Systemic administration of recombinant transforming growth factor beta 2 (rTGF-β2) stimulates parameters of cancellous bone formation in juvenile and adult rats
Transforming growth factor β is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-β to stimulate osteogenic parameters in vitro and osteogenesis adjacent to injection sites in vivo is well established. The purpose of this study was to determine if systemic admin...
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Published in | Bone (New York, N.Y.) Vol. 15; no. 3; pp. 355 - 359 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.1994
Elsevier Science |
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Abstract | Transforming growth factor β is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-β to stimulate osteogenic parameters in vitro and osteogenesis adjacent to injection sites in vivo is well established. The purpose of this study was to determine if systemic administration of recombinant TGF-β2 (rTGF-β2) could stimulate bone formation in rats of different ages. Juvenile (25-day-old) and adult (160-day-old) rats were treated daily for 5 days and 14 days, respectively, with rTGF-β2 given by subcutaneous injection. Bone formation was measured in cancellous bone of the lumbar vertebrae in juvenile rats and the femoral epiphysis in adult rats. Endochondral bone growth rates were measured in the distal femurs from both juvenile and adult rats using histomorphometric methods. Systemic administration of rTGF-β2 resulted in substantial increases in bone formation rates (both surface and volume referent) in both juvenile and adult rats. In the juvenile rats, rTGF-β2 increased the percent double labeled surface and the mineral appositional rate. In the adult rats, TGF-β2 treatment increased the double labeled surface and also endochondral (longitudinal) growth parameters without changing the number of osteoclasts or the number of osteoclast nuclei per cell. These results demonstrate that short-term systemic administration of rTGF-β2 substantially increases cancellous bone formation rate in rats. |
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AbstractList | Transforming growth factor beta is a multifunctional protein with known actions on bone and bone cells. The ability of TGF- beta to stimulate osteogenic parameters in vitro and osteogenesis adjacent to injection sites in vivo is well established. The purpose of this study was to determine if systemic administration of recombinant TGF- beta 2 (rTGF- beta 2) could stimulate bone formation in rats of different ages. Juvenile (25-day-old) and adult (160-day-old) rats were treated daily for 5 days and 14 days, respectively, with rTGF- beta 2 given by subcutaneous injection. Bone formation was measured in cancellous bone of the lumbar vertebrae in juvenile rats and the femoral epiphysis in adult rats. Endochondral bone growth rates were measured in the distal femurs from both juvenile and adult rats using histomorphometric methods. Systemic administration of rTGF- beta 2 resulted in substantial increases in bone formation rates (both surface and volume referent) in both juvenile and adult rats. In the juvenile rats, rTGF- beta 2 increased the percent double labeled surface and the mineral appositional rate. In the adult rats, TGF- beta 2 treatment increased the double labeled surface and also endochondral (longitudinal) growth parameters without changing the number of osteoclasts or the number of osteoclast nuclei per cell. These results demonstrate that short-term systemic administration of rTGF- beta 2 substantially increases cancellous bone formation rate in rats. Transforming growth factor β is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-β to stimulate osteogenic parameters in vitro and osteogenesis adjacent to injection sites in vivo is well established. The purpose of this study was to determine if systemic administration of recombinant TGF-β2 (rTGF-β2) could stimulate bone formation in rats of different ages. Juvenile (25-day-old) and adult (160-day-old) rats were treated daily for 5 days and 14 days, respectively, with rTGF-β2 given by subcutaneous injection. Bone formation was measured in cancellous bone of the lumbar vertebrae in juvenile rats and