Co-assembled whey protein and proanthocyanidins as a promising biocarrier for hydrophobic pterostilbene: Fabrication, characterization, and cellular antioxidant potential
The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocar...
Saved in:
| Published in | Journal of dairy science Vol. 107; no. 5; pp. 2690 - 2705 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.05.2024
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone, as determined by encapsulation efficiency and loading capacity assay, fluorescence quenching analysis, and molecular docking, whereas the assembly process was characterized by particle size and zeta potential, 3-dimensional fluorescence, and scanning electron microscopy. Circular dichroism and Fourier transform infrared spectroscopy spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the formation of nanocomplexes. Whey protein isolate acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing H2O2-induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification. |
|---|---|
| AbstractList | The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone, as determined by encapsulation efficiency and loading capacity assay, fluorescence quenching analysis, and molecular docking, whereas the assembly process was characterized by particle size and zeta potential, 3-dimensional fluorescence, and scanning electron microscopy. Circular dichroism and Fourier transform infrared spectroscopy spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the formation of nanocomplexes. Whey protein isolate acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing H2O2-induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification. The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone, as determined by encapsulation efficiency and loading capacity assay, fluorescence quenching analysis, and molecular docking, whereas the assembly process was characterized by particle size and zeta potential, 3-dimensional fluorescence, and scanning electron microscopy. Circular dichroism and Fourier transform infrared spectroscopy spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the formation of nanocomplexes. Whey protein isolate acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing H O -induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification. The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone as determined by encapsulation efficiency (EE) and loading capacity (LC) assay, fluorescence quenching analysis and molecular docking, while assembly process was characterized by particle size and zeta-potential, 3D fluorescence and SEM. CD and FTIR spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the nanocomplexes formation. WPI acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing ABTS and DPPH radical scavenging and reducing H₂O₂-induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification. The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone, as determined by encapsulation efficiency and loading capacity assay, fluorescence quenching analysis, and molecular docking, whereas the assembly process was characterized by particle size and zeta potential, 3-dimensional fluorescence, and scanning electron microscopy. Circular dichroism and Fourier transform infrared spectroscopy spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the formation of nanocomplexes. Whey protein isolate acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing H2O2-induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification.The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed by co-assembly of whey protein isolate (WPI) and hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such biocarrier has superior affinity for PTE than WPI alone, as determined by encapsulation efficiency and loading capacity assay, fluorescence quenching analysis, and molecular docking, whereas the assembly process was characterized by particle size and zeta potential, 3-dimensional fluorescence, and scanning electron microscopy. Circular dichroism and Fourier transform infrared spectroscopy spectra confirmed the α-helix to β-sheet and random coil transition of proteins during the formation of nanocomplexes. Whey protein isolate acted as a mediator through altering the binding mode of PC and PTE, allowing them to perform significant synergistic effects in enhancing 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing H2O2-induced cell damage. This research may serve to develop new protein/polyphenol co-loading systems and offer a reliable nutritional fortification. |
| Author | Wang, Qi Zhong, Weigang Li, Min Deng, Xuming Shen, Xue |
