Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling - Balducci, Martina; Pérez, Julia Tortajada; del Río, Cristina Trujillo; Pérez, Mar Collado; Carranza, Andrea del Valle; Gomez Escribano, Ana Pilar; Vázquez-Manrique, Rafael P.; Tarozzi, Andrea (International journal of molecular sciences, 2024)
Keywords: Aggregates; AMP-Activated Protein Kinases - metabolism; Animals; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; Cyclic adenylic acid; Degeneration; Disease prevention; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Genomes; Glutamine; Health aspects; Human subjects; Huntingtons disease; Isothiocyanates - pharmacology; Kinases; Nematodes; Nervous system; Organosulfur compounds; Peptides - metabolism; Peptides - pharmacology; Physiological aspects; Protein kinases; Proteins; Signal transduction; Signal Transduction - drug effects; Sulfides; Sulfoxides - pharmacology; Thiocyanates; Toxicity; Transcription factors; Worms; Young adults; Spain; Caenorhabditis elegans; AMPK; erucin; neuroprotection; polyQ toxicity; daf-16/FOXO