the femoral epiphysis in adult rats. Endochondral bone growth rates were measured in the distal femurs from both juvenile and adult rats using histomorphometric methods. Systemic administration of rTGF-β2 resulted in substantial increases in bone formation rates (both surface and volume referent) in both juvenile and adult rats. In the juvenile rats, rTGF-β2 increased the percent double labeled surface and the mineral appositional rate. In the adult rats, TGF-β2 treatment increased the double labeled surface and also endochondral (longitudinal) growth parameters without changing the number of osteoclasts or the number of osteoclast nuclei per cell. These results demonstrate that short-term systemic administration of rTGF-β2 substantially increases cancellous bone formation rate in rats. |
Author | Miller, S.C. Deleon, E. Thompson, A.Y. Mathews, M. Adams, S. Rosen, D. Bentz, H. |
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Cites_doi | 10.1179/his.1991.14.2.85 10.1016/S0021-9258(17)38436-3 10.1016/S0030-5898(20)31576-5 10.1016/0169-6009(92)90844-4 10.1002/jbmr.5650060210 10.1002/jbmr.5650061117 10.1002/jbmr.5650050805 10.1002/jbmr.5650051013 10.1083/jcb.110.6.2195 10.1016/8756-3282(89)90065-3 10.1016/S0021-9258(18)61587-X 10.1002/jbmr.5650050703 10.1002/jbmr.5650051110 10.1016/0012-1606(88)90438-1 10.1007/BF02546241 10.1016/0076-6879(91)98032-2 10.1001/jama.262.7.938 10.1210/endo-126-6-3069 10.1016/8756-3282(90)90083-B 10.1210/endo-124-6-2991 10.1002/jbmr.5650020617 10.1002/jbmr.5650060910 10.1210/endo-119-5-2306 10.1210/endo-126-1-421 |
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Keywords | TGF-β2 Bone formation Growth factor Rat Transforming growth factor β Cytokine Rodentia Systemic route Biological activity Young animal Osteoarticular system In vivo Vertebrata Mammalia Polypeptide Adult animal Spongious bone Osteogenesis |
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References | DeLeon, Armstrong (BIB6) 1991; 14 Marcelli, Yates, Mundy (BIB16) 1990; 5 Ksander, Chu, McMullin, Ogawa, Pratt, Rosenblatt, McPherson (BIB13) 1990; Vol. 593 Sporn, Roberts (BIB29) 1989; 262 Hattersley, Chambers (BIB8) 1991; 6 Oreffo, Bonewald, Kukita, Garrett, Seyedin, Rosen, Mundy (BIB21) 1990; 126 Sandberg, Autio-Harmainen, Vuorio (BIB27) 1988; 130 Lomri, Marie (BIB14) 1990; 5 Tashjian, Voelkel, Lazzaro, Singer, Roberts, Derynck, Winkler, Levine (BIB30) 1985; 82 Mackie, Trechsel (BIB15) 1990; 11 Seyedin, Thompson, Bentz, Rosen, McPherson, Conti, Siegel, Galluppi, Piez (BIB28) 1986; 261 Centrella, McCarthy, Canalis (BIB4) 1987; 262 Beck, Deguzman, Lee, Xu, McFatridge, Gillett, Amento (BIB2) 1991; 6 Pfeilschifter, Mundy (BIB23) 1987; 84 Centrella, Massague, Canalis (BIB3) 1986; 119 Chenu, Kurihara, Mundy, Roodman (BIB5) 1990; 5 Frost (BIB7) 1983 Hughs, Aubin, Heerche (BIB10) 1992; 19 Beck, Ammann, Aufdemorte, Deguzman, Xu, Lee, McFatridge, Chen (BIB1) 1991; 6 Miller, Omura, Miller (BIB18) 1989; 10 Noda, Camilliere (BIB19) 1989; 124 Miller, Jee (BIB17) 1975; 18 Roberts, Sporn (BIB25) 1990 Joyce, Roberts, Sporn, Bolander (BIB11) 1990; 110 Joyce, Jinguski, Bolander (BIB12) 1990; 21 Pfeilschifter, Wolf, Nautmann, Minne, Mundy, Ziegler (BIB24) 1990; 5 Parfitt, Drezner, Glorieux, Kanis, Malluche, Meunier, Ott, Recker (BIB22) 1987; 2 Hock, Canalis, Centrella (BIB9) 1990; 126 Ogawa, Seyedin (BIB20) 1991; 198 Rosen (BIB26) 1994; Vol. 8 Beck (10.1016/8756-3282(94)90300-X_BIB1) 1991; 6 Centrella (10.1016/8756-3282(94)90300-X_BIB4) 1987; 262 Ogawa (10.1016/8756-3282(94)90300-X_BIB20) 1991; 198 Sandberg (10.1016/8756-3282(94)90300-X_BIB27) 1988; 130 Miller (10.1016/8756-3282(94)90300-X_BIB17) 1975; 18 Noda (10.1016/8756-3282(94)90300-X_BIB19) 1989; 124 Miller (10.1016/8756-3282(94)90300-X_BIB18) 1989; 10 Chenu (10.1016/8756-3282(94)90300-X_BIB5) 1990; 5 Lomri (10.1016/8756-3282(94)90300-X_BIB14) 1990; 5 Sporn (10.1016/8756-3282(94)90300-X_BIB29) 1989; 262 DeLeon (10.1016/8756-3282(94)90300-X_BIB6) 1991; 14 Oreffo (10.1016/8756-3282(94)90300-X_BIB21) 1990; 126 Mackie (10.1016/8756-3282(94)90300-X_BIB15) 1990; 11 Hughs (10.1016/8756-3282(94)90300-X_BIB10) 1992; 19 Roberts (10.1016/8756-3282(94)90300-X_BIB25) 1990 Joyce (10.1016/8756-3282(94)90300-X_BIB12) 1990; 21 Seyedin (10.1016/8756-3282(94)90300-X_BIB28) 