strauss syndrome
  publication-title: Arthritis Rheum
  contributor:
    fullname: Moosig
– volume: 16
  start-page: R53
  year: 2014
  ident: bib86
  article-title: Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Denton
– year: 2017
  ident: bib83
  article-title: Systemic sclerosis
  publication-title: Lancet
  contributor:
    fullname: Khanna
– volume: 2
  start-page: 429
  year: 2000
  end-page: 432
  ident: bib72
  article-title: Insights into rheumatoid arthritis derived from the Sa immune system
  publication-title: Arthritis Res
  contributor:
    fullname: Zhou
– volume: 51
  start-page: 100
  year: 2012
  end-page: 109
  ident: bib116
  article-title: Value of ANCA measurements during remission to predict a relapse of ANCA-associated vasculitis—a meta-analysis
  publication-title: Rheumatology (Oxford)
  contributor:
    fullname: Merkel
– volume: 74
  start-page: 2097
  year: 2015
  end-page: 2099
  ident: bib78
  article-title: Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Tak
– volume: 429
  start-page: 1
  year: 2016
  end-page: 6
  ident: bib37
  article-title: SLE-key((R)) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: developing the ImmunArray iCHIP((R))
  publication-title: J Immunol Methods
  contributor:
    fullname: Oates
– volume: 12
  start-page: 1170
  year: 2013
  end-page: 1179
  ident: bib50
  article-title: Urinary angiostatin—a novel putative marker of renal pathology chronicity in lupus nephritis
  publication-title: Mol Cell Proteomics
  contributor:
    fullname: Guo
– volume: 50
  start-page: 1823
  year: 2011
  end-page: 1827
  ident: bib105
  article-title: Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study
  publication-title: Rheumatology (Oxford)
  contributor:
    fullname: Moosig
– year: 2017
  ident: bib16
  article-title: Performance of anti-nuclear antibodies for classifying systemic lupus erythematosus: a systematic literature review and meta-regression of diagnostic data
  publication-title: Arthritis Care Res (Hoboken)
  contributor:
    fullname: Smolen
– volume: 68
  start-page: 1440
  year: 2009
  end-page: 1446
  ident: bib57
  article-title: Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Su
– volume: 14
  start-page: R89
  year: 2012
  ident: bib63
  article-title: Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Muhamad
– volume: 146
  start-page: 797
  year: 2007
  end-page: 808
  ident: bib61
  article-title: Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis
  publication-title: Ann Intern Med
  contributor:
    fullname: Kawano
– volume: 18
  start-page: 795
  year: 2014
  end-page: 802
  ident: bib113
  article-title: Retrospective analysis of factors predicting end-stage renal failure or death in patients with microscopic polyangiitis with mainly renal involvement
  publication-title: Clin Exp Nephrol
  contributor:
    fullname: Kimura
– volume: 18
  start-page: 980
  year: 2009
  end-page: 989
  ident: bib58
  article-title: Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus
  publication-title: Lupus
  contributor:
    fullname: Lal
– volume: 14
  start-page: 341
  year: 2015
  end-page: 348
  ident: bib104
  article-title: Churg-Strauss syndrome
  publication-title: Autoimmun Rev
  contributor:
    fullname: Ruoppolo
– volume: 3
  start-page: e491
  year: 2006
  ident: bib54
  article-title: Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus
  publication-title: PLoS Med
  contributor:
    fullname: Ortmann
– volume: 43
  start-page: 731
  year: 2016
  end-page: 737
  ident: bib82
  article-title: Myeloid-related protein 8/14 levels in rheumatoid arthritis: marker of disease activity and response to methotrexate
  publication-title: J Rheumatol
  contributor:
    fullname: Aggarwal
– volume: 25
  start-page: 1551
  year: 2016
  end-page: 1557
  ident: bib49
  article-title: Urinary high-mobility group box-1 associates specifically with lupus nephritis class V
  publication-title: Lupus
  contributor:
    fullname: Caricchio
– year: 2017
  ident: bib18
  article-title: Developing and refining new candidate criteria for SLE classification: an international collaboration
  publication-title: Arthritis Care Res (Hoboken)
  contributor:
    fullname: Jayne
– volume: 40
  start-page: 435
  year: 2013
  end-page: 446
  ident: bib99
  article-title: Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis
  publication-title: J Rheumatol
  contributor:
    fullname: Goh
– volume: 69
  start-page: 185
  year: 2017
  end-page: 193
  ident: bib120
  article-title: Association of serum calprotectin (S100A8/A9) level with disease relapse in proteinase 3-antineutrophil cytoplasmic antibody-associated vasculitis
  publication-title: Arthritis Rheumatol
  contributor:
    fullname: Kallenberg
– volume: 75
  start-page: 2014
  year: 2016
  end-page: 2021
  ident: bib12
  article-title: Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Guthridge
– volume: 63
  start-page: 3613
  year: 2011
  end-page: 3624
  ident: bib111
  article-title: AC13, a C-terminal fragment of apolipoprotein A-I, is a candidate biomarker for microscopic polyangiitis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Arito
– volume: 32
  start-page: 79
  year: 2009
  end-page: 84
  ident: bib33
  article-title: Neurolupus is associated with anti-ribosomal P protein antibodies: an inception cohort study
  publication-title: J Autoimmun
  contributor:
    fullname: Ruggero
– volume: 33
  start-page: 1822
  year: 1990
  end-page: 1828
  ident: bib87
  article-title: Autoantibody to Th ribonucleoprotein (nucleolar 7-2 RNA protein particle) in patients with systemic sclerosis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Medsger
– volume: 35
  start-page: 35
  year: 2005
  end-page: 42
  ident: bib84
  article-title: Autoantibodies in systemic sclerosis
  publication-title: Semin Arthritis Rheum
  contributor:
    fullname: Steen
– volume: 64
  start-page: 2687
  year: 2012
  end-page: 2697
  ident: bib47
  article-title: Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Kiani
– volume: 64
  start-page: 2319
  year: 2012
  end-page: 2327