| Author_xml | – sequence: 1 givenname: Weigang surname: Zhong fullname: Zhong, Weigang organization: Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun, Jilin, 130062, China – sequence: 2 givenname: Qi surname: Wang fullname: Wang, Qi organization: Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun, Jilin, 130062, China – sequence: 3 givenname: Min surname: Li fullname: Li, Min organization: Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun, Jilin, 130062, China – sequence: 4 givenname: Xuming surname: Deng fullname: Deng, Xuming email: dengxm@jlu.edu.cn organization: Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, 130062, China – sequence: 5 givenname: Xue orcidid: 0000-0002-7145-7601 surname: Shen fullname: Shen, Xue email: shenxue417@163.com organization: Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun, Jilin, 130062, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37949399$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUk1vEzEQXaEimhauHJGPHNjgj_WuzQ1FFCpV4gJna_yxjaONHWwHCD-JX4k3CT0gVUiWxjN6bzye966aixCDa5qXBC8Z6cXbjc1LiilrKZOUP2kWhFPeMiLFRbPAmNIWM0wvm6ucNzUlFPNnzSUbZCeZlIvm9yq2kLPb6slZ9GPtDmiXYnE-IAh2vkMo62gOELz1ISOoZy5vffbhHmkfDaTkXUJjTGh9sCnu1lF7g3bFpZiLn7QL7h26AZ28geJjeIPMGhKYCvC_zpX5NeOmaT9Bqkkt_vS2RrSr09QUpufN0xGm7F6c43Xz9ebDl9Wn9u7zx9vV-7vWdIKVdrB01BR6q6HTMAphu54yAAKMiY70VHdDJxxgzkY8GIF7TC0jgxUSpOSGXTe3p742wkbtkt9COqgIXh0LMd0rSMWbySmugYqejZwI0umRSWf7vuN45D0zVPPa6_WpV93Yt73LRdW9zd-E4OI-K0Z4HQpzOvwXSoWQVWRO-gp9dYbu9dbZhxn_yloByxPAVAVycuMDhGA1-0ZV36jZN-rom0ro_iEYX47KlAR-epwmTjRX9fheTaCy8S4YZ31yptSF-ceofwDcwNz0 |
| CitedBy_id | crossref_primary_10_3168_jds_2024_25495 crossref_primary_10_1016_j_foodhyd_2023_109681 crossref_primary_10_1016_j_foodhyd_2024_110960 crossref_primary_10_1016_j_bioorg_2024_108104 crossref_primary_10_1016_j_foodhyd_2024_110538 crossref_primary_10_1016_j_ijbiomac_2025_140481 |
| Cites_doi | 10.1016/j.foodchem.2022.133455 10.1016/j.foodchem.2021.129622 10.1039/C8FO02246A 10.1016/j.idairyj.2021.105269 10.1039/C9FO01963D 10.1016/j.foodhyd.2022.107991 10.1016/j.foodhyd.2022.107895 10.1016/j.lwt.2022.113258 10.1016/j.foodhyd.2017.06.036 10.1021/bm050229c 10.1016/j.foodchem.2022.133262 10.1016/j.foodchem.2021.129768 10.1016/j.lwt.2020.109611 10.1016/j.fochx.2023.100664 10.1002/biof.1410 10.3390/molecules27196316 10.1039/D0FO00627K 10.1016/j.foodhyd.2022.108108 10.1016/j.foodchem.2021.131385 10.1002/pat.4676 10.1021/acs.jafc.1c00367 10.1021/acs.jafc.1c03699 10.1111/1541-4337.12629 10.1016/j.foodres.2013.02.009 10.1016/j.foodres.2023.112664 10.1016/j.foodchem.2020.128145 10.1039/C7FO00688H 10.1016/j.foodhyd.2019.01.031 10.1016/j.foodchem.2022.133496 10.1016/j.lwt.2018.04.051 10.1021/jf505694e 10.1016/j.neulet.2021.135793 10.1080/87559129.2021.1888970 10.1016/j.foodhyd.2019.105306 10.1016/j.ijbiomac.2020.04.128 10.1021/acs.jafc.1c05580 10.1021/acs.jafc.2c00398 10.1016/j.foodchem.2021.130603 10.1016/j.jmgm.2020.107532 10.1021/jf200907x 10.1074/jbc.M004752200 10.1146/annurev-food-032519-051729 10.1016/j.foodchem.2019.125097 |
| ContentType | Journal Article |
| Copyright | 2024 American Dairy Science Association The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Copyright_xml | – notice: 2024 American Dairy Science Association – notice: The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 7S9 L.6 DOA |
| DOI | 10.3168/jds.2023-23925 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | PubMed AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture |
| EISSN | 1525-3198 |
| EndPage | 2705 |
| ExternalDocumentID | oai_doaj_org_article_5ba2863f51814bf39ed66450f563c2b5 37949399 10_3168_jds_2023_23925 S0022030223007993 |
| Genre | Journal Article |
| GroupedDBID | --- --K -~X .GJ 0R~ 0SF 186 18M 1B1 29K 2WC 36B 3V. 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 7X2 7X7 7XC 88E 8FE 8FG 8FH 8FI 8FJ 8FW 8R4 8R5 8VB AABVA AAEDT AAEDW AAFTH AAIAV AALRI AAQFI AAQXK AAWRB AAXUO ABCQX ABJCF ABJNI ABUWG ABVKL ACGFO ACGFS ACIWK ADBBV ADMUD ADPAM AEGXH AENEX AESVU AFKRA AFKWA AFRAH AFTJW AGZHU AHMBA AI. AIAGR AITUG AKRWK AKVCP ALMA_UNASSIGNED_HOLDINGS ALXNB AMRAJ ASPBG ATCPS AVWKF AZFZN BELOY BENPR BGLVJ BHPHI BPHCQ BVXVI C1A CCPQU CS3 D-I DU5 E3Z EBS EBU EDH EJD EMB F5P FDB FEDTE FGOYB FYGXN FYUFA GBLVA GROUPED_DOAJ GX1 HCIFZ HMCUK HVGLF HZ~ K1G L6V L7B M0K M1P M41 M7S N9A NCXOZ NHB O9- OK1 P2P PATMY PQQKQ PROAC PSQYO PTHSS PYCSY Q2X QII QWB R2- ROL RWL S0X SEL SES SSZ SV3 TAE TDS TWZ U5U UHB UKHRP VH1 WOQ XH2 XOL ZGI ZL0 ZXP ~KM AAFWJ AAHBH AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADMHG ADNMO ADVLN AEUPX AEUYN AFJKZ AFPKN AFPUW AGQPQ AIGII AKBMS AKYEP ALIPV APXCP CITATION PHGZM PHGZT NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c483t-7d2fb2a6dba4baf88d4623aa1a3384162b4748ea053f07c80602d317d89a995c3 |
| IEDL.DBID | DOA |
| ISSN | 0022-0302 1525-3198 |
| IngestDate | Wed Aug 27 01:30:18 EDT 2025 Fri Jul 11 09:17:18 EDT 2025 Thu Jul 10 22:38:33 EDT 2025 Thu Apr 03 07:06:00 EDT 2025 Thu Apr 24 23:10:44 EDT 2025 Tue Jul 01 04:02:40 EDT 2025 Sat Apr 20 15:59:13 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | nanocomplexes whey protein co-assembly proanthocyanidins pterostilbene |
