IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in a...

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Published inCells (Basel, Switzerland) Vol. 9; no. 10; p. 2184
Main Authors Floss, Doreen M., Moll, Jens M., Scheller, Jürgen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 28.09.2020
MDPI
Subjects
Amino acid sequence
Autoimmune diseases
Chemical bonds
Clinical trials
Cytokines
Drug delivery
IL-12
IL-12 family cytokines
IL-23
Immune system
Immunosuppressive agents
Inflammation
Interleukin 12
Interleukin 23
Interleukins
Intracellular
Intracellular signalling
Mutation
Observations
Physiological aspects
Protein interaction
Quality control
Review
Signal transduction
signaling
Single-nucleotide polymorphism
Structure
Germany
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Abstract Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein–protein interactions. To understand the biology of IL-12 and IL-23 and to establish efficient targeting strategies structural knowledge about cytokines and respective receptors is crucial. A highly efficient therapy might be a combination of different drugs targeting extracellular cytokine:receptor assembly and intracellular signaling pathways.
AbstractList Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein–protein interactions. To understand the biology of IL-12 and IL-23 and to establish efficient targeting strategies structural knowledge about cytokines and respective receptors is crucial. A highly efficient therapy might be a combination of different drugs targeting extracellular cytokine:receptor assembly and intracellular signaling pathways.
Audience Academic
Author Floss, Doreen M.
Scheller, Jürgen
Moll, Jens M.
AuthorAffiliation Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, D-40225 Düsseldorf, Germany; jens.moll@uni-duesseldorf.de (J.M.M.); jscheller@uni-duesseldorf.de (J.S.)
AuthorAffiliation_xml – name: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, D-40225 Düsseldorf, Germany; jens.moll@uni-duesseldorf.de (J.M.M.); jscheller@uni-duesseldorf.de (J.S.)
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  givenname: Jürgen
  surname: Scheller
  fullname: Scheller, Jürgen
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Cites_doi 10.1016/j.immuni.2019.03.027
10.4049/jimmunol.146.9.3074
10.1038/cdd.2014.134
10.4049/jimmunol.158.9.4381
10.1016/j.molimm.2012.03.025
10.4049/jimmunol.165.5.2535
10.1007/s00011-012-0566-z
10.1074/jbc.M112.432955
10.1101/cshperspect.a028571
10.1007/s00277-008-0666-6
10.1210/jc.2007-2190
10.1111/j.1365-2567.2005.02257.x
10.1002/glia.20869
10.1038/s41575-018-0084-8
10.1016/j.cytogfr.2018.12.002
10.1038/ng.733
10.4049/jimmunol.1801603
10.1002/ijc.26130
10.1055/s-0036-1579739
10.4049/jimmunol.0902740
10.1016/S1074-7613(02)00324-2
10.1038/s41467-019-12006-x
10.1038/ni.2227
