Cross-Reactive Immune Response of Bovine Coronavirus Spike Glycoprotein to SARS-CoV-2 Variants of Concern

• Published in: International journal of molecular sciences Vol. 25; no. 21; p. 11509
• Main Authors: Cossu, Chiara, Franceschi, Valentina, Di Lorenzo, Antonino, Bolli, Elisabetta, Minesso, Sergio, Cotti, Camilla, Conti, Laura, Donofrio, Gaetano
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Artificial chromosomes; Asymptomatic; Cattle; Coronavirus, Bovine - immunology; COVID-19 - immunology; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - immunology; Cross Reactions - immunology; Disease transmission; Female; Glycoproteins; Health aspects; Herpes viruses; Humans; Immune response; Immunity (Disease); Immunity, Humoral - immunology; Immunological research; Infections; Lymphocytes; Mice; Mice, Inbred BALB C; Middle East respiratory syndrome; Physiological aspects; Proteins; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Vectors (Biology); Viral proteins; Italy; COVID-19; immune cross-reaction; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); bovine coronavirus; bovine herpesvirus 4; spike; vaccination

The high variability observed in the clinical symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has been attributed to the presence, in a proportion of infection-naive subjects, of pre-existing cross-reactive immune responses. Here, we demonstrate that the bovine co...