Oral sensitization with shrimp tropomyosin induces in mice allergen-specific IgE, T cell response and systemic anaphylactic reactions

• Published in: International immunology Vol. 20; no. 8; pp. 1077 - 1086
• Main Authors: Capobianco, Francescamaria, Butteroni, Cinzia, Barletta, Bianca, Corinti, Silvia, Afferni, Claudia, Tinghino, Raffaella, Boirivant, Monica, Di Felice, Gabriella
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2008; Oxford Publishing Limited (England)
• Subjects: Administration, Oral; Allergens; Allergies; anaphylaxis; Anaphylaxis - blood; Anaphylaxis - etiology; Animals; Arthropod Proteins; Desensitization, Immunologic; Disease Models, Animal; Epitopes; Food allergies; food allergy; Food Hypersensitivity - immunology; Food Hypersensitivity - therapy; Histamine; Histamine Release - drug effects; Histamine Release - immunology; Immunoglobulin E - blood; Immunoglobulin E - immunology; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Mice; Mice, Inbred C3H; murine model; oral sensitization; Proteins - administration & dosage; Proteins - immunology; Shellfish - adverse effects; shrimp tropomyosin; Th2 Cells - cytology; Th2 Cells - immunology; Th2 Cells - metabolism; Toxins; Waterborne diseases; anaphylaxis; murine model; food allergy; oral sensitization; shrimp tropomyosin

Appropriate murine models of shrimp tropomyosin (ST) allergy would be useful in investigating the mechanisms underlying food allergy in human subjects, as well as for the pre-clinical evaluation of efficacy and safety of novel therapeutic approaches. These models should mimic immune and clinical fea...