Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses - Han, Ziying; Lu, Jianhong; Liu, Yuliang; Davis, Benjamin; Lee, Michael S.; Olson, Mark A.; Ruthel, Gordon; Freedman, Bruce D.; Schnell, Matthias J.; Wrobel, Jay E.; Reitz, Allen B.; Harty, Ronald N. (Journal of virology, 2014)
Keywords: Blotting, Western; Ebola virus; Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors; Endosomal Sorting Complexes Required for Transport - metabolism; Filovirus; Genetic Complementation Test; Humans; Marburg virus; Nedd4 Ubiquitin Protein Ligases; Pharmaceutical Preparations - metabolism; Protein Binding - drug effects; Rhabdovirus; RNA Virus Infections - drug therapy; RNA Virus Infections - virology; RNA Viruses - drug effects; RNA Viruses - physiology; RNA, Viral - genetics; Small Molecule Libraries; Structure-Activity Relationship; Ubiquitin-Protein Ligases - antagonists & inhibitors; Ubiquitin-Protein Ligases - metabolism; Vaccines and Antiviral Agents; Viral Matrix Proteins - antagonists & inhibitors; Viral Matrix Proteins - metabolism; Virion - drug effects; Virion - physiology; Virus Release - drug effects