Telomere biology and age-related diseases

• Published in: Clinical chemistry and laboratory medicine Vol. 56; no. 8; pp. 1210 - 1222
• Main Authors: Herrmann, Markus, Pusceddu, Irene, März, Winfried, Herrmann, Wolfgang
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 26.07.2018; Walter De Gruyter & Company
• Subjects: Age; age-related diseases; Arteriosclerosis; Atherosclerosis; Biocompatibility; biological age; Biology; Biomarkers; Biomedical materials; Bone mineral density; Breast cancer; Cancer; Cardiovascular diseases; Cell division; Chromosomes; Colon; Colon cancer; Disease; Epidemiology; Health risks; Lesions; Leukocytes; Osteoporosis; Prostate; Risk factors; senescence; Telomerase; telomere length; Telomeres; Tumors; senescence; age-related diseases; biological age; telomere length; telomeres

Telomeres are the protective end caps of chromosomes and shorten with every cell division. Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases. Epidemiologic studies show an association between leukocyte telomere length (LTL) and mortality. T...