  ident: bib17
  article-title: Prevalence and sociodemographic correlates of antinuclear antibodies in the United States
  publication-title: Arthritis Rheum
  contributor:
    fullname: Cohn
– volume: 54
  start-page: 3623
  year: 2006
  end-page: 3632
  ident: bib30
  article-title: The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial
  publication-title: Arthritis Rheum
  contributor:
    fullname: Diamond
– volume: 14
  start-page: 1657
  year: 2015
  end-page: 1665
  ident: bib118
  article-title: Skewed Fc glycosylation profiles of anti-proteinase 3 immunoglobulin G1 autoantibodies from granulomatosis with polyangiitis patients show low levels of bisection, galactosylation, and sialylation
  publication-title: J Proteome Res
  contributor:
    fullname: Jacobs
– volume: 40
  start-page: 1725
  year: 1997
  ident: bib23
  article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  contributor:
    fullname: Hochberg
– volume: 65
  start-page: 329
  year: 2013
  end-page: 339
  ident: bib19
  article-title: Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question
  publication-title: Arthritis Care Res (Hoboken)
  contributor:
    fullname: Yelin
– volume: 83
  start-page: 95
  year: 2017
  end-page: 112
  ident: bib14
  article-title: Development of autoantibodies precedes clinical manifestations of autoimmune diseases: a comprehensive review
  publication-title: J Autoimmun
  contributor:
    fullname: Lian
– volume: 38
  start-page: 1622
  year: 2011
  end-page: 1630
  ident: bib88
  article-title: Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis
  publication-title: J Rheumatol
  contributor:
    fullname: Draeger
– volume: 100
  start-page: 2610
  year: 2003
  end-page: 2615
  ident: bib55
  article-title: Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Espe
– volume: 107
  start-page: 1079
  year: 2013
  end-page: 1086
  ident: bib102
  article-title: Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis
  publication-title: Respir Med
  contributor:
    fullname: Scheja
– volume: 57
  start-page: 2195
  year: 2000
  end-page: 2206
  ident: bib110
  article-title: Antiproteinase 3- and antimyeloperoxidase-associated vasculitis
  publication-title: Kidney Int
  contributor:
    fullname: Hoorntje
– volume: 7
  start-page: 588
  year: 2008
  end-page: 593
  ident: bib85
  article-title: Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies
  publication-title: Autoimmun Rev
  contributor:
    fullname: Senecal
– volume: 38
  start-page: 47
  year: 2005
  end-page: 54
  ident: bib31
  article-title: Anti-Sm and anti-RNP antibodies
  publication-title: Autoimmunity
  contributor:
    fullname: Bombardieri
– volume: 10
  start-page: 484
  year: 2014
  end-page: 493
  ident: bib109
  article-title: Key advances in the clinical approach to ANCA-associated vasculitis
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: Kallenberg
– volume: 1
  start-page: e000056
  year: 2014
  ident: bib41
  article-title: Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements
  publication-title: Lupus Sci Med
  contributor:
    fullname: Kalunian
– volume: 4
  start-page: 161
  year: 2017
  end-page: 165
  ident: bib15
  article-title: Pre-rheumatoid arthritis and its prevention
  publication-title: Eur J Rheumatol
  contributor:
    fullname: Krishnan
– volume: 70
  start-page: 1926
  year: 2011
  end-page: 1929
  ident: bib121
  article-title: Correlation of serum level of high mobility group box 1 with the burden of granulomatous inflammation in granulomatosis with polyangiitis (Wegener's)
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Herrmann
– volume: 4
  start-page: S1
  year: 2002
  end-page: S5
  ident: bib60
  article-title: Autoantibodies in rheumatoid arthritis and their clinical significance
  publication-title: Arthritis Res
  contributor:
    fullname: Smolen
– volume: 74
  start-page: 499
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib81
  article-title: MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2013-203923
  contributor:
    fullname: Choi
– volume: 25
  start-page: 1551
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib49
  article-title: Urinary high-mobility group box-1 associates specifically with lupus nephritis class V
  publication-title: Lupus
  doi: 10.1177/0961203316644331
  contributor:
    fullname: Jog
– volume: 40
  start-page: 435
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib99
  article-title: Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.120725
  contributor:
    fullname: De Lauretis
– volume: 1
  start-page: e000056
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib41
  article-title: Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements
  publication-title: Lupus Sci Med
  doi: 10.1136/lupus-2014-000056
  contributor:
    fullname: Putterman
– volume: 38
  start-page: 1265
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib69
  article-title: A comparison between IgG- and IgA-class antibodies to cyclic citrullinated peptides and to modified citrullinated vimentin in early rheumatoid arthritis and very early arthritis
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.101086
  contributor:
    fullname: Svard
– volume: 12
  start-page: e0180144
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib74
  article-title: Anti-carbamylated protein autoantibodies associated with mortality in Spanish rheumatoid arthritis patients
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0180144
  contributor:
    fullname: Vidal-Bralo
– volume: 13
  start-page: R30
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib9
  article-title: Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar3258
  contributor:
    fullname: Eriksson
– volume: 74
  start-page: 2097
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib78
  article-title: Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2015-207911
  contributor:
    fullname: Maijer
– volume: 46
  start-page: 283
  year: 2002
  ident: 10.1016/j.jaci.2017.10.003_bib59
  article-title: Treating rheumatoid arthritis early: a window of opportunity?
