Administration of Protein-Conjugate Pneumococcal Vaccine to Patients Who Have Invasive Disease after Splenectomy Despite Their Having Received 23-Valent Pneumococcal Polysaccharide Vaccine
Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three–valent pneumococcal polysaccharide vaccine (PPV-23), which contains capsular polysaccharides (PSs) from 23 common serotypes of Streptococcus pneumoniae is strongly recommen...
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Published in | The Journal of infectious diseases Vol. 191; no. 7; pp. 1063 - 1067 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Chicago, IL
The University of Chicago Press
01.04.2005
University of Chicago Press Oxford University Press |
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Abstract | Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three–valent pneumococcal polysaccharide vaccine (PPV-23), which contains capsular polysaccharides (PSs) from 23 common serotypes of Streptococcus pneumoniae is strongly recommended for such patients. The capacity to respond to PPV-23 by producing immunoglobulin (Ig) G is genetically regulated. Some proportion of adults do not respond and, despite postsplenectomy administration of PPV-23, may remain susceptible to recurrent pneumococcal sepsis. Here, we describe 2 patients who had recurring pneumococcal bacteremia after undergoing splenectomy despite having received numerous doses of PPV-23. Heptavalent protein-conjugate pneumococcal vaccine (PCPV-7) was then administered, and it induced high levels of IgG to all 7 PSs; in one of the patients, functional activity against 5 of the 7 PSs was demonstrable, both in vitro and in vivo. Recurrent pneumococcal bacteremia in patients who have undergone splenectomy may indicate a genetically regulated failure to respond to PPV-23; PCPV-7 may stimulate production of IgG to PSs in such patients |
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AbstractList | Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three-valent pneumococcal polysaccharide vaccine (PPV-23), which contains capsular polysaccharides (PSs) from 23 common serotypes of Streptococcus pneumoniae, is strongly recommended for such patients. The capacity to respond to PPV-23 by producing immunoglobulin (Ig) G is genetically regulated. Some proportion of adults do not respond and, despite postsplenectomy administration of PPV-23, may remain susceptible to recurrent pneumococcal sepsis. Here, we describe 2 patients who had recurring pneumococcal bacteremia after undergoing splenectomy despite having received numerous doses of PPV-23. Heptavalent protein-conjugate pneumococcal vaccine (PCPV-7) was then administered, and it induced high levels of IgG to all 7 PSs; in one of the patients, functional activity against 5 of the 7 PSs was demonstrable, both in vitro and in vivo. Recurrent pneumococcal bacteremia in patients who have undergone splenectomy may indicate a genetically regulated failure to respond to PPV-23; PCPV-7 may stimulate production of IgG to PSs in such patients. Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three–valent pneumococcal polysaccharide vaccine (PPV-23), which contains capsular polysaccharides (PSs) from 23 common serotypes of Streptococcus pneumoniae is strongly recommended for such patients. The capacity to respond to PPV-23 by producing immunoglobulin (Ig) G is genetically regulated. Some proportion of adults do not respond and, despite postsplenectomy administration of PPV-23, may remain susceptible to recurrent pneumococcal sepsis. Here, we describe 2 patients who had recurring pneumococcal bacteremia after undergoing splenectomy despite having received numerous doses of PPV-23. Heptavalent protein-conjugate pneumococcal vaccine (PCPV-7) was then administered, and it induced high levels of IgG to all 7 PSs; in one of the patients, functional activity against 5 of the 7 PSs was demonstrable, both in vitro and in vivo. Recurrent pneumococcal bacteremia in patients who have undergone splenectomy may indicate a genetically regulated failure to respond to PPV-23; PCPV-7 may stimulate production of IgG to PSs in such patients Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three-valent pneumococcal polysaccharide vaccine (PPV-23), which contains capsular polysaccharides (PSs) from 23 common serotypes of Streptococcus pneumoniae, is strongly recommended for such patients. The capacity to respond to PPV-23 by producing immunoglobulin (Ig) G is genetically regulated. Some proportion of adults do not respond and, despite postsplenectomy administration of PPV-23, may remain susceptible to recurrent pneumococcal sepsis. Here, we describe 2 patients who had recurring pneumococcal bacteremia after undergoing splenectomy despite having received numerous doses of PPV-23. Heptavalent proteinconjugate pneumococcal vaccine (PCPV-7) was then administered, and it induced high levels of IgG to all 7 PSs; in one of the patients, functional activity against 5 of the 7 PSs was demonstrable, both in vitro and in vivo. Recurrent pneumococcal bacteremia in patients who have undergone splenectomy may indicate a genetically regulated failure to respond to PPV-23; PCPV-7 may stimulate production of IgG to PSs in such patients. |
Author | Ceasar, Heather Musher, Benjamin L. Musher, Daniel M. White, A. Clinton Romero-Steiner, Sandra Kojic, Erna M. Gathe, Joseph C. |
Author_xml | – sequence: 1 givenname: Daniel M. surname: Musher fullname: Musher, Daniel M. email: daniel.musher@med.va.gov organization: Infectious Disease Section, Michael E. DeBakey Veterans Affairs Medical Center – sequence: 2 givenname: Heather surname: Ceasar fullname: Ceasar, Heather organization: Infectious Disease Section, Michael E. DeBakey Veterans Affairs Medical Center – sequence: 3 givenname: Erna M. surname: Kojic fullname: Kojic, Erna M. organization: Medicine and – sequence: 4 givenname: Benjamin L. surname: Musher fullname: Musher, Benjamin L. organization: Medicine and – sequence: 5 givenname: Joseph C. surname: Gathe fullname: Gathe, Joseph C. organization: Medicine and – sequence: 6 givenname: Sandra surname: Romero-Steiner fullname: Romero-Steiner, Sandra organization: Centers for Disease Control and Prevention, Atlanta, Georgia – sequence: 7 givenname: A. Clinton surname: White fullname: White, A. Clinton organization: Ben Taub General Hospital, and Departments of |
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Snippet | Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three–valent pneumococcal... Patients who undergo splenectomy are at greatly increased risk for overwhelming pneumococcal bacteremia and death. Twenty-three-valent pneumococcal... |
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SubjectTerms | Adult Antibodies Antibodies, Bacterial - blood Applied microbiology Bacteremia - immunology Bacteremia - therapy Bacteria Bacteriology Biological and medical sciences Disease risk Fundamental and applied biological sciences. Psychology Health care administration Heptavalent Pneumococcal Conjugate Vaccine Humans Immunoglobulin G - blood Infections Infectious diseases Male Medical genetics Medical sciences Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Microbiology Middle Aged Miscellaneous Pneumococcal Infections - immunology Pneumococcal Infections - therapy Pneumococcal vaccine Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Postoperative Complications Sepsis Splenectomy Streptococcus pneumoniae Streptococcus pneumoniae - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
Title | Administration of Protein-Conjugate Pneumococcal Vaccine to Patients Who Have Invasive Disease after Splenectomy Despite Their Having Received 23-Valent Pneumococcal Polysaccharide Vaccine |
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