| Language | English |
| License | This is an open access article under the CC BY license. The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c483t-7d2fb2a6dba4baf88d4623aa1a3384162b4748ea053f07c80602d317d89a995c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-7145-7601 |
| OpenAccessLink | https://doaj.org/article/5ba2863f51814bf39ed66450f563c2b5 |
| PMID | 37949399 |
| PQID | 2889239516 |
| PQPubID | 23479 |
| PageCount | 16 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_5ba2863f51814bf39ed66450f563c2b5 proquest_miscellaneous_3153840527 proquest_miscellaneous_2889239516 pubmed_primary_37949399 crossref_primary_10_3168_jds_2023_23925 crossref_citationtrail_10_3168_jds_2023_23925 elsevier_sciencedirect_doi_10_3168_jds_2023_23925 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-05-01 |
| PublicationDateYYYYMMDD | 2024-05-01 |
| PublicationDate_xml | – month: 05 year: 2024 text: 2024-05-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of dairy science |
| PublicationTitleAlternate | J Dairy Sci |
| PublicationYear | 2024 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Koh, Ho, Pan (bib13) 2021; 69 Li, Zhao, Wang, Tang, Wu, Wu, Yu, Elfalleh (bib16) 2020; 98 Silva, Reboredo-Rodríguez, Süntar, Sureda, Belwal, Loizzo, Tundis, Sobarzo-Sanchez, Rastrelli, Forbes-Hernandez, Battino, Filosa, Daglia, Nabavi, Nabavi (bib40) 2020; 19 Dai, Chen, McClements, Hu, Ye, Liu, Li (bib5) 2019; 10 Li, Liu, Ma, Yang, Zhang, Zhang, Yu, Du (bib17) 2022; 394 Qie, Chen, Quan, Wang, Zeng, Qin, Chen, He (bib35) 2020; 11 de Mejia, Zhang, Penta, Eroglu, Lila (bib6) 2020; 11 Gong, Guo, Wang, Huang, Zhu (bib8) 2023; 167 Carballo, Haas, Krueger, Reed (bib2) 2017; 8 Parolia, Maley, Sammynaiken, Green, Nickerson, Ghosh (bib32) 2022; 367 Huang, Liu, Hsia, Fong, Hsia, Tran, Velusamy, Yang, Sheu (bib12) 2021; 69 Qi, Liu, Ren, Zhu, Wang, Zhang, Wu, Yuan, Yan, Liu (bib34) 2023; 18 Masters, Eagon, Heying (bib26) 2020; 96 Razzak, Lee, Choi (bib37) 2019; 91 Ren, Liu, Wang, Liu, Zhang, Wu, Zhang, Han, Liu (bib38) 2022; 371 Araújo, Bourbon, Simões, Vicente, Coutinho, Ramos (bib1) 2020; 11 Liu, Yang, Liu, Meng, Zhou, Zhang, Blanchard (bib24) 2019; 299 Li, Dai, Chen, Li, Li, Liu, McClements (bib15) 2021; 339 Meng, Li (bib27) 2021; 364 Ozdal, Capanoglu, Altay (bib30) 2013; 51 Olatujoye, Methven, Jauregi (bib29) 2020; 130 Hou, Wang (bib11) 2022; 38 Lu, Zhao, Wang, Zhang, Wang (bib25) 2022; 132 Pan, Qin, Liu, Wang (bib31) 2011; 59 Chrysina, Brew, Acharya (bib3) 2000; 275 Nagarajan, Mohandas, Ganesan, Xu, Ramkumar (bib28) 2022; 27 Penalva, Esparza, Larraneta, González-Navarro, Gamazo, Irache (bib33) 2015; 63 Liu, Li, Yang, Xiong, Sun (bib21) 2017; 73 Zhao, Chen, Ashaolu (bib44) 2022; 126 Liang, Han, Han, Wu, Zhao, Fu, Wang, Han, Niu (bib19) 2021; 359 He, Dong, Li, Wang, Fu, Shen (bib9) 2018; 17 He, Guo, Ma, Li, Kang, Zhang, Gao, Liu, Chen, Kang (bib10) 2021; 750 Kong, Kang, Zhang, Jiang, Liu, Yang, Cao, Zheng, Shao, Yue (bib14) 2022; 394 Wang, Sang (bib41) 2018; 44 Liu, Sun, Cui, Cheng, Killpartrik, Kemp, Guo (bib23) 2022; 160 Razzak, Cho (bib36) 2022; 133 Roufik, Gauthier, Leng, Turgeon (bib39) 2006; 7 Xu, Zhao, Bian, Yang, Han, Xu, Zhou (bib42) 2018; 95 Zhang, Yang, Wang, Wang, Wang, Chang, Liu, Wang (bib43) 2022; 391 Farooq, Aquib, Ghayas, Bushra, Haleem Khan, Parveen, Wang (bib7) 2019; 30 Lila, Hoskin, Grace, Xiong, Strauch, Ferruzzi, Iorizzo, Kay (bib20) 2022; 70 Liu, Chen, Qin, Jiang, Zhang (bib22) 2020; 158 Dai, Liao, Wang, Tian, Tong, Lyu, Cheng, Miao, Qi, Jiang, Wang (bib4) 2023; 135 Liang, Su, Zhao, Li, Hua, Miao, Tan (bib18) 2022; 70 Araújo (10.3168/jds.2023-23925_bib1) 2020; 11 Dai (10.3168/jds.2023-23925_bib5) 2019; 10 Liu (10.3168/jds.2023-23925_bib23) 2022; 160 Razzak (10.3168/jds.2023-23925_bib37) 2019; 91 Kong (10.3168/jds.2023-23925_bib14) 2022; 394 Liang (10.3168/jds.2023-23925_bib19) 2021; 359 Liu (10.3168/jds.2023-23925_bib21) 2017; 73 Zhao (10.3168/jds.2023-23925_bib44) 2022; 126 Pan (10.3168/jds.2023-23925_bib31) 2011; 59 Masters (10.3168/jds.2023-23925_bib26) 2020; 96 Meng (10.3168/jds.2023-23925_bib27) 2021; 364 Ozdal (10.3168/jds.2023-23925_bib30) 2013; 51 Li (10.3168/jds.2023-23925_bib17) 2022; 394 Dai (10.3168/jds.2023-23925_bib4) 2023; 135 Nagarajan (10.3168/jds.2023-23925_bib28) 2022; 27 Huang (10.3168/jds.2023-23925_bib12) 2021; 69 Wang (10.3168/jds.2023-23925_bib41) 2018; 44 Farooq (10.3168/jds.2023-23925_bib7) 2019; 30 Razzak (10.3168/jds.2023-23925_bib36) 2022; 133 Liang (10.3168/jds.2023-23925_bib18) 2022; 70 Ren (10.3168/jds.2023-23925_bib38) 2022; 371 de Mejia (10.3168/jds.2023-23925_bib6) 2020; 11 He (10.3168/jds.2023-23925_bib10) 2021; 750 Lila (10.3168/jds.2023-23925_bib20) 2022; 70 Hou (10.3168/jds.2023-23925_bib11) 2022; 38 Liu (10.3168/jds.2023-23925_bib22) 