Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

• Published in: Journal of pharmacokinetics and pharmacodynamics Vol. 47; no. 5; pp. 485 - 492
• Main Authors: Chasseloup, Estelle, Yngman, Gunnar, Karlsson, Mats O.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Correlation; Covariates; Full fixed effects modelling; Original Paper; Pharmacology/Toxicology; Pharmacy; Prior; Prior-adjusted covariate selection; Stepwise covariate modelling; Veterinary Medicine/Veterinary Science; Stepwise covariate modelling; Prior-adjusted covariate selection; Correlation; Full fixed effects modelling; Covariates; Prior

The inclusion of covariates in population models during drug development is a key step to understanding drug variability and support dosage regimen proposal, but high correlation among covariates often complicates the identification of the true covariate. We compared three covariate selection method...