Expression of Follistatin-Related Genes Is Altered in Heart Failure

• Published in: Endocrinology (Philadelphia) Vol. 149; no. 11; pp. 5822 - 5827
• Main Authors: Lara-Pezzi, Enrique, Felkin, Leanne E., Birks, Emma J., Sarathchandra, Padmini, Panse, Kalyani D., George, Robert, Hall, Jennifer L., Yacoub, Magdi H., Rosenthal, Nadia, Barton, Paul J. R.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.11.2008; Endocrine Society
• Subjects: Animals; Biological activity; Biological and medical sciences; Calcium (extracellular); Calcium signalling; Cardiac muscle; Cardiology. Vascular system; Cell proliferation; Cell signaling; Cohort Studies; Congestive heart failure; Data recovery; Endothelial cells; Endothelium; Extracellular matrix; Failure; Follistatin; Follistatin-Related Proteins - genetics; Follistatin-Related Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Heart; Heart diseases; Heart failure; Heart Failure - genetics; Heart Failure - metabolism; Heart Failure - pathology; Heart Failure - surgery; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart-Assist Devices; Humans; Immunohistochemistry; Medical sciences; Muscles; Myocardium; Myocardium - metabolism; Myocardium - pathology; Myocytes; Oligonucleotide Array Sequence Analysis; Pathogenesis; Rats; Severity of Illness Index; Skeletal muscle; Smooth muscle; Therapeutic targets; Tissue Distribution; Vascularization; Ventricular assist devices; Ventricular Pressure; Ventricular Remodeling - genetics; Vertebrates: endocrinology; Wound healing; Heart failure; Cardiovascular disease; Follistatin; Gene; Heart disease

Follistatins play roles in diverse biological processes including cell proliferation, wound healing, inflammation, and skeletal muscle growth, yet their role in the heart is currently unknown. We have investigated the myocardial expression profile and cellular distribution of follistatin (FST) and t...