Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis

• Published in: Biosensors & bioelectronics Vol. 25; no. 11; pp. 2414 - 2419
• Main Authors: Feng, Shangyuan, Chen, Rong, Lin, Juqiang, Pan, Jianji, Chen, Guannan, Li, Yongzeng, Cheng, Min, Huang, Zufang, Chen, Jiesi, Zeng, Haishan
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 15.07.2010; Elsevier
• Subjects: Biological and medical sciences; Biomarkers, Tumor - blood; Biosensing Techniques - methods; Biotechnology; Blood Chemical Analysis - methods; Blood plasma; Cancer detection; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Multivariate Analysis; Nasopharyngeal cancer; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - diagnosis; Reproducibility of Results; Sensitivity and Specificity; Silver nanoparticles; Spectrum Analysis, Raman - methods; Surface-enhanced Raman scattering (SERS); Surface-enhanced Raman scattering (SERS); Cancer detection; Nasopharyngeal cancer; Silver nanoparticles; Blood plasma; Nanoparticle; Malignant tumor; Multivariate analysis; Surface enhanced scattering; Silver; Surface Enhanced Raman Spectrometry; Detection; Cancer

A surface-enhanced Raman spectroscopy (SERS) method was developed for blood plasma biochemical analysis for the first time with the aim to develop a simple blood test for non-invasive nasopharyngeal cancer detection. Silver nanoparticles (Ag NP) as the SERS-active nanostructures were directly mixed...