10.1073/pnas.94.22.12041
10.4049/jimmunol.155.9.4286
10.4049/jimmunol.148.11.3433
10.1126/science.1083901
10.1002/(SICI)1521-4141(199906)29:06<2007::AID-IMMU2007>3.0.CO;2-0
10.4049/jimmunol.168.11.5699
10.1073/pnas.0702388104
10.1371/journal.pone.0137801
10.1038/s41598-017-15173-3
10.4049/jimmunol.1500400
10.1371/journal.pone.0107990
10.1016/j.cell.2006.07.035
10.4049/jimmunol.153.1.128
10.1016/j.cytogfr.2015.07.013
10.4049/jimmunol.169.8.4388
10.1002/mc.20661
10.1074/jbc.M116.715870
10.1038/nature01355
10.4049/jimmunol.171.9.4485
10.1080/14740338.2020.1703946
10.1038/nature06306
10.3390/v11090772
10.1093/emboj/19.14.3530
10.1002/j.1460-2075.1995.tb07186.x
10.1091/mbc.E14-12-1645
10.1016/j.bbrc.2003.09.140
10.1038/nprot.2009.86
10.1080/13543784.2019.1597053
10.1016/S0092-8674(00)81168-X
10.1126/science.1948064
10.1101/cshperspect.a030338
10.1002/jcc.20084
10.1007/978-94-024-0921-5_8
10.1172/JCI126567
10.1073/pnas.92.16.7307
10.1006/abbi.1999.1302
10.1080/1744666X.2019.1544493
10.1101/cshperspect.a028415
10.1371/journal.pone.0089092
10.4049/jimmunol.176.9.5652
10.1073/pnas.87.17.6808
10.3389/fphar.2020.00129
10.1038/s41467-018-04454-8
10.1146/annurev-immunol-032713-120211
10.1086/511051
10.1038/ncomms6237
10.1126/science.1135245
10.1371/journal.pone.0025038
10.1084/jem.170.3.827
10.1016/j.cytogfr.2014.07.017
10.1002/eji.1830250133
10.1016/j.it.2006.11.002
10.1021/acsmedchemlett.8b00255
10.1016/j.clim.2019.108250
10.1038/icb.2015.77
10.1074/jbc.M112.436675
10.1016/j.ajhg.2009.01.026
10.1016/j.immuni.2019.03.011
10.1038/ni.2366
10.3389/fimmu.2019.00044
10.1126/science.1549776
10.1007/s00011-019-01235-x
10.1016/j.cytogfr.2019.05.007
10.4049/jimmunol.170.4.2153
10.1152/ajpregu.00540.2013
10.1016/j.smim.2013.12.004
10.1074/jbc.270.52.31249
10.4049/jimmunol.165.11.6221
10.1006/bbrc.1999.0479
10.4049/jimmunol.163.5.2902
10.3389/fimmu.2016.00479
10.1007/s12026-011-8209-y
10.1074/jbc.272.9.6073
10.1371/journal.pbio.3000646
10.1007/978-94-024-0921-5_6
10.1016/S0016-5085(17)30471-7
10.1074/jbc.M114.617597
10.1074/jbc.M112.432153
10.1016/j.cytogfr.2015.07.011
10.3390/cells9092044
10.1038/s41584-019-0294-7
10.1016/S1074-7613(00)00070-4
10.1172/JCI78085
10.1007/s00011-019-01296-y
10.1046/j.1471-4159.2003.01864.x
10.1080/08923973.2019.1610429
10.1002/pro.3519
10.1074/jbc.274.4.1875
10.1016/j.immuni.2017.12.008
10.1016/j.bcp.2019.03.026
10.1080/21645515.2017.1356498
10.1038/nature11984
10.1111/j.1365-2567.2008.02985.x
10.4049/jimmunol.0901464
10.1073/pnas.93.24.14002
10.1128/MCB.00014-17
10.1074/jbc.RA120.013935
10.4049/jimmunol.1400159
10.1016/j.jmb.2008.07.051
10.1074/jbc.M303168200
10.3389/fped.2019.00472
10.1038/ni.3691
10.1016/j.molimm.2008.06.029
10.1016/j.jmb.2008.08.001
10.1074/jbc.M117.782284
10.4049/jimmunol.1003244
10.1186/1471-2334-14-316
10.1073/pnas.88.10.4143
10.4049/jimmunol.171.12.6866
