Systemic administration of recombinant transforming growth factor beta 2 (rTGF-β2) stimulates parameters of cancellous bone formation in juvenile and adult rats

• Published in: Bone (New York, N.Y.) Vol. 15; no. 3; pp. 355 - 359
• Main Authors: Rosen, D., Miller, S.C., Deleon, E., Thompson, A.Y., Bentz, H., Mathews, M., Adams, S.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1994; Elsevier Science
• Subjects: Aging - physiology; Animals; Biological and medical sciences; Bone Development - drug effects; Bone formation; Femur - drug effects; Femur - growth & development; Fundamental and applied biological sciences. Psychology; Growth factor; Lumbar Vertebrae - drug effects; Lumbar Vertebrae - growth & development; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins - pharmacology; Skeleton and joints; TGF-β2; Transforming Growth Factor beta - pharmacology; Vertebrates: osteoarticular system, musculoskeletal system; TGF-β2; Bone formation; Growth factor; Rat; Transforming growth factor β; Cytokine; Rodentia; Systemic route; Biological activity; Young animal; Osteoarticular system; In vivo; Vertebrata; Mammalia; Polypeptide; Adult animal; Spongious bone; Osteogenesis

Transforming growth factor β is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-β to stimulate osteogenic parameters in vitro and osteogenesis adjacent to injection sites in vivo is well established. The purpose of this study was to determine if systemic admin...