Technology Insight: laser-scanning confocal microscopy and endocytoscopy for cellular observation of the gastrointestinal tract
Recent advances in endoscopic imaging technology have enabled the visualization of early-stage cancer and its precursors in the gastrointestinal tract. Chromoendoscopy, magnifying endoscopy, endoscopic optical coherent tomography, spectroscopy, and various combinations of these technologies, are all...
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| Published in | Nature clinical practice. Gastroenterology & hepatology Vol. 2; no. 1; pp. 31 - 37 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Nature Publishing Group
01.01.2005
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Recent advances in endoscopic imaging technology have enabled the visualization of early-stage cancer and its precursors in the gastrointestinal tract. Chromoendoscopy, magnifying endoscopy, endoscopic optical coherent tomography, spectroscopy, and various combinations of these technologies, are all important for the recognition of small and unclear lesions. To observe cancer cells in vivo, two types of ultra-high magnifying endoscope--'laser-scanning confocal endoscopy series' and 'contact endoscopy series'--that have a maximum of more than 1,000x magnifying power have been developed. These endoscopes can generate high-quality images of both living cancer cells and normal cells in the gastrointestinal tract, with a quality comparable to that possible with conventional cytology. These novel imaging technologies may make in vivo histological diagnosis by virtual histology possible. |
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| AbstractList | Recent advances in endoscopic imaging technology have enabled the visualization of early-stage cancer and its precursors in the gastrointestinal tract. Chromoendoscopy, magnifying endoscopy, endoscopic optical coherent tomography, spectroscopy, and various combinations of these technologies, are all important for the recognition of small and unclear lesions. To observe cancer cells in vivo, two types of ultra-high magnifying endoscope--'laser-scanning confocal endoscopy series' and 'contact endoscopy series'--that have a maximum of more than 1,000x magnifying power have been developed. These endoscopes can generate high-quality images of both living cancer cells and normal cells in the gastrointestinal tract, with a quality comparable to that possible with conventional cytology. These novel imaging technologies may make in vivo histological diagnosis by virtual histology possible. Recent advances in endoscopic imaging technology have enabled the visualization of early-stage cancer and its precursors in the gastrointestinal tract. Chromoendoscopy, magnifying endoscopy, endoscopic optical coherent tomography, spectroscopy, and various combinations of these technologies, are all important for the recognition of small and unclear lesions. To observe cancer cells in vivo, two types of ultra-high magnifying endoscope--'laser-scanning confocal endoscopy series' and 'contact endoscopy series'--that have a maximum of more than 1,000× magnifying power have been developed. These endoscopes can generate high-quality images of both living cancer cells and normal cells in the gastrointestinal tract, with a quality comparable to that possible with conventional cytology. These novel imaging technologies may make in vivo histological diagnosis by virtual histology possible. |
| Audience | Academic |
| Author | Inoue, Haruhiro Shiokawa, Akira Kudo, Shin-ei |
| Author_xml | – sequence: 1 givenname: Haruhiro surname: Inoue fullname: Inoue, Haruhiro organization: Digestive Disease Center Department of Pathology, Showa University Northern Yokohama Hospital – sequence: 2 givenname: Shin-ei surname: Kudo fullname: Kudo, Shin-ei organization: Digestive Disease Center Department of Pathology, Showa University Northern Yokohama Hospital – sequence: 3 givenname: Akira surname: Shiokawa fullname: Shiokawa, Akira organization: Digestive Disease Center Department of Pathology, Showa University Northern Yokohama Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16265098$$D View this record in MEDLINE/PubMed |
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| Snippet | Recent advances in endoscopic imaging technology have enabled the visualization of early-stage cancer and its precursors in the gastrointestinal tract.... |
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| SubjectTerms | Confocal microscopy Diagnosis Endoscopy, Gastrointestinal - methods Gastrointestinal cancer Gastrointestinal Neoplasms - pathology Gastrointestinal system Health aspects Humans Intestinal Mucosa - ultrastructure Microscopy, Confocal Physiological aspects |
| Title | Technology Insight: laser-scanning confocal microscopy and endocytoscopy for cellular observation of the gastrointestinal tract |
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