  publication-title: Arthritis Rheum
  doi: 10.1002/art.10092
  contributor:
    fullname: O'Dell
– volume: 17
  start-page: 108
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib119
  article-title: Galactosylation and sialylation levels of IgG predict relapse in patients with PR3-ANCA associated vasculitis
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.01.033
  contributor:
    fullname: Kemna
– volume: 8
  start-page: 295
  year: 2002
  ident: 10.1016/j.jaci.2017.10.003_bib36
  article-title: Autoantigen microarrays for multiplex characterization of autoantibody responses
  publication-title: Nat Med
  doi: 10.1038/nm0302-295
  contributor:
    fullname: Robinson
– volume: 69
  start-page: 185
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib120
  article-title: Association of serum calprotectin (S100A8/A9) level with disease relapse in proteinase 3-antineutrophil cytoplasmic antibody-associated vasculitis
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.39814
  contributor:
    fullname: Pepper
– volume: 38
  start-page: 47
  year: 2005
  ident: 10.1016/j.jaci.2017.10.003_bib31
  article-title: Anti-Sm and anti-RNP antibodies
  publication-title: Autoimmunity
  doi: 10.1080/08916930400022715
  contributor:
    fullname: Migliorini
– volume: 27
  start-page: 1485
  year: 2006
  ident: 10.1016/j.jaci.2017.10.003_bib92
  article-title: Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehi891
  contributor:
    fullname: Williams
– volume: 8
  start-page: 1702
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib28
  article-title: Elevated subclinical double-stranded DNA antibodies and future proliferative lupus nephritis
  publication-title: Clin J Am Soc Nephrol
  doi: 10.2215/CJN.01910213
  contributor:
    fullname: Olson
– volume: 69
  start-page: 1306
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib90
  article-title: Brief report: anti-RNPC-3 antibodies as a marker of cancer-associated scleroderma
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.40065
  contributor:
    fullname: Shah
– volume: 64
  start-page: 2677
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib24
  article-title: Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34473
  contributor:
    fullname: Petri
– volume: 14
  start-page: 1657
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib118
  article-title: Skewed Fc glycosylation profiles of anti-proteinase 3 immunoglobulin G1 autoantibodies from granulomatosis with polyangiitis patients show low levels of bisection, galactosylation, and sialylation
  publication-title: J Proteome Res
  doi: 10.1021/pr500780a
  contributor:
    fullname: Wuhrer
– volume: 43
  start-page: 731
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib82
  article-title: Myeloid-related protein 8/14 levels in rheumatoid arthritis: marker of disease activity and response to methotrexate
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.150998
  contributor:
    fullname: Patro
– volume: 70
  start-page: 1926
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib121
  article-title: Correlation of serum level of high mobility group box 1 with the burden of granulomatous inflammation in granulomatosis with polyangiitis (Wegener's)
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.146456
  contributor:
    fullname: Henes
– volume: 79
  start-page: 599
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib115
  article-title: New pathophysiological insights and treatment of ANCA-associated vasculitis
  publication-title: Kidney Int
  doi: 10.1038/ki.2010.472
  contributor:
    fullname: Wilde
– volume: 11
  start-page: R147
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib97
  article-title: Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2821
  contributor:
    fullname: Gourh
– volume: 518
  start-page: 337
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib1
  article-title: Genetic and epigenetic fine mapping of causal autoimmune disease variants
  publication-title: Nature
  doi: 10.1038/nature13835
  contributor:
    fullname: Farh
– volume: 10
  start-page: 212
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib3
  article-title: Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2014.6
  contributor:
    fullname: Deane
– volume: 42
  start-page: 260
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib80
  article-title: Changes in chemokines and their receptors in blood during treatment with the TNF inhibitor infliximab in patients with rheumatoid arthritis
  publication-title: Scand J Rheumatol
  doi: 10.3109/03009742.2012.754937
  contributor:
    fullname: Eriksson
– volume: 29
  start-page: 57
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib65
  article-title: Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0000000000000356
  contributor:
    fullname: England
– volume: 6
  start-page: R142
  year: 2004
  ident: 10.1016/j.jaci.2017.10.003_bib71
  article-title: Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar1149
  contributor:
    fullname: Vossenaar
– volume: 18
  start-page: 795
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib113
  article-title: Retrospective analysis of factors predicting end-stage renal failure or death in patients with microscopic polyangiitis with mainly renal involvement
  publication-title: Clin Exp Nephrol
  doi: 10.1007/s10157-013-0926-1
  contributor:
    fullname: Kawai
– volume: 429
  start-page: 1
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib37
  article-title: SLE-key((R)) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: developing the ImmunArray iCHIP((R))