2020; 158 Roufik (10.3168/jds.2023-23925_bib39) 2006; 7 Parolia (10.3168/jds.2023-23925_bib32) 2022; 367 Li (10.3168/jds.2023-23925_bib16) 2020; 98 Qi (10.3168/jds.2023-23925_bib34) 2023; 18 Chrysina (10.3168/jds.2023-23925_bib3) 2000; 275 Silva (10.3168/jds.2023-23925_bib40) 2020; 19 He (10.3168/jds.2023-23925_bib9) 2018; 17 Xu (10.3168/jds.2023-23925_bib42) 2018; 95 Zhang (10.3168/jds.2023-23925_bib43) 2022; 391 Qie (10.3168/jds.2023-23925_bib35) 2020; 11 Carballo (10.3168/jds.2023-23925_bib2) 2017; 8 Olatujoye (10.3168/jds.2023-23925_bib29) 2020; 130 Lu (10.3168/jds.2023-23925_bib25) 2022; 132 Penalva (10.3168/jds.2023-23925_bib33) 2015; 63 Koh (10.3168/jds.2023-23925_bib13) 2021; 69 Li (10.3168/jds.2023-23925_bib15) 2021; 339 Gong (10.3168/jds.2023-23925_bib8) 2023; 167 Liu (10.3168/jds.2023-23925_bib24) 2019; 299 |
| References_xml | – volume: 11 start-page: 305 year: 2020 end-page: 317 ident: bib1 article-title: Physicochemical characterisation and release behaviour of curcumin-loaded lactoferrin nanohydrogels into food simulants publication-title: Food Funct. – volume: 339 year: 2021 ident: bib15 article-title: Protein-polyphenol functional ingredients: The foaming properties of lactoferrin are enhanced by forming complexes with procyanidin publication-title: Food Chem. – volume: 91 start-page: 290 year: 2019 end-page: 300 ident: bib37 article-title: Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin publication-title: Food Hydrocoll. – volume: 275 start-page: 37021 year: 2000 end-page: 37029 ident: bib3 article-title: Crystal structures of apo- and holo-bovine α-Lactalbumin at 2.2-Å resolution reveal an effect of calcium on inter-lobe interactions publication-title: J. Biol. Chem. – volume: 133 year: 2022 ident: bib36 article-title: Molecular characterization of capsaicin binding interactions with ovalbumin and casein publication-title: Food Hydrocoll. – volume: 11 start-page: 3867 year: 2020 end-page: 3878 ident: bib35 article-title: Analysis of β-lactoglobulin–epigallocatechin gallate interactions: the antioxidant capacity and effects of polyphenols under different heating conditions in polyphenolic–protein interactions publication-title: Food Funct. – volume: 70 start-page: 13017 year: 2022 end-page: 13026 ident: bib20 article-title: Boosting the bioaccessibility of dietary bioactives by delivery as protein–polyphenol aggregate particles publication-title: J. Agric. Food Chem. – volume: 132 year: 2022 ident: bib25 article-title: Deciphering the non-covalent binding patterns of three whey proteins with rosmarinic acid by multi-spectroscopic, molecular docking and molecular dynamics simulation approaches publication-title: Food Hydrocoll. – volume: 371 year: 2022 ident: bib38 article-title: Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin publication-title: Food Chem. – volume: 10 start-page: 765 year: 2019 end-page: 774 ident: bib5 article-title: Protein–polyphenol interactions enhance the antioxidant capacity of phenolics: Analysis of rice glutelin–procyanidin dimer interactions publication-title: Food Funct. – volume: 70 start-page: 124 year: 2022 end-page: 135 ident: bib18 article-title: Microfluidic fabrication of pH-responsive nanoparticles for encapsulation and colon-target release of fucoxanthin publication-title: J. Agric. Food Chem. – volume: 367 year: 2022 ident: bib32 article-title: Structure—Functionality of lentil protein-polyphenol conjugates publication-title: Food Chem. – volume: 63 start-page: 5603 year: 2015 end-page: 5611 ident: bib33 article-title: Zein-based nanoparticles improve the oral bioavailability of resveratrol and its anti-inflammatory effects in a mouse model of endotoxic Shock publication-title: J. Agric. Food Chem. – volume: 19 start-page: 3191 year: 2020 end-page: 3218 ident: bib40 article-title: Evaluation of the status quo of polyphenols analysis: Part I—Phytochemistry, bioactivity, interactions, and industrial uses publication-title: Compr. Rev. Food Sci. Food Saf. – volume: 364 year: 2021 ident: bib27 article-title: Conformational changes and functional properties of whey protein isolate-polyphenol complexes formed by non-covalent interaction publication-title: Food Chem. – volume: 44 start-page: 16 year: 2018 end-page: 25 ident: bib41 article-title: Metabolism and pharmacokinetics of resveratrol and pterostilbene publication-title: Biofactors – volume: 8 start-page: 3374 year: 2017 end-page: 3382 ident: bib2 article-title: Cranberry Proanthocyanidins—Protein complexes for macrophage activation publication-title: Food Funct. – volume: 69 start-page: 4697 year: 2021 end-page: 4707 ident: bib12 article-title: Pterostilbene, a dimethylether analogue of resveratrol, possesses high potency in the prevention of platelet activation in humans and the reduction of vascular thrombosis in mice publication-title: J. Agric. Food