Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity

• Published in: Infection and immunity Vol. 84; no. 8; pp. 2175 - 2184
• Main Authors: Hill, Danika L, Wilson, Danny W, Sampaio, Natalia G, Eriksson, Emily M, Ryg-Cornejo, Victoria, Harrison, G L Abby, Uboldi, Alessandro D, Robinson, Leanne J, Beeson, James G, Siba, Peter, Cowman, Alan F, Hansen, Diana S, Mueller, Ivo, Schofield, Louis
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.08.2016
• Subjects: Adolescent; Antibodies, Protozoan - blood; Antibodies, Protozoan - immunology; Antigens, Protozoan - immunology; Child; Child, Preschool; Humans; Malaria, Falciparum - blood; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Merozoites - immunology; Microbial Immunity and Vaccines; Opsonin Proteins - immunology; Patient Outcome Assessment; Phagocytosis - immunology; Plasmodium falciparum; Plasmodium falciparum - immunology

It is unclear whether naturally acquired immunity to Plasmodium falciparum results from the acquisition of antibodies to multiple, diverse antigens or to fewer, highly conserved antigens. Moreover, the specific antibody functions required for malaria immunity are unknown, and hence informative immun...