EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling - Chang, Chun-Ju; Yang, Jer-Yen; Xia, Weiya; Chen, Chun-Te; Xie, Xiaoming; Chao, Chi-Hong; Woodward, Wendy A.; Hsu, Jung-Mao; Hortobagyi, Gabriel N.; Hung, Mien-Chie (Cancer cell, 2011)
Keywords: Animals; Benzenesulfonates - pharmacology; Benzimidazoles - pharmacology; Benzimidazoles - therapeutic use; beta Catenin - metabolism; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Hypoxia - physiology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell Survival - physiology; Centrosome - pathology; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Damage - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Enhancer of Zeste Homolog 2 Protein; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Gene Expression - drug effects; Gene Expression - genetics; Gene Expression Regulation, Neoplastic - physiology; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Models, Biological; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Niacinamide - analogs & derivatives; Phenylurea Compounds; Phosphorylation - drug effects; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-raf - genetics; Proto-Oncogene Proteins c-raf - metabolism; Pyridines - pharmacology; Rad51 Recombinase - genetics; Rad51 Recombinase - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; Sorafenib; Spheroids, Cellular - drug effects; Spheroids, Cellular - pathology; Transcription Factors - genetics; Transcription Factors - metabolism; Transplantation, Heterologous - pathology; Xenograft Model Antitumor Assays