Comprehensive Molecular Detection of Tick-Borne Phleboviruses Leads to the Retrospective Identification of Taxonomically Unassigned Bunyaviruses and the Discovery of a Novel Member of the Genus Phlebovirus

• Published in: Journal of virology Vol. 89; no. 1; pp. 594 - 604
• Main Authors: Matsuno, Keita, Weisend, Carla, Kajihara, Masahiro, Matysiak, Colette, Williamson, Brandi N., Simuunza, Martin, Mweene, Aaron S., Takada, Ayato, Tesh, Robert B., Ebihara, Hideki
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2015
• Subjects: Animals; Cluster Analysis; DNA Primers - genetics; Genetic Diversity and Evolution; Genome, Viral; Ixodidae; Molecular Sequence Data; Orthobunyavirus - classification; Orthobunyavirus - genetics; Orthobunyavirus - isolation & purification; Phlebovirus; Phlebovirus - classification; Phlebovirus - genetics; Phlebovirus - isolation & purification; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA, Viral - genetics; Sequence Analysis, DNA; Ticks - virology; Virology - methods

Until the recent emergence of two human-pathogenic tick-borne phleboviruses (TBPVs) (severe fever with thrombocytopenia syndrome virus [SFTSV] and Heartland virus), TBPVs have been neglected as causative agents of human disease. In particular, no studies have addressed the global distribution of TBP...