Chem. – volume: 38 start-page: 738 year: 2022 end-page: 752 ident: bib11 article-title: Application of nanotechnology to enhance adsorption and bioavailability of procyanidins: A review publication-title: Food Rev. Int. – volume: 27 year: 2022 ident: bib28 article-title: New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects publication-title: Molecules – volume: 7 start-page: 419 year: 2006 end-page: 426 ident: bib39 article-title: Thermodynamics of binding interactions between bovine β-lactoglobulin A and the antihypertensive peptide β-Lg f142–148 publication-title: Biomacromolecules – volume: 98 year: 2020 ident: bib16 article-title: Effects of (+)-catechin on a rice bran protein oil-in-water emulsion: Droplet size, zeta-potential, emulsifying properties, and rheological behavior publication-title: Food Hydrocoll. – volume: 359 year: 2021 ident: bib19 article-title: Novel strategy of natural antioxidant nutrition quality evaluation in food: Oxidation resistance mechanism and synergistic effects investigation publication-title: Food Chem. – volume: 96 year: 2020 ident: bib26 article-title: Evaluation of consensus scoring methods for AutoDock Vina, smina and idock publication-title: J. Mol. Graph. Model. – volume: 126 year: 2022 ident: bib44 article-title: Whey proteins and peptides in health-promoting functions—A review publication-title: Int. Dairy J. – volume: 11 start-page: 145 year: 2020 end-page: 182 ident: bib6 article-title: The colors of health: Chemistry, bioactivity, and market demand for colorful foods and natural food sources of colorants publication-title: Annu. Rev. Food Sci. Technol. – volume: 73 start-page: 74 year: 2017 end-page: 89 ident: bib21 article-title: Fabrication and characterization of biocompatible hybrid nanoparticles from spontaneous co-assembly of casein/gliadin and proanthocyanidin publication-title: Food Hydrocoll. – volume: 135 year: 2023 ident: bib4 article-title: Soy protein isolate-catechin non-covalent and covalent complexes: Focus on structure, aggregation, stability and in vitro digestion characteristics publication-title: Food Hydrocoll. – volume: 394 year: 2022 ident: bib14 article-title: The non-covalent interactions between whey protein and various food functional ingredients publication-title: Food Chem. – volume: 130 year: 2020 ident: bib29 article-title: Effect of β-lactoglobulin on perception of astringency in red wine as measured by sequential profiling publication-title: Lebensm. Wiss. Technol. – volume: 30 start-page: 2183 year: 2019 end-page: 2191 ident: bib7 article-title: Whey protein: A functional and promising material for drug delivery systems recent developments and future prospects publication-title: Polym. Adv. Technol. – volume: 51 start-page: 954 year: 2013 end-page: 970 ident: bib30 article-title: A review on protein–phenolic interactions and associated changes publication-title: Food Res. Int. – volume: 59 start-page: 6650 year: 2011 end-page: 6656 ident: bib31 article-title: Characterizing the interaction between tartrazine and two serum albumins by a hybrid spectroscopic approach publication-title: J. Agric. Food Chem. – volume: 750 year: 2021 ident: bib10 article-title: Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway publication-title: Neurosci. Lett. – volume: 69 start-page: 10036 year: 2021 end-page: 10057 ident: bib13 article-title: Recent advances in health benefits of stilbenoids publication-title: J. Agric. Food Chem. – volume: 394 year: 2022 ident: bib17 article-title: Co-assembly of egg white-derived peptides and protein-polysaccharide complexes for curcumin encapsulation: The enhancement of stability, redispersibility, and bioactivity publication-title: Food Chem. – volume: 299 year: 2019 ident: bib24 article-title: Fabrication, structure, and function evaluation of the ferritin based nano-carrier for food bioactive compounds publication-title: Food Chem. – volume: 95 start-page: 209 year: 2018 end-page: 215 ident: bib42 article-title: Structural and solubility properties of pale, soft and exudative (PSE)-like chicken breast myofibrillar protein: Effect of glycosylation publication-title: Lebensm. Wiss. Technol. – volume: 391 year: 2022 ident: bib43 article-title: Proanthocyanidin B2 and transglutaminase synergistically improves gel properties of oxidized myofibrillar proteins publication-title: Food Chem. – volume: 167 year: 2023 ident: bib8 article-title: Construction of high internal phase Pickering emulsions using cold plasma modified soy protein isolate-proanthocyanidin complex publication-title: Food Res. Int. – volume: 158 start-page: 461 year: 2020 end-page: 470 ident: bib22 article-title: Zein/fucoidan-based composite nanoparticles for the encapsulation of pterostilbene: Preparation, characterization, physicochemical stability, and formation mechanism