1986; 261 Tashjian (10.1016/8756-3282(94)90300-X_BIB30) 1985; 82 Pfeilschifter (10.1016/8756-3282(94)90300-X_BIB24) 1990; 5 Rosen (10.1016/8756-3282(94)90300-X_BIB26) 1994; Vol. 8 Ksander (10.1016/8756-3282(94)90300-X_BIB13) 1990; Vol. 593 Frost (10.1016/8756-3282(94)90300-X_BIB7) 1983 Parfitt (10.1016/8756-3282(94)90300-X_BIB22) 1987; 2 Centrella (10.1016/8756-3282(94)90300-X_BIB3) 1986; 119 Marcelli (10.1016/8756-3282(94)90300-X_BIB16) 1990; 5 Beck (10.1016/8756-3282(94)90300-X_BIB2) 1991; 6 Joyce (10.1016/8756-3282(94)90300-X_BIB11) 1990; 110 Hattersley (10.1016/8756-3282(94)90300-X_BIB8) 1991; 6 Hock (10.1016/8756-3282(94)90300-X_BIB9) 1990; 126 Pfeilschifter (10.1016/8756-3282(94)90300-X_BIB23) 1987; 84 |
References_xml | – start-page: 133 year: 1983 end-page: 142 ident: BIB7 article-title: Bone histomorphometry: Analysis of the labeling “escape error” publication-title: Bone histomorphometry: techniques and interpretation contributor: fullname: Frost – volume: 198 start-page: 317 year: 1991 end-page: 327 ident: BIB20 article-title: Purification of transforming growth factors β1 and β2 from bovine bone and cell culture assays publication-title: Meth. Enzymol. contributor: fullname: Seyedin – volume: 130 start-page: 324 year: 1988 end-page: 334 ident: BIB27 article-title: Localization of the expression of types I, III and IV collagen, TGF-β1 and c-fos genes in developing human calvarial bones publication-title: Devel. Biol. contributor: fullname: Vuorio – volume: 21 start-page: 199 year: 1990 end-page: 209 ident: BIB12 article-title: Transforming growth factor-β in the regulation of fracture repair publication-title: Orthop. Clin. N. Am. contributor: fullname: Bolander – volume: 6 start-page: 1257 year: 1991 end-page: 1265 ident: BIB2 article-title: TGF-β1 induces bone closure of skull defects publication-title: J. Bone Miner. Res. contributor: fullname: Amento – volume: 110 start-page: 2195 year: 1990 end-page: 2207 ident: BIB11 article-title: Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur publication-title: J. Cell Biol. contributor: fullname: Bolander – volume: 6 start-page: 961 year: 1991 end-page: 968 ident: BIB1 article-title: In vivo induction of bone by recombinant human transforming growth factor β publication-title: J. Bone Miner. Res. contributor: fullname: Chen – volume: 19 start-page: 63 year: 1992 end-page: 74 ident: BIB10 article-title: Differential chemotactic responses of different populations of fetal rat calvarial cells to PDGF and TGF-β publication-title: Bone Miner. contributor: fullname: Heerche – volume: 126 start-page: 3069 year: 1990 end-page: 3075 ident: BIB21 article-title: Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-β on isolated osteoclasts publication-title: Endocrinology contributor: fullname: Mundy – volume: 2 start-page: 595 year: 1987 end-page: 609 ident: BIB22 article-title: Bone histomorphometry: Standardization of nomenclature, symbols, and units publication-title: J. Bone Miner. Res. contributor: fullname: Recker – volume: 262 start-page: 2869 year: 1987 end-page: 2874 ident: BIB4 article-title: Transforming growth factor-β is a bifunctional regulator of replication and collagen synthesis in osteoblastenriched cell cultures from fetal rat bone publication-title: J. Biol. Chem. contributor: fullname: Canalis – volume: 82 start-page: 4535 year: 1985 end-page: 4538 ident: BIB30 article-title: Alpha and β human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Levine – volume: 84 start-page: 2024 year: 1987 end-page: 2028 ident: BIB23 article-title: Modulation of type β transforming growth factor activity in bone cultures by osteotropic hormones publication-title: Proc. Natl. Acad. Sci. (USA) contributor: fullname: Mundy – volume: 5 start-page: 1149 year: 1990 end-page: 1155 ident: BIB14 article-title: Bone cell responsiveness to TGF-β, parathyroid hormone, and prostaglandin E publication-title: J. Bone Min. Res. contributor: fullname: Marie – volume: 5 start-page: 677 year: 1990 end-page: 681 ident: BIB5 article-title: Prostaglandin E2 inhibits formation of osteoclastlike cells in long-term human marrow cultures but is not a mediator of the inhibitory effects of transforming growth factor β publication-title: J. Bone