Liver fibrosis is a common pathological change in the liver of dairy cows with fatty liver

• Published in: Journal of dairy science Vol. 106; no. 4; pp. 2700 - 2715
• Main Authors: Zhang, Cai, Shao, Qi, Liu, Mingchao, Wang, Xueying, Loor, Juan J., Jiang, Qianming, Cuan, Shunan, Li, Xinwei, Wang, Jianguo, Li, Yuanxiao, He, Lei, Huang, Yong, Liu, Guowen, Lei, Lin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023; Elsevier
• Subjects: actin; alanine transaminase; Animals; antioxidant activity; antioxidants; Antioxidants - metabolism; apoptosis; aspartate transaminase; biopsy; blood; catalase; Cattle; Cattle Diseases; collagen; Collagen Type I - metabolism; Cytokines - metabolism; dairy cow; dairy science; death; disulfides; extracellular matrix; Fatty Acids, Nonesterified; fatty liver; Fatty Liver - veterinary; Female; fibrosis; genes; glutathione; glutathione peroxidase; inflammation; interleukin-6; Lactation; liver; Liver - metabolism; liver cirrhosis; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Cirrhosis - veterinary; liver fibrosis; liver injury; malondialdehyde; metabolic diseases; milk; muscles; necrosis; neoplasms; oxidative stress; superoxide dismutase; triacylglycerols; Triglycerides - metabolism; liver fibrosis; liver injury; fatty liver; dairy cow

Fatty liver (i.e., hepatic lipidosis) is a prevalent metabolic disorder in dairy cows during the transition period, characterized by excess hepatic accumulation of triglyceride (TG), tissue dysfunction, and cell death. Detailed pathological changes, particularly hepatic fibrosis, during fatty liver...