publication-title: Int. J. Biol. Macromol. – volume: 17 start-page: 4406 year: 2018 end-page: 4414 ident: bib9 article-title: Pterostilbene inhibits reactive oxygen species production and apoptosis in primary spinal cord neurons by activating autophagy via the mechanistic target of rapamycin signaling pathway publication-title: Mol. Med. Rep. – volume: 160 year: 2022 ident: bib23 article-title: Characterization, antioxidant capacity, and bioaccessibility of coenzyme Q10 loaded whey protein nanoparticles publication-title: Lebensm. Wiss. Technol. – volume: 18 year: 2023 ident: bib34 article-title: Effects of combined binding of chlorogenic acid/caffeic acid and gallic acid to trypsin on their synergistic antioxidant activity, enzyme activity and stability publication-title: Food Chem. X – volume: 394 year: 2022 ident: 10.3168/jds.2023-23925_bib14 article-title: The non-covalent interactions between whey protein and various food functional ingredients publication-title: Food Chem. doi: 10.1016/j.foodchem.2022.133455 – volume: 364 year: 2021 ident: 10.3168/jds.2023-23925_bib27 article-title: Conformational changes and functional properties of whey protein isolate-polyphenol complexes formed by non-covalent interaction publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.129622 – volume: 10 start-page: 765 year: 2019 ident: 10.3168/jds.2023-23925_bib5 article-title: Protein–polyphenol interactions enhance the antioxidant capacity of phenolics: Analysis of rice glutelin–procyanidin dimer interactions publication-title: Food Funct. doi: 10.1039/C8FO02246A – volume: 126 year: 2022 ident: 10.3168/jds.2023-23925_bib44 article-title: Whey proteins and peptides in health-promoting functions—A review publication-title: Int. Dairy J. doi: 10.1016/j.idairyj.2021.105269 – volume: 11 start-page: 305 year: 2020 ident: 10.3168/jds.2023-23925_bib1 article-title: Physicochemical characterisation and release behaviour of curcumin-loaded lactoferrin nanohydrogels into food simulants publication-title: Food Funct. doi: 10.1039/C9FO01963D – volume: 133 year: 2022 ident: 10.3168/jds.2023-23925_bib36 article-title: Molecular characterization of capsaicin binding interactions with ovalbumin and casein publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2022.107991 – volume: 132 year: 2022 ident: 10.3168/jds.2023-23925_bib25 article-title: Deciphering the non-covalent binding patterns of three whey proteins with rosmarinic acid by multi-spectroscopic, molecular docking and molecular dynamics simulation approaches publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2022.107895 – volume: 160 year: 2022 ident: 10.3168/jds.2023-23925_bib23 article-title: Characterization, antioxidant capacity, and bioaccessibility of coenzyme Q10 loaded whey protein nanoparticles publication-title: Lebensm. Wiss. Technol. doi: 10.1016/j.lwt.2022.113258 – volume: 73 start-page: 74 year: 2017 ident: 10.3168/jds.2023-23925_bib21 article-title: Fabrication and characterization of biocompatible hybrid nanoparticles from spontaneous co-assembly of casein/gliadin and proanthocyanidin publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2017.06.036 – volume: 7 start-page: 419 year: 2006 ident: 10.3168/jds.2023-23925_bib39 article-title: Thermodynamics of binding interactions between bovine β-lactoglobulin A and the antihypertensive peptide β-Lg f142–148 publication-title: Biomacromolecules doi: 10.1021/bm050229c – volume: 391 year: 2022 ident: 10.3168/jds.2023-23925_bib43 article-title: Proanthocyanidin B2 and transglutaminase synergistically improves gel properties of oxidized myofibrillar proteins publication-title: Food Chem. doi: 10.1016/j.foodchem.2022.133262 – volume: 359 year: 2021 ident: 10.3168/jds.2023-23925_bib19 article-title: Novel strategy of natural antioxidant nutrition quality evaluation in food: Oxidation resistance mechanism and synergistic effects investigation publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.129768 – volume: 130 year: 2020 ident: 10.3168/jds.2023-23925_bib29 article-title: Effect of β-lactoglobulin on perception of astringency in red wine as measured by sequential profiling publication-title: Lebensm. Wiss. Technol. doi: 10.1016/j.lwt.2020.109611 – volume: 18 year: 2023 ident: 10.3168/jds.2023-23925_bib34 article-title: Effects of combined binding of chlorogenic acid/caffeic acid and gallic acid to trypsin on their synergistic antioxidant activity, enzyme activity and stability publication-title: Food Chem. X doi: 10.1016/j.fochx.2023.100664 – volume: 44 start-page: 16 year: 2018 ident: 10.3168/jds.2023-23925_bib41 article-title: Metabolism and pharmacokinetics of resveratrol and pterostilbene publication-title: Biofactors doi: 10.1002/biof.1410 – volume: 27 year: 2022 ident: 10.3168/jds.2023-23925_bib28 article-title: New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects publication-title: Molecules doi: 10.3390/molecules27196316 – volume: 11 start-page: 3867 year: 2020 ident: 10.3168/jds.2023-23925_bib35 article-title: Analysis of β-lactoglobulin–epigallocatechin gallate interactions: the antioxidant capacity and effects of polyphenols under different heating conditions in polyphenolic–protein interactions publication-title: Food Funct. doi: 10.1039/D0FO00627K – volume: 135 year: 2023 ident: 10.3168/jds.2023-23925_bib4 article-title: Soy protein isolate-catechin non-covalent and covalent complexes: Focus on structure, aggregation, stability and in vitro digestion characteristics publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2022.108108 – volume: 371 year: 2022 ident: 10.3168/jds.2023-23925_bib38 article-title: Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.131385 – volume: 30 start-page: 2183 year: 2019 ident: 10.3168/jds.2023-23925_bib7 article-title: Whey protein: A functional and promising material for drug delivery systems recent developments and future prospects publication-title: Polym. Adv. Technol. doi: 10.1002/pat.4676 – volume: 69 start-page: 4697 year: 2021 ident: 10.3168/jds.2023-23925_bib12 article-title: Pterostilbene, a dimethylether analogue of resveratrol, possesses high potency in the prevention of platelet activation in humans and the reduction of vascular thrombosis in mice publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.1c00367 – volume: 69 start-page: 10036 year: 2021 ident: 10.3168/jds.2023-23925_bib13 article-title: Recent advances in health benefits of stilbenoids publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.1c03699 – volume: 19 start-page: 3191 year: 2020 ident: 10.3168/jds.2023-23925_bib40 article-title: Evaluation of the status quo of polyphenols analysis: Part I—Phytochemistry, bioactivity, interactions, and industrial uses publication-title: Compr. Rev. Food Sci. Food Saf. doi: 10.1111/1541-4337.12629 – volume: 51 start-page: 954 year: 2013 ident: 10.3168/jds.2023-23925_bib30 article-title: A review on protein–phenolic interactions and associated changes publication-title: Food Res. Int. doi: 10.1016/j.foodres.2013.02.009 – volume: 167 year: 2023 ident: 10.3168/jds.2023-23925_bib8 article-title: Construction of high internal phase Pickering emulsions using cold plasma modified soy protein isolate-proanthocyanidin complex publication-title: Food Res. Int. doi: 10.1016/j.foodres.2023.112664 – volume: 339 year: 2021 ident: 10.3168/jds.2023-23925_bib15 article-title: Protein-polyphenol functional ingredients: The foaming properties of lactoferrin are enhanced by forming complexes with procyanidin publication-title: Food Chem. doi: 10.1016/j.foodchem.2020.128145 – volume: 17 start-page: 4406 year: 2018 ident: 10.3168/jds.2023-23925_bib9 article-title: Pterostilbene inhibits reactive oxygen species production and apoptosis in primary spinal cord neurons by activating autophagy via the mechanistic target of rapamycin signaling pathway publication-title: Mol. Med. Rep. – volume: 8 start-page: 3374 year: 2017 ident: 10.3168/jds.2023-23925_bib2 article-title: Cranberry Proanthocyanidins—Protein complexes for macrophage activation publication-title: Food Funct. doi: 10.1039/C7FO00688H – volume: 91 start-page: 290 year: 2019 ident: 10.3168/jds.2023-23925_bib37 article-title: Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2019.01.031 – volume: 394 year: 2022 ident: 10.3168/jds.2023-23925_bib17 article-title: Co-assembly of egg white-derived peptides and protein-polysaccharide complexes for curcumin encapsulation: The enhancement of stability, redispersibility, and bioactivity publication-title: Food Chem. doi: 10.1016/j.foodchem.2022.133496 – volume: 95 start-page: 209 year: 2018 ident: 10.3168/jds.2023-23925_bib42 article-title: Structural and solubility properties of pale, soft and exudative (PSE)-like chicken breast myofibrillar protein: Effect of glycosylation publication-title: Lebensm. Wiss. Technol. doi: 10.1016/j.lwt.2018.04.051 – volume: 63 start-page: 5603 year: 2015 ident: 10.3168/jds.2023-23925_bib33 article-title: Zein-based nanoparticles improve the oral bioavailability of resveratrol and its anti-inflammatory effects in a mouse model of endotoxic Shock publication-title: J. Agric. Food Chem. doi: 10.1021/jf505694e – volume: 750 year: 2021 ident: 10.3168/jds.2023-23925_bib10 article-title: Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2021.135793 – volume: 38 start-page: 738 issue: Sup1 year: 2022 ident: 10.3168/jds.2023-23925_bib11 article-title: Application of nanotechnology to enhance adsorption and bioavailability of procyanidins: A review publication-title: Food Rev. Int. doi: 10.1080/87559129.2021.1888970 – volume: 98 year: 2020 ident: 10.3168/jds.2023-23925_bib16 article-title: Effects of (+)-catechin on a rice bran protein oil-in-water