Min. Res. contributor: fullname: Roodman – volume: 14 start-page: 85 year: 1991 end-page: 88 ident: BIB6 article-title: Modified Giemsa stain for polymethyl methacrylate embedded undecalcified bone and bone marrow specimens publication-title: J. Histotechnol. contributor: fullname: Armstrong – volume: 261 start-page: 5693 year: 1986 end-page: 5695 ident: BIB28 article-title: Cartilage-inducing factor-A. Apparent identity to transforming growth factor β publication-title: J. Biol. Chem. contributor: fullname: Piez – volume: 5 start-page: 825 year: 1990 end-page: 830 ident: BIB24 article-title: Chemotactic response of osteoblast-like cells to TGF-β publication-title: J. Bone Min. Res. contributor: fullname: Ziegler – volume: 126 start-page: 421 year: 1990 end-page: 426 ident: BIB9 article-title: Transforming growth factor-β stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae publication-title: Endocrinology contributor: fullname: Centrella – volume: 5 start-page: 1087 year: 1990 end-page: 1096 ident: BIB16 article-title: In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice publication-title: J. Bone Miner. Res. contributor: fullname: Mundy – volume: 10 start-page: 279 year: 1989 end-page: 285 ident: BIB18 article-title: Increased cancellous bone remodeling during lactation in beagles publication-title: Bone contributor: fullname: Miller – volume: 262 start-page: 938 year: 1989 end-page: 941 ident: BIB29 article-title: Transforming growth factor-β. Multiple actions and potential clinical applications publication-title: JAMA contributor: fullname: Roberts – volume: Vol. 8 year: 1994 ident: BIB26 article-title: Transforming growth factor-βs: biological activities related to bone metabolism publication-title: Bone and mineral research contributor: fullname: Rosen – volume: 119 start-page: 2306 year: 1986 end-page: 2312 ident: BIB3 article-title: Human platelet-derived transforming growth factor-β stimulates parameters of bone growth in fetal rat calvariae publication-title: Endocrinology contributor: fullname: Canalis – volume: 6 start-page: 165 year: 1991 end-page: 172 ident: BIB8 article-title: Effects of transforming growth factor β publication-title: J. Bone Miner. Res. contributor: fullname: Chambers – volume: 18 start-page: 215 year: 1975 end-page: 231 ident: BIB17 article-title: Ethane-1-hydroxy-1,1-diphosphonate (EHDP) effects on growth and modeling of the rat tibia publication-title: Calcif. Tissue Res. contributor: fullname: Jee – volume: 124 start-page: 2991 year: 1989 end-page: 2994 ident: BIB19 article-title: In vivo stimulation of bone formation by transforming growth factor-β publication-title: Endocrinology contributor: fullname: Camilliere – start-page: 419 year: 1990 end-page: 472 ident: BIB25 article-title: The transforming growth factor-βs publication-title: The Handbook of experimental pharmacology contributor: fullname: Sporn – volume: Vol. 593 start-page: 135 year: 1990 end-page: 147 ident: BIB13 article-title: Transforming growth factors-β1 and β2 enhance connective tissue formation in animal models of dermal wound healing by secondary intent publication-title: Transforming growth factor-βs chemistry, biology, and therapeutics contributor: fullname: McPherson – volume: 11 start-page: 295 year: 1990 end-page: 300 ident: BIB15 article-title: Stimulation of bone formation in vivo by transforming growth factor-β: Remodeling of woven bone and lack of inhibition by indomethacin publication-title: Bone contributor: fullname: Trechsel – volume: 82 start-page: 4535 year: 1985 ident: 10.1016/8756-3282(94)90300-X_BIB30 article-title: Alpha and β human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria contributor: fullname: Tashjian – volume: 14 start-page: 85 year: 1991 ident: 10.1016/8756-3282(94)90300-X_BIB6 article-title: Modified Giemsa stain for polymethyl methacrylate embedded undecalcified bone and bone marrow specimens publication-title: J. Histotechnol. doi: 10.1179/his.1991.14.2.85 contributor: fullname: DeLeon – volume: 261 start-page: 5693 year: 1986 ident: 10.1016/8756-3282(94)90300-X_BIB28 article-title: Cartilage-inducing factor-A. Apparent identity to transforming growth factor β publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)38436-3 contributor: