Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARδ

• Published in: International journal of molecular sciences Vol. 24; no. 14; p. 11600
• Main Authors: Shou, Jia-Wen, Shaw, Pang-Chui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.07.2023; MDPI
• Subjects: Adipocytes; Body fat; Cholesterol; COVID-19; Epidemics; Gastrointestinal surgery; Genes; Genetic aspects; Genetic engineering; Genetic transcription; Heme; Kinases; Lifestyles; Ligands; Lipids; Liver; Lorcaserin; Mediation; Metabolism; Obesity; Physiological aspects; Protein binding; Proteins; Scientific equipment and supplies industry; Traditional Chinese medicine; Triglycerides; Weight control; United States; China; adipogenesis; obesity; PPARδ; berberine

Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine. Coptidis Rhizoma is an herb used to clear heat and eliminate dampness in obesity and its complications. Berberine (BBR), the main active compound in Coptidis Rhizoma, shows anti-obesity effects. Peroxisome proliferator-a...