  publication-title: J Immunol Methods
  doi: 10.1016/j.jim.2015.12.003
  contributor:
    fullname: Putterman
– volume: 100
  start-page: 2610
  year: 2003
  ident: 10.1016/j.jaci.2017.10.003_bib55
  article-title: Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0337679100
  contributor:
    fullname: Baechler
– volume: 65
  start-page: 2143
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib43
  article-title: Baseline predictors of systemic lupus erythematosus flares: data from the combined placebo groups in the phase III belimumab trials
  publication-title: Arthritis Rheum
  doi: 10.1002/art.37995
  contributor:
    fullname: Petri
– volume: 64
  start-page: 2319
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib17
  article-title: Prevalence and sociodemographic correlates of antinuclear antibodies in the United States
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34380
  contributor:
    fullname: Satoh
– volume: 10
  start-page: 484
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib109
  article-title: Key advances in the clinical approach to ANCA-associated vasculitis
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2014.104
  contributor:
    fullname: Kallenberg
– volume: 2012
  start-page: 606195
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib32
  article-title: Clinical and pathological roles of Ro/SSA autoantibody system
  publication-title: Clin Dev Immunol
  doi: 10.1155/2012/606195
  contributor:
    fullname: Yoshimi
– volume: 42
  start-page: 572
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib73
  article-title: Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.140767
  contributor:
    fullname: Gan
– volume: 15
  start-page: 272
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib20
  article-title: Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2015.12.002
  contributor:
    fullname: Fritzler
– volume: 68
  start-page: 1440
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib57
  article-title: Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2008.093146
  contributor:
    fullname: Landolt-Marticorena
– volume: 63
  start-page: 3613
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib111
  article-title: AC13, a C-terminal fragment of apolipoprotein A-I, is a candidate biomarker for microscopic polyangiitis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30560
  contributor:
    fullname: Takakuwa
– volume: 83
  start-page: 95
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib14
  article-title: Development of autoantibodies precedes clinical manifestations of autoimmune diseases: a comprehensive review
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2017.07.003
  contributor:
    fullname: Ma
– volume: 51
  start-page: 100
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib116
  article-title: Value of ANCA measurements during remission to predict a relapse of ANCA-associated vasculitis—a meta-analysis
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ker280
  contributor:
    fullname: Tomasson
– volume: 33
  start-page: 887
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib79
  article-title: Combination of B cell biomarkers as independent predictors of response in patients with rheumatoid arthritis treated with rituximab
  publication-title: Clin Exp Rheumatol
  contributor:
    fullname: Tony
– volume: 8
  start-page: 1709
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib112
  article-title: Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis
  publication-title: Clin J Am Soc Nephrol
  doi: 10.2215/CJN.01020113
  contributor:
    fullname: de Joode
– volume: 14
  start-page: R89
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib63
  article-title: Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar3813
  contributor:
    fullname: Too
– volume: 32
  start-page: 1501
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib101
  article-title: Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-013-2305-4
  contributor:
    fullname: Xu
– volume: 101
  start-page: 75
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib2
  article-title: Integrative genetic and epigenetic analysis uncovers regulatory mechanisms of autoimmune disease
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2017.06.001
  contributor:
    fullname: Shooshtari
– volume: 33
  start-page: 1822
  year: 1990
  ident: 10.1016/j.jaci.2017.10.003_bib87
  article-title: Autoantibody to Th ribonucleoprotein (nucleolar 7-2 RNA protein particle) in patients with systemic sclerosis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780331210
  contributor:
    fullname: Okano
– volume: 32
  start-page: 79
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib33
  article-title: Neurolupus is associated with anti-ribosomal P protein antibodies: an inception cohort study
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2008.12.002
  contributor:
    fullname: Briani
– volume: 47
  start-page: 724
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib122
  article-title: Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201646810
  contributor:
    fullname: Szczeklik
– volume: 69
  start-page: 630
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib13
  article-title: Discerning risk of disease transition in relatives of systemic lupus erythematosus patients utilizing soluble mediators and clinical features
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.40004
  contributor:
    fullname: Munroe
– volume: 35
  start-page: 35
  year: 2005
  ident: 10.1016/j.jaci.2017.10.003_bib84
