The PI3K/Akt/mTOR signaling pathway plays a role in regulating aconitine-induced autophagy in mouse liver

• Published in: Research in veterinary science Vol. 124; pp. 317 - 320
• Main Authors: Yang, Hanqi, Wang, Hui, Liu, Yanbing, Yang, Lin, Sun, Lu, Tian, Yanan, Zhao, Baoyu, Lu, Hao
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2019; Elsevier Limited
• Subjects: 1-Phosphatidylinositol 3-kinase; Aconitine; Aconitum; AKT protein; alkaloids; animal models; Apoptosis; arrhythmia; Autophagy; Cell growth; Critical components; Kinases; Liver; Mice; Phagocytosis; Phosphorylation; PI3K/Akt/mTOR signaling pathway; Proteins; Signal transduction; Signaling; Signs and symptoms; Time dependence; TOR protein; Toxicity; Veterinary medicine; Western blotting; China; PI3K/Akt/mTOR signaling pathway; p70S6K; PI3K; mTOR; Aconitum; 4E-BP1; Autophagy; Aconitine; ERK

Aconitine, a major aconitum alkaloid, is well known for its high toxicity that induces severe arrhythmias and neurological symptoms. One mechanism of aconitine-induced toxic responses is the induction of apoptosis. Apoptosis and autophagy are interconnected processes and the two pathways share criti...