Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure

• Published in: International journal of cardiology Vol. 203; pp. 909 - 915
• Main Authors: Lopatin, Yuri M, Rosano, Giuseppe M.C, Fragasso, Gabriele, Lopaschuk, Gary D, Seferovic, Petar M, Gowdak, Luis Henrique W, Vinereanu, Dragos, Hamid, Magdy Abdel, Jourdain, Patrick, Ponikowski, Piotr
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 15.01.2016
• Subjects: Cardiac energy metabolism; Cardiovascular; Energy Metabolism; Heart failure; Heart Failure - drug therapy; Heart Failure - metabolism; Humans; Myocardium - metabolism; Prognosis; Treatment Outcome; Trimetazidine; Trimetazidine - pharmacokinetics; Vasodilator Agents - pharmacokinetics; Heart failure; Cardiac energy metabolism; Trimetazidine

Abstract Heart failure is a systemic and multiorgan syndrome with metabolic failure as a fundamental mechanism. As a consequence of its impaired metabolism, other processes are activated in the failing heart, further exacerbating the progression of heart failure. Recent evidence suggests that modula...