Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women

• Published in: Endocrinology (Philadelphia) Vol. 147; no. 3; pp. 1097 - 1121
• Main Authors: Talbi, S., Hamilton, A. E., Vo, K. C., Tulac, S., Overgaard, M. T., Dosiou, C., Le Shay, N., Nezhat, C. N., Kempson, R., Lessey, B. A., Nayak, N. R., Giudice, L. C.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.03.2006; Oxford University Press
• Subjects: Abnormalities; Adult; Algorithms; Biological activity; Biological and medical sciences; Biological effects; Biopsy; Cluster Analysis; Clustering; Disorders; DNA microarrays; Down-Regulation; Endometrial Neoplasms - metabolism; Endometrium; Endometrium - metabolism; Endometrium - physiology; Evaluation; Expressed sequence tags; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Genome; Heterogeneity; Histology; Humans; Hysterectomy; Menstrual cycle; Menstrual Cycle - physiology; Menstruation; Middle Aged; Models, Biological; Molecular modelling; Multigene Family; Nucleotide sequence; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Ovulation; Phases; Phenotype; Phenotypes; Phenotypic variations; Phenotyping; Principal Component Analysis; Principal components analysis; Reverse Transcriptase Polymerase Chain Reaction; Sampling methods; Signal Transduction; Signatures; Steroids - metabolism; Therapeutic applications; Up-Regulation; Uterine Diseases - genetics; Uterine Diseases - pathology; Uterus - metabolism; Uterus - physiology; Vector quantization; Vertebrates: endocrinology; Human; Female; Uterus; Menstrual cycle; Endometrium; Female genital system

Histological evaluation of endometrium has been the gold standard for clinical diagnosis and management of women with endometrial disorders. However, several recent studies have questioned the accuracy and utility of such evaluation, mainly because of significant intra- and interobserver variations...