Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases - Atkinson, Jennifer M.; Falconer, Robert A.; Edwards, Dylan R.; Pennington, Caroline J.; Siller, Catherine S.; Shnyder, Steven D.; Bibby, Michael C.; Patterson, Laurence H.; Loadman, Paul M.; Gill, Jason H. (Cancer research (Chicago, Ill.), 2010)
Keywords: Angiogenesis Inhibitors - pharmacokinetics; Angiogenesis Inhibitors - pharmacology; Animals; Antineoplastic agents; Biological and medical sciences; Breast Neoplasms - blood supply; Breast Neoplasms - drug therapy; Breast Neoplasms - enzymology; Colchicine - analogs & derivatives; Colchicine - pharmacokinetics; Colchicine - pharmacology; Doxorubicin - pharmacology; Female; Fibrosarcoma - blood supply; Fibrosarcoma - drug therapy; Fibrosarcoma - enzymology; Humans; Matrix Metalloproteinases - metabolism; Matrix Metalloproteinases, Membrane-Associated - metabolism; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - enzymology; Neovascularization, Pathologic - pathology; Oligopeptides - pharmacokinetics; Oligopeptides - pharmacology; Pharmacology. Drug treatments; Thiourea - analogs & derivatives; Thiourea - pharmacokinetics; Thiourea - pharmacology; Tissue Distribution; Tumors; Xenograft Model Antitumor Assays; Peptidases; Enzyme; Targeted therapy; Blood vessel; Development; Hydrolases; Metalloendopeptidases; Circulatory system; Malignant tumor; Cancer