  article-title: Autoantibodies in systemic sclerosis
  publication-title: Semin Arthritis Rheum
  doi: 10.1016/j.semarthrit.2005.03.005
  contributor:
    fullname: Steen
– volume: 2
  start-page: 429
  year: 2000
  ident: 10.1016/j.jaci.2017.10.003_bib72
  article-title: Insights into rheumatoid arthritis derived from the Sa immune system
  publication-title: Arthritis Res
  doi: 10.1186/ar122
  contributor:
    fullname: Menard
– volume: 7
  start-page: 588
  year: 2008
  ident: 10.1016/j.jaci.2017.10.003_bib85
  article-title: Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2008.06.010
  contributor:
    fullname: Koenig
– volume: 36
  start-page: 2476
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib29
  article-title: Prevalence of flare and influence of demographic and serologic factors on flare risk in systemic lupus erythematosus: a prospective study
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.090019
  contributor:
    fullname: Petri
– volume: 52
  start-page: 522
  year: 2005
  ident: 10.1016/j.jaci.2017.10.003_bib26
  article-title: Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential
  publication-title: Arthritis Rheum
  doi: 10.1002/art.20862
  contributor:
    fullname: Zhao
– volume: 18
  start-page: 980
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib58
  article-title: Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus
  publication-title: Lupus
  doi: 10.1177/0961203309105529
  contributor:
    fullname: Petri
– volume: 62
  start-page: 3496
  year: 2010
  ident: 10.1016/j.jaci.2017.10.003_bib107
  article-title: CCL17/thymus and activation-related chemokine in Churg-Strauss syndrome
  publication-title: Arthritis Rheum
  doi: 10.1002/art.27678
  contributor:
    fullname: Dallos
– volume: 12
  start-page: 1170
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib50
  article-title: Urinary angiostatin—a novel putative marker of renal pathology chronicity in lupus nephritis
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M112.021667
  contributor:
    fullname: Wu
– volume: 62
  start-page: 3161
  year: 2010
  ident: 10.1016/j.jaci.2017.10.003_bib77
  article-title: The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner
  publication-title: Arthritis Rheum
  doi: 10.1002/art.27638
  contributor:
    fullname: Deane
– volume: 31
  start-page: 1112
  year: 2004
  ident: 10.1016/j.jaci.2017.10.003_bib91
  article-title: Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis
  publication-title: J Rheumatol
  contributor:
    fullname: Yanaba
– volume: 118
  start-page: 3537
  year: 2008
  ident: 10.1016/j.jaci.2017.10.003_bib76
  article-title: Evidence that cytokines play a role in rheumatoid arthritis
  publication-title: J Clin Invest
  doi: 10.1172/JCI36389
  contributor:
    fullname: Brennan
– volume: 370
  start-page: 433
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib100
  article-title: Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1114576
  contributor:
    fullname: van Bon
– volume: 16
  start-page: R53
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib86
  article-title: Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar4486
  contributor:
    fullname: Moinzadeh
– volume: 139
  start-page: 994
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib96
  article-title: Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension
  publication-title: Chest
  doi: 10.1378/chest.10-0302
  contributor:
    fullname: Meadows
– volume: 71
  start-page: 390
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib106
  article-title: IgG4 immune response in Churg-Strauss syndrome
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2011.155382
  contributor:
    fullname: Vaglio
– volume: 54
  start-page: 122
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib4
  article-title: Rheumatic diseases induced by drugs and environmental factors: the state-of-the-art—part one
  publication-title: Reumatologia
  doi: 10.5114/reum.2016.61212
  contributor:
    fullname: Niklas
– volume: 55
  start-page: 900
  year: 2006
  ident: 10.1016/j.jaci.2017.10.003_bib35
  article-title: Association of antinucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.22356
  contributor:
    fullname: Ng
– volume: 22
  start-page: 668
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib94
  article-title: Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis: association with disease severity
  publication-title: Mod Rheumatol
  doi: 10.3109/s10165-011-0568-7
  contributor:
    fullname: Yanaba
– volume: 4
  start-page: 161
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib15
  article-title: Pre-rheumatoid arthritis and its prevention
  publication-title: Eur J Rheumatol
  doi: 10.5152/eurjrheum.2017.16006
  contributor:
    fullname: Paul
– volume: 73
  start-page: 1585
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib103
  article-title: Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2013-205013
  contributor:
    fullname: van Bon
– volume: 61
  start-page: 958
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib89
  article-title: Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.24586
  contributor:
    fullname: Fertig
– volume: 69
  start-page: 1110
  year: 2010
  ident: 10.1016/j.jaci.2017.10.003_bib70
  article-title: The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2009.116384
  contributor:
    fullname: van der Woude
– volume: 11
  start-page: 252
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib7
  article-title: Why are women predisposed to autoimmune rheumatic diseases?