fullname: Seyedin – volume: 21 start-page: 199 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB12 article-title: Transforming growth factor-β in the regulation of fracture repair publication-title: Orthop. Clin. N. Am. doi: 10.1016/S0030-5898(20)31576-5 contributor: fullname: Joyce – volume: 84 start-page: 2024 year: 1987 ident: 10.1016/8756-3282(94)90300-X_BIB23 article-title: Modulation of type β transforming growth factor activity in bone cultures by osteotropic hormones contributor: fullname: Pfeilschifter – volume: 19 start-page: 63 year: 1992 ident: 10.1016/8756-3282(94)90300-X_BIB10 article-title: Differential chemotactic responses of different populations of fetal rat calvarial cells to PDGF and TGF-β publication-title: Bone Miner. doi: 10.1016/0169-6009(92)90844-4 contributor: fullname: Hughs – volume: 6 start-page: 165 year: 1991 ident: 10.1016/8756-3282(94)90300-X_BIB8 article-title: Effects of transforming growth factor β1 on the regulation of osteoclastic development and function publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650060210 contributor: fullname: Hattersley – volume: 6 start-page: 1257 year: 1991 ident: 10.1016/8756-3282(94)90300-X_BIB2 article-title: TGF-β1 induces bone closure of skull defects publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650061117 contributor: fullname: Beck – volume: 5 start-page: 825 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB24 article-title: Chemotactic response of osteoblast-like cells to TGF-β publication-title: J. Bone Min. Res. doi: 10.1002/jbmr.5650050805 contributor: fullname: Pfeilschifter – volume: 5 start-page: 1087 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB16 article-title: In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650051013 contributor: fullname: Marcelli – volume: 110 start-page: 2195 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB11 article-title: Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur publication-title: J. Cell Biol. doi: 10.1083/jcb.110.6.2195 contributor: fullname: Joyce – volume: 10 start-page: 279 year: 1989 ident: 10.1016/8756-3282(94)90300-X_BIB18 article-title: Increased cancellous bone remodeling during lactation in beagles publication-title: Bone doi: 10.1016/8756-3282(89)90065-3 contributor: fullname: Miller – volume: 262 start-page: 2869 year: 1987 ident: 10.1016/8756-3282(94)90300-X_BIB4 article-title: Transforming growth factor-β is a bifunctional regulator of replication and collagen synthesis in osteoblastenriched cell cultures from fetal rat bone publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)61587-X contributor: fullname: Centrella – volume: Vol. 8 year: 1994 ident: 10.1016/8756-3282(94)90300-X_BIB26 article-title: Transforming growth factor-βs: biological activities related to bone metabolism contributor: fullname: Rosen – volume: 5 start-page: 677 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB5 article-title: Prostaglandin E2 inhibits formation of osteoclastlike cells in long-term human marrow cultures but is not a mediator of the inhibitory effects of transforming growth factor β publication-title: J. Bone Min. Res. doi: 10.1002/jbmr.5650050703 contributor: fullname: Chenu – start-page: 133 year: 1983 ident: 10.1016/8756-3282(94)90300-X_BIB7 article-title: Bone histomorphometry: Analysis of the labeling “escape error” contributor: fullname: Frost – volume: 5 start-page: 1149 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB14 article-title: Bone cell responsiveness to TGF-β, parathyroid hormone, and prostaglandin E2 in normal and osteoporotic women publication-title: J. Bone Min. Res. doi: 10.1002/jbmr.5650051110 contributor: fullname: Lomri – volume: 130 start-page: 324 year: 1988 ident: 10.1016/8756-3282(94)90300-X_BIB27 article-title: Localization of the expression of types I, III and IV collagen, TGF-β1 and c-fos genes in developing human calvarial bones publication-title: Devel. Biol. doi: 10.1016/0012-1606(88)90438-1 contributor: fullname: Sandberg – volume: 18 start-page: 215 year: 1975 ident: 10.1016/8756-3282(94)90300-X_BIB17 article-title: Ethane-1-hydroxy-1,1-diphosphonate (EHDP) effects on growth and modeling of the rat tibia publication-title: Calcif. Tissue Res. doi: 10.1007/BF02546241 