Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice

• Published in: Bone (New York, N.Y.) Vol. 167; no. C; p. 116646
• Main Authors: Cunningham, Hailey C., Orr, Sophie, Murugesh, Deepa K., Hsia, Allison W., Osipov, Benjamin, Go, Lauren, Wu, Po Hung, Wong, Alice, Loots, Gabriela G., Kazakia, Galateia J., Christiansen, Blaine A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023; Elsevier
• Subjects: Aging; Animals; Bone adaptation; Bone and Bones; Cortical Bone; Cortical porosity; Femur - metabolism; Hindlimb Suspension; Hindlimb unloading; Mice; Mice, Transgenic; Osteocytes; Osteocytes - metabolism; Hindlimb unloading; Bone adaptation; Aging; Cortical porosity; Osteocytes

Mechanical unloading causes rapid loss of bone structure and strength, which gradually recovers after resuming normal loading. However, it is not well established how this adaptation to unloading and reloading changes with age. Clinically, elderly patients are more prone to musculoskeletal injury an...