emulsion: Droplet size, zeta-potential, emulsifying properties, and rheological behavior publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2019.105306 – volume: 158 start-page: 461 year: 2020 ident: 10.3168/jds.2023-23925_bib22 article-title: Zein/fucoidan-based composite nanoparticles for the encapsulation of pterostilbene: Preparation, characterization, physicochemical stability, and formation mechanism publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.04.128 – volume: 70 start-page: 124 year: 2022 ident: 10.3168/jds.2023-23925_bib18 article-title: Microfluidic fabrication of pH-responsive nanoparticles for encapsulation and colon-target release of fucoxanthin publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.1c05580 – volume: 70 start-page: 13017 year: 2022 ident: 10.3168/jds.2023-23925_bib20 article-title: Boosting the bioaccessibility of dietary bioactives by delivery as protein–polyphenol aggregate particles publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.2c00398 – volume: 367 year: 2022 ident: 10.3168/jds.2023-23925_bib32 article-title: Structure—Functionality of lentil protein-polyphenol conjugates publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.130603 – volume: 96 year: 2020 ident: 10.3168/jds.2023-23925_bib26 article-title: Evaluation of consensus scoring methods for AutoDock Vina, smina and idock publication-title: J. Mol. Graph. Model. doi: 10.1016/j.jmgm.2020.107532 – volume: 59 start-page: 6650 year: 2011 ident: 10.3168/jds.2023-23925_bib31 article-title: Characterizing the interaction between tartrazine and two serum albumins by a hybrid spectroscopic approach publication-title: J. Agric. Food Chem. doi: 10.1021/jf200907x – volume: 275 start-page: 37021 year: 2000 ident: 10.3168/jds.2023-23925_bib3 article-title: Crystal structures of apo- and holo-bovine α-Lactalbumin at 2.2-Å resolution reveal an effect of calcium on inter-lobe interactions publication-title: J. Biol. Chem. doi: 10.1074/jbc.M004752200 – volume: 11 start-page: 145 year: 2020 ident: 10.3168/jds.2023-23925_bib6 article-title: The colors of health: Chemistry, bioactivity, and market demand for colorful foods and natural food sources of colorants publication-title: Annu. Rev. Food Sci. Technol. doi: 10.1146/annurev-food-032519-051729 – volume: 299 year: 2019 ident: 10.3168/jds.2023-23925_bib24 article-title: Fabrication, structure, and function evaluation of the ferritin based nano-carrier for food bioactive compounds publication-title: Food Chem. doi: 10.1016/j.foodchem.2019.125097 |
| SSID | ssj0021205 |
| Score | 2.4888873 |
| Snippet | The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2690 |
| SubjectTerms | antioxidant activity co-assembly dairy science encapsulation fluorescence hydrophilicity hydrophobicity nanocomplexes particle size proanthocyanidins pterostilbene whey protein whey protein isolate zeta potential |
| Title | Co-assembled whey protein and proanthocyanidins as a promising biocarrier for hydrophobic pterostilbene: Fabrication, characterization, and cellular antioxidant potential |
| URI | https://dx.doi.org/10.3168/jds.2023-23925 https://www.ncbi.nlm.nih.gov/pubmed/37949399 https://www.proquest.com/docview/2889239516 https://www.proquest.com/docview/3153840527 https://doaj.org/article/5ba2863f51814bf39ed66450f563c2b5 |
| Volume | 107 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9NAFB5kfdEH8W69LCMIvjhsOrdMfKuLZXHRB3Fx38LcYiM1Kdkua_1J_kq_SdLiPhRfhEKa4ZBMck7m-0578h1CXpnKhazSU1bwmDPJo2JFkVsmnTBeKZeFmN4d_vhJn5zJD-fq_K9WX6kmbJAHHm7ckXKWGy0qBSiSrhJFDFpLlVVKC89dr14KzNsmU2OqNeVD8WKqVUcY80GuMTVpOvoekko3F4yDGqhrcNSr9l9DpX2ss0ef-V1yZ6SNdDZM9x65EZv75PbsWzdKZ8QH5Pdxy8CE4w-3jIFeLeKG9iIMdUNtE9J3m4QC_MY2NQDrglp80jA8DfyirgasdamBHQWRpYtN6NrVonW1pyvc_BZrwdJhZXxL59Z14099b6jfKT7_GkfS2dL_AanAFTsY_FkHbOkKs8GuXT4kZ_P3X45P2NiJgXlpxJrlgVeOWx2clc5WxgQJ2mTt1CLDBaXjTubSRIsnuspybzKd8QBmEkxhi0J58YgcNG0TnxCqnat8RCLkeQUqF61SHimb0NY4HMNNCNs6pPSjTHnqlrEska4kB5ZwYJkcWPYOnJDXO_vVINCx1_Jd8u_OKglr9wMIt3IMt_Jf4TYh0210lCNHGbgHDlXvPfHLbRiVcGnygG1iewkbY0CwQXL1fhuRMAm0mucT8niIwd0lCKymBSjm0_9xac_ILcxZDtWcz8nBuruML8C41u6Q3Jydfv56etg_ZH8A1owr0A |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Co-assembled+whey+protein+and+proanthocyanidins+as+a+promising+biocarrier+for+hydrophobic+pterostilbene%3A+Fabrication%2C+characterization%2C+and+cellular+antioxidant+potential&rft.jtitle=Journal+of+dairy+science&rft.au=Zhong%2C+Weigang&rft.au=Wang%2C+Qi&rft.au=Li%2C+Min&rft.au=Deng%2C+Xuming&rft.date=2024-05-01&rft.eissn=1525-3198&rft.volume=107&rft.issue=5&rft.spage=2690&rft_id=info:doi/10.3168%2Fjds.2023-23925&rft_id=info%3Apmid%2F37949399&rft.externalDocID=37949399 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-0302&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-0302&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-0302&client=summon |