Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 40; no. 9; p. 1103
• Main Authors: Silver, A A, Shytle, R D, Sheehan, K H, Sheehan, D V, Ramos, A, Sanberg, P R
• Format: Journal Article
• Language: English
• Published: United States 01.09.2001
• Subjects: Adolescent; Child; Comorbidity; Depression; Double-Blind Method; Female; Ganglionic Blockers - pharmacology; Heart Rate - drug effects; Humans; Male; Mecamylamine - pharmacology; Mood Disorders; Placebos; Severity of Illness Index; Tourette Syndrome - drug therapy; Treatment Outcome
• ISSN: 0890-8567
• DOI: 10.1097/00004583-200109000-00020

The safety and efficacy of mecamylamine as a monotherapy in children and adolescents with Tourette's disorder (TD) was investigated in an 8-week multicenter, double-blind, placebo-controlled study. Eligible subjects included subjects with TD (DSM-IV), with a naturalistic mix of comorbid diagnos...