Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus

• Published in: Virology (New York, N.Y.) Vol. 182; no. 2; pp. 635 - 643
• Main Authors: Montefiori, David C., Zhou, Jiying, Barnes, Brenda, Lake, Douglas, Hersh, Eban M., Masuho, Yasuhiko, Lefkowitz, Lewis B.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.06.1991; Elsevier
• Subjects: Adult; AIDS-Related Complex - immunology; AIDS/HIV; Antibodies, Monoclonal - immunology; Biological and medical sciences; Blotting, Western; Cross Reactions; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Gene Products, env - immunology; Gene Products, gag - immunology; HIV Antibodies - immunology; HIV Antigens - immunology; HIV-1 - immunology; HIV-1 - isolation & purification; Humans; Immunoglobulin Isotypes - immunology; In Vitro Techniques; Male; Microbiology; Middle Aged; Neutralization Tests; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; RNA-Directed DNA Polymerase - analysis; Virology; Immunoglobulins; Immune response; Antibody; Retroviridae; AIDS; Hemopathy; Indirect immunofluorescence; Infection; Virus; Viral disease; Immunoblotting assay; Lentivirinae; Human immunodeficiency virus; Clinical isolate; Humoral immunity; Neutralization

Human immunodeficiency virus type 1 (HIV-1) exhibits extensive genomic and antigenic diversity, which is thought to contribute to the failure of the host's immune response to control infection and prevent clinical progression. Part of this failure may be due to utilization by the virus of antig...