Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates

• Published in: Chemosphere (Oxford) Vol. 184; pp. 1194 - 1201
• Main Authors: Moreau, Marjory, Leonard, Jeremy, Phillips, Katherine A., Campbell, Jerry, Pendse, Salil N., Nicolas, Chantel, Phillips, Martin, Yoon, Miyoung, Tan, Yu-Mei, Smith, Sherrie, Pudukodu, Harish, Isaacs, Kristin, Clewell, Harvey
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2017
• Subjects: Dibutyl Phthalate; Diethylhexyl Phthalate - analogs & derivatives; Environment; Environmental Exposure - analysis; Environmental Exposure - statistics & numerical data; Environmental Pollutants - analysis; Environmental Pollutants - toxicity; Exposure; Humans; Nutrition Surveys; PBPK modeling; Phthalic Acids - analysis; Phthalic Acids - toxicity; Plethem; Prediction; Reverse dosimetry; Risk; Risk assessment; Risk Assessment - methods; Safety; Exposure; Reverse dosimetry; Risk assessment; Plethem; PBPK modeling; Prediction

A few different exposure prediction tools were evaluated for use in the new in vitro-based safety assessment paradigm using di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DnBP) as case compounds. Daily intake of each phthalate was estimated using both high-throughput (HT) prediction models...