contributor: fullname: Miller – volume: 198 start-page: 317 year: 1991 ident: 10.1016/8756-3282(94)90300-X_BIB20 article-title: Purification of transforming growth factors β1 and β2 from bovine bone and cell culture assays publication-title: Meth. Enzymol. doi: 10.1016/0076-6879(91)98032-2 contributor: fullname: Ogawa – volume: 262 start-page: 938 year: 1989 ident: 10.1016/8756-3282(94)90300-X_BIB29 article-title: Transforming growth factor-β. Multiple actions and potential clinical applications publication-title: JAMA doi: 10.1001/jama.262.7.938 contributor: fullname: Sporn – volume: 126 start-page: 3069 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB21 article-title: Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-β on isolated osteoclasts publication-title: Endocrinology doi: 10.1210/endo-126-6-3069 contributor: fullname: Oreffo – volume: 11 start-page: 295 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB15 article-title: Stimulation of bone formation in vivo by transforming growth factor-β: Remodeling of woven bone and lack of inhibition by indomethacin publication-title: Bone doi: 10.1016/8756-3282(90)90083-B contributor: fullname: Mackie – volume: 124 start-page: 2991 year: 1989 ident: 10.1016/8756-3282(94)90300-X_BIB19 article-title: In vivo stimulation of bone formation by transforming growth factor-β publication-title: Endocrinology doi: 10.1210/endo-124-6-2991 contributor: fullname: Noda – volume: 2 start-page: 595 year: 1987 ident: 10.1016/8756-3282(94)90300-X_BIB22 article-title: Bone histomorphometry: Standardization of nomenclature, symbols, and units publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650020617 contributor: fullname: Parfitt – volume: Vol. 593 start-page: 135 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB13 article-title: Transforming growth factors-β1 and β2 enhance connective tissue formation in animal models of dermal wound healing by secondary intent contributor: fullname: Ksander – volume: 6 start-page: 961 year: 1991 ident: 10.1016/8756-3282(94)90300-X_BIB1 article-title: In vivo induction of bone by recombinant human transforming growth factor β1 publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650060910 contributor: fullname: Beck – volume: 119 start-page: 2306 year: 1986 ident: 10.1016/8756-3282(94)90300-X_BIB3 article-title: Human platelet-derived transforming growth factor-β stimulates parameters of bone growth in fetal rat calvariae publication-title: Endocrinology doi: 10.1210/endo-119-5-2306 contributor: fullname: Centrella – volume: 126 start-page: 421 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB9 article-title: Transforming growth factor-β stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae publication-title: Endocrinology doi: 10.1210/endo-126-1-421 contributor: fullname: Hock – start-page: 419 year: 1990 ident: 10.1016/8756-3282(94)90300-X_BIB25 article-title: The transforming growth factor-βs contributor: fullname: Roberts |
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Snippet | Transforming growth factor β is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-β to stimulate osteogenic parameters in... Transforming growth factor beta is a multifunctional protein with known actions on bone and bone cells. The ability of TGF-beta to stimulate osteogenic... Transforming growth factor beta is a multifunctional protein with known actions on bone and bone cells. The ability of TGF- beta to stimulate osteogenic... |
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SubjectTerms | Aging - physiology Animals Biological and medical sciences Bone Development - drug effects Bone formation Femur - drug effects Femur - growth & development Fundamental and applied biological sciences. Psychology Growth factor Lumbar Vertebrae - drug effects Lumbar Vertebrae - growth & development Male Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Skeleton and joints TGF-β2 Transforming Growth Factor beta - pharmacology Vertebrates: osteoarticular system, musculoskeletal system |
Title | Systemic administration of recombinant transforming growth factor beta 2 (rTGF-β2) stimulates parameters of cancellous bone formation in juvenile and adult rats |
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