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2825
  contributor:
    fullname: Oliver
– volume: 14
  start-page: R174
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib38
  article-title: Autoantibody profiling to follow evolution of lupus syndromes
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar3927
  contributor:
    fullname: Olsen
– volume: 58
  start-page: 2453
  year: 2008
  ident: 10.1016/j.jaci.2017.10.003_bib42
  article-title: Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.23678
  contributor:
    fullname: Petri
– volume: 26
  start-page: 484
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib34
  article-title: Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients
  publication-title: Lupus
  doi: 10.1177/0961203316676386
  contributor:
    fullname: Valoes
– volume: 165
  start-page: 551
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib53
  article-title: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
  publication-title: Cell
  doi: 10.1016/j.cell.2016.03.008
  contributor:
    fullname: Banchereau
– volume: 64
  start-page: 4040
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib40
  article-title: Measurement of cell-bound complement activation products enhances diagnostic performance in systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34669
  contributor:
    fullname: Kalunian
– volume: 66
  start-page: 1888
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib44
  article-title: Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.38573
  contributor:
    fullname: Munroe
– volume: 69
  start-page: 1165
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib64
  article-title: Anti-citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.40066
  contributor:
    fullname: Demoruelle
– volume: 54
  start-page: 3623
  year: 2006
  ident: 10.1016/j.jaci.2017.10.003_bib30
  article-title: The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial
  publication-title: Arthritis Rheum
  doi: 10.1002/art.22198
  contributor:
    fullname: Tseng
– volume: 146
  start-page: 797
  year: 2007
  ident: 10.1016/j.jaci.2017.10.003_bib61
  article-title: Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-146-11-200706050-00008
  contributor:
    fullname: Nishimura
– volume: 42
  start-page: 513
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib108
  article-title: 12-hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome
  publication-title: Clin Exp Allergy
  doi: 10.1111/j.1365-2222.2011.03943.x
  contributor:
    fullname: Szczeklik
– volume: 63
  start-page: 3931
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib52
  article-title: B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30598
  contributor:
    fullname: Ritterhouse
– volume: 45
  start-page: 359
  year: 1986
  ident: 10.1016/j.jaci.2017.10.003_bib39
  article-title: Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.45.5.359
  contributor:
    fullname: Swaak
– volume: 46
  start-page: 375
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib114
  article-title: Differential expression of toll-like receptor signaling pathway is associated with microscopic polyangiitis in peripheral blood neutrophils
  publication-title: Immunol Invest
  doi: 10.1080/08820139.2017.1288236
  contributor:
    fullname: Lai
– volume: 65
  start-page: 329
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib19
  article-title: Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question
  publication-title: Arthritis Care Res (Hoboken)
  doi: 10.1002/acr.21930
  contributor:
    fullname: Yazdany
– volume: 50
  start-page: 1226
  year: 2004
  ident: 10.1016/j.jaci.2017.10.003_bib10
  article-title: The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.20120
  contributor:
    fullname: McClain
– volume: 71
  start-page: 1815
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib67
  article-title: Positivity for anti-cyclic citrullinated peptide is associated with a better response to abatacept: data from the ‘Orencia and Rheumatoid Arthritis’ registry
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2011-201109
  contributor:
    fullname: Gottenberg
– volume: 74
  start-page: 182
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib11
  article-title: Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2016.06.001
  contributor:
    fullname: Lu
– year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib18
  article-title: Developing and refining new candidate criteria for SLE classification: an international collaboration
  publication-title: Arthritis Care Res (Hoboken)
  contributor:
    fullname: Tedeschi
– volume: 27
  start-page: 140
  year: 2001
  ident: 10.1016/j.jaci.2017.10.003_bib98
  article-title: Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
  publication-title: J Dermatol Sci
  doi: 10.1016/S0923-1811(01)00128-1
  contributor:
    fullname: Sato
– year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib16
  article-title: Performance of anti-nuclear antibodies for classifying systemic lupus erythematosus: a systematic literature review and meta-regression of diagnostic data
  publication-title: Arthritis Care Res (Hoboken)
  contributor:
    fullname: Leuchten
– volume: 81
  start-page: 416
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib68
  article-title: High anti-CCP antibody titres predict good response to rituximab in patients with active rheumatoid arthritis
  publication-title: Joint Bone Spine
  doi: 10.1016/j.jbspin.2014.06.001
  contributor:
    fullname: Gardette
– volume: 107
  start-page: 1079
  year: 2013
  ident: 10.1016/j.jaci.2017.10.003_bib102
  article-title: Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis
  publication-title: Respir Med
  doi: 10.1016/j.rmed.2013.03.015
  contributor:
    fullname: Hesselstrand
– volume: 4
  start-page: S1
  issue: suppl 2
  year: 2002
  ident: 10.1016/j.jaci.2017.10.003_bib60
  article-title: Autoantibodies in rheumatoid arthritis and their clinical significance
  publication-title: Arthritis Res
  doi: 10.1186/ar551
  contributor:
    fullname: Steiner
– volume: 52
  start-page: 1491
  year: 2005
  ident: 10.1016/j.jaci.2017.10.003_bib56
  article-title: Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21031
  contributor:
    fullname: Kirou
– volume: 59
  start-page: 515
  year: 1975
  ident: 10.1016/j.jaci.2017.10.003_bib25
