The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription - Wong, Matthew; Tee, Andrew E.L.; Milazzo, Giorgio; Bell, Jessica L.; Poulos, Rebecca C.; Atmadibrata, Bernard; Sun, Yuting; Jing, Duohui; Ho, Nicholas; Ling, Dora; Liu, Pei Yan; Zhang, Xu Dong; et al. (Cancer research (Chicago, Ill.), 2017)
Keywords: Animals; Antitumor agents; Cancer; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; DNA methylation; DNA Methylation - drug effects; Doxycycline; Enzyme Inhibitors - administration & dosage; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Histone H3; Histone methyltransferase; Histone-Lysine N-Methyltransferase - antagonists & inhibitors; Histone-Lysine N-Methyltransferase - genetics; Humans; Lysine; Methyltransferases - antagonists & inhibitors; Methyltransferases - genetics; Mice; Myc protein; MYCN gene; N-Myc protein; N-Myc Proto-Oncogene Protein - biosynthesis; N-Myc Proto-Oncogene Protein - genetics; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - genetics; Neuroblastoma - pathology; Neuroblasts; Promoter Regions, Genetic; Promoters; Protein expression; Proteins; Transcription activation; Transcription, Genetic; Tumorigenesis; Xenografts