Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity

• Published in: Journal of virology Vol. 90; no. 18; pp. 8105 - 8114
• Main Authors: Xu, Guanlong, Zhang, Xuxiao, Gao, Weihua, Wang, Chenxi, Wang, Jinliang, Sun, Honglei, Sun, Yipeng, Guo, Lu, Zhang, Rui, Chang, Kin-Chow, Liu, Jinhua, Pu, Juan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.09.2016
• Subjects: Animals; Cell Line; Disease Models, Animal; Epithelial Cells - virology; Humans; Influenza A virus; Influenza A Virus, H9N2 Subtype - pathogenicity; Influenza A Virus, H9N2 Subtype - physiology; Mice; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation, Missense; Orthomyxoviridae; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - virology; Pathogenesis and Immunity; RNA Replicase - genetics; RNA Replicase - metabolism; Survival Analysis; Viral Proteins - genetics; Viral Proteins - metabolism; Viral Tropism; Virus Replication

Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in China as with seasonal human H1N1 viruses. The sa...