  article-title: The prognostic and therapeutic implications of DNA:anti-DNA immune complexes in systemic lupus erythematosus (SLE)
  publication-title: Am J Med
  doi: 10.1016/0002-9343(75)90259-4
  contributor:
    fullname: Bardana
– volume: 66
  start-page: 418
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib95
  article-title: Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.38241
  contributor:
    fullname: Lambrecht
– volume: 8
  start-page: 492
  year: 2007
  ident: 10.1016/j.jaci.2017.10.003_bib51
  article-title: High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus
  publication-title: Genes Immun
  doi: 10.1038/sj.gene.6364408
  contributor:
    fullname: Niewold
– volume: 3
  start-page: e491
  year: 2006
  ident: 10.1016/j.jaci.2017.10.003_bib54
  article-title: Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.0030491
  contributor:
    fullname: Bauer
– year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib83
  article-title: Systemic sclerosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)30933-9
  contributor:
    fullname: Denton
– volume: 54
  start-page: 165
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib5
  article-title: Rheumatic diseases induced by drugs and environmental factors: the state-of-the-art—part two
  publication-title: Reumatologia
  doi: 10.5114/reum.2016.62470
  contributor:
    fullname: Niklas
– volume: 2014
  start-page: 321359
  year: 2014
  ident: 10.1016/j.jaci.2017.10.003_bib21
  article-title: Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects
  publication-title: Autoimmune Dis
  contributor:
    fullname: Cozzani
– volume: 40
  start-page: 1725
  year: 1997
  ident: 10.1016/j.jaci.2017.10.003_bib23
  article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780400928
  contributor:
    fullname: Hochberg
– volume: 185
  start-page: 141
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib117
  article-title: Cohen Tervaert JW. The avidity of PR3-ANCA in patients with granulomatosis with polyangiitis during follow-up
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12796
  contributor:
    fullname: Kemna
– volume: 57
  start-page: 2195
  year: 2000
  ident: 10.1016/j.jaci.2017.10.003_bib110
  article-title: Antiproteinase 3- and antimyeloperoxidase-associated vasculitis
  publication-title: Kidney Int
  doi: 10.1046/j.1523-1755.2000.00080.x
  contributor:
    fullname: Franssen
– volume: 50
  start-page: 709
  year: 2004
  ident: 10.1016/j.jaci.2017.10.003_bib66
  article-title: Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study
  publication-title: Arthritis Rheum
  doi: 10.1002/art.20044
  contributor:
    fullname: van Gaalen
– volume: 67
  start-page: 1242
  year: 2008
  ident: 10.1016/j.jaci.2017.10.003_bib93
  article-title: COMP: a candidate molecule in the pathogenesis of systemic sclerosis with a potential as a disease marker
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2007.082099
  contributor:
    fullname: Hesselstrand
– volume: 25
  start-page: 1271
  year: 1982
  ident: 10.1016/j.jaci.2017.10.003_bib22
  article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780251101
  contributor:
    fullname: Tan
– volume: 54
  start-page: 994
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib75
  article-title: Relationship between disease activity indices and their individual components and radiographic progression in RA: a systematic literature review
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keu413
  contributor:
    fullname: Navarro-Compan
– volume: 349
  start-page: 1526
  year: 2003
  ident: 10.1016/j.jaci.2017.10.003_bib8
  article-title: Development of autoantibodies before the clinical onset of systemic lupus erythematosus
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa021933
  contributor:
    fullname: Arbuckle
– volume: 11
  start-page: R143
  year: 2009
  ident: 10.1016/j.jaci.2017.10.003_bib46
  article-title: Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2816
  contributor:
    fullname: Schwartz
– volume: 50
  start-page: 1823
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib105
  article-title: Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keq445
  contributor:
    fullname: Zwerina
– volume: 338
  start-page: 1359
  year: 1998
  ident: 10.1016/j.jaci.2017.10.003_bib27
  article-title: Antibodies to DNA
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199805073381906
  contributor:
    fullname: Hahn
– volume: 38
  start-page: 1622
  year: 2011
  ident: 10.1016/j.jaci.2017.10.003_bib88
  article-title: Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.110071
  contributor:
    fullname: Sharif
– volume: 75
  start-page: 2014
  year: 2016
  ident: 10.1016/j.jaci.2017.10.003_bib12
  article-title: Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2015-208140
  contributor:
    fullname: Munroe
– volume: 78
  start-page: 70
  year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib45
  article-title: Pathways of impending disease flare in African-American systemic lupus erythematosus patients
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2016.12.005
  contributor:
    fullname: Munroe
– volume: 66
  start-page: 59
  year: 2007
  ident: 10.1016/j.jaci.2017.10.003_bib62
  article-title: Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2006.054445
  contributor:
    fullname: Turesson
– volume: 64
  start-page: 2687
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib47
  article-title: Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34426
  contributor:
    fullname: Brunner
– year: 2017
  ident: 10.1016/j.jaci.2017.10.003_bib6
  article-title: Rare X chromosome abnormalities in systemic lupus erythematosus and Sjogren's syndrome
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.40207
  contributor:
    fullname: Sharma
– volume: 14
  start-page: R164
  year: 2012
  ident: 10.1016/j.jaci.2017.10.003_bib48
  article-title: Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar3912
  contributor:
    fullname: Singh
– volume: 14
  start-page: 341
  year: 2015
  ident: 10.1016/j.jaci.2017.10.003_bib104
  article-title: Churg-Strauss syndrome
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2014.12.004
  contributor:
    fullname: Greco
SSID ssj0009389
Score 2.4447486
SecondaryResourceType review_article
Snippet Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate...
SourceID pubmedcentral
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1473
SubjectTerms Accreditation
Allergies
Antigens
Arthritis
Autoantibodies
Autoimmune diseases
Bioindicators
Biomarkers
Classification
Connective tissue diseases
Copyright
Diagnosis
Disease
Health education
Health risks
Immunoglobulins
Lupus
Medical prognosis
Medical research
Medical treatment
Rheumatoid arthritis
Rheumatology
Scleroderma
Systemic lupus erythematosus
Systemic sclerosis
vasculitis
Title Biomarkers in connective tissue diseases
URI https://dx.doi.org/10.1016/j.jaci.2017.10.003
https://www.ncbi.nlm.nih.gov/pubmed/29221579
https://www.proquest.com/docview/1973115727
https://search.proquest.com/docview/1975029465
https://pubmed.ncbi.nlm.nih.gov/PMC5819750
Volume 140
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS8MwFD5sE8QX8W69UcEHQerW5tY8TlGm4p4U9laSLMEO7MY2X_3tJm06naIPPjaX0nxpTr5wvnMCcIYNtQcuwyOqhjTCRKJIJAhFRopYc6VSVgYKP_Zp7xnfD8igAdd1LIyTVXrbX9n00lr7krZHsz3Jcxfjy52E3p43kOX8CDVhxW5HGLdgpXv30Ot_5t5FacWCeRy5Dj52ppJ5jYTKncKLXZYiL_Tb_vSTf36XUX7Zl243YN0TyrBbffMmNHSxBauP3mW-DedX-fjVaXCmszAvQuWELaWNC-cl5qF30cx24Pn25um6F_nrESKFUzSPhBYdIiVLBVUmToaCKMZUB0skk45iSvCYS2GtiOUUncRY4mEUlVw7x6cWVKJdaBXjQu9DGGPtqKIwGFFsEiKYsVRgiC0_Q1pzE8BFDUo2qbJgZLU8bJQ5CDMHoSuzEAZAatyypbnMrJn-s99RDXLmV9Isi93dWjGxNCuA00W1XQPOsSEKPX4r29gRckxJAHvVnCw-M-GJHQrjAbCl2Vo0cPm1l2uK_KXMs03S8sUH_xzOIay5p0r7cgSt-fRNH1sGM5cn0Lx8j0_8f_oBuR_vNg
link.rule.ids 230,315,786,790,891,4521,24144,27955,27956,45618,45712
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4BlYAL6gNoeLSp1EMlFNjEr_jYoqItsJxA4mbZXlsEqVnELld-Ox7H2Xap6IGrH5H9TTz-rPnGBvhKPQ8HLi8Lbse8oMyQQleEFN7o0klraxEThUcXfHhFT6_Z9RIc97kwKKtMvr_z6dFbp5KjhObRXdNgjq9ECX04b5DA-QlZhjfIBlDXdfj4R-chSd1xYFkW2DxlznQir1ttG9R3icMo8SIv7U7_ss_nIsq_dqWTt7CR6GT-vRvxO1hy7XtYHaWA-Qf49qOZ_EYFzv00b9rcoqwlerh8FhHPU4BmuglXJz8vj4dFehyhsLQms0I7PWDGiFpz68tqrJkVwg6oIaYaWGG1LKXRwYcERjGofKAd3nIjHYY9neaGbMFKO2ndR8hL6pAoak8Jp75iWvhABMY0sDPinPQZHPSgqLvuDgzVi8NuFUKoEEIsCxBmwHrc1IIlVXDS_-2314Os0jqaqhJf1ipZIFkZfJlXhxWAYQ3duslDbBNmKClnGWx3NpkPs5JVmIqQGYgFa80b4O3aizVtcxNv2WZ1_PDOK6fzGdaGl6Nzdf7r4mwX1rGmU8Hswcrs_sHtBy4zM5_iv_oE18PwCw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biomarkers+in+connective+tissue+diseases&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=Jog%2C+Neelakshi+R.&rft.au=James%2C+Judith+A.&rft.date=2017-12-01&rft.pub=Elsevier+Inc&rft.issn=0091-6749&rft.eissn=1097-6825&rft.volume=140&rft.issue=6&rft.spage=1473&rft.epage=1483&rft_id=info:doi/10.1016%2Fj.jaci.2017.10.003&rft.externalDocID=S0091674917316433
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0091-6749&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0091-6749&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0091-6749&client=summon