10.1080/1744666X.2018.1491308
10.4049/jimmunol.154.1.116
10.1016/j.bcp.2020.113928
10.1016/j.pharmthera.2018.07.003
10.1007/s10072-016-2496-y
10.1074/jbc.274.9.5755
10.1002/eji.201546095
10.1002/eji.201445403
10.1073/pnas.0600666103
10.1038/gene.2015.22
10.1074/jbc.M208586200
10.1101/cshperspect.a028530
10.1038/s41598-018-35188-8
10.1038/srep24491
10.1074/jbc.M112.390625
10.1074/jbc.M116.762021
10.1084/jem.176.5.1387
10.1146/annurev.immunol.021908.132710
10.1002/eji.1830230923
10.1016/j.cytogfr.2015.07.003
10.1182/blood-2011-11-392738
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References Yuan (ref_46) 2019; 41
ref_92
Korn (ref_96) 2009; 27
ref_138
Schoenhaut (ref_14) 1992; 148
Naeger (ref_119) 1999; 274
Burkett (ref_94) 2015; 125
Zou (ref_104) 1997; 272
ref_132
Yoon (ref_51) 2000; 19
Siupka (ref_80) 2015; 16
Yamamoto (ref_121) 2003; 310
Shimozato (ref_62) 2006; 117
Ling (ref_21) 1995; 154
Detry (ref_24) 2019; 165
Wang (ref_91) 1999; 29
Pflanz (ref_18) 2002; 16
Chen (ref_123) 2006; 103
Sospedra (ref_47) 2016; 36
Schroder (ref_68) 2015; 290
Wu (ref_128) 2013; 496
Cargill (ref_144) 2007; 80
Zabotti (ref_44) 2020; 19
Chua (ref_82) 1995; 155
Oyamada (ref_101) 2009; 183
Eyles (ref_122) 2002; 277
Ha (ref_64) 1999; 163
Yamamoto (ref_106) 1999; 257
Duerr (ref_143) 2006; 314
Yan (ref_37) 2018; 10
Chu (ref_134) 2012; 130
Tugues (ref_48) 2015; 22
Abdi (ref_23) 2014; 192
Chehboun (ref_25) 2017; 292
Cooper (ref_58) 2007; 28
Wolf (ref_11) 1991; 146
Rengaraju (ref_54) 1992; 176
Collison (ref_20) 2007; 450
Jana (ref_65) 2003; 86
Lupardus (ref_70) 2008; 382
Reitberger (ref_55) 2017; 292
ref_150
Cunningham (ref_77) 1991; 254
Quiniou (ref_155) 2014; 307
Safrany (ref_135) 2013; 62
Cheng (ref_156) 2017; 152
Wang (ref_16) 2016; 46
Lochmatter (ref_113) 2016; 6
Parham (ref_50) 2002; 168
Bloch (ref_89) 2018; 48
Russell (ref_63) 2003; 171
Oppmann (ref_9) 2000; 13
Gubler (ref_13) 1991; 88
Gorman (ref_103) 2019; 10
Boulanger (ref_73) 2003; 300
Gracey (ref_153) 2020; 130
Barton (ref_87) 1999; 274
Wang (ref_147) 2009; 84
Jones (ref_57) 2012; 51
Chua (ref_81) 1994; 153
Presky (ref_83) 1996; 93
Crabe (ref_22) 2009; 183
Zundler (ref_41) 2015; 26
Ishizaki (ref_102) 2011; 187
Bacon (ref_99) 1995; 92
Yao (ref_120) 1999; 368
Kobayashi (ref_10) 1989; 170
Floss (ref_3) 2019; 47
(ref_2) 2018; 10
Ramnath (ref_15) 2015; 93
Croxford (ref_34) 2014; 25
Perret (ref_86) 2003; 278
Ohnuki (ref_72) 2016; 9
Khader (ref_33) 2019; 202
Huber (ref_145) 2008; 93
Desmet (ref_154) 2014; 5
Soendergaard (ref_152) 2018; 192
Garbers (ref_26) 2013; 288
Zhong (ref_148) 2018; 14
Jalah (ref_53) 2013; 288
Park (ref_142) 2016; 37
Jana (ref_66) 2009; 127
Moschen (ref_35) 2019; 16
Takaku (ref_141) 2009; 88
Zhu (ref_146) 2020; 69
Floss (ref_28) 2017; 7
Jones (ref_74) 2011; 51
Neubauer (ref_107) 1998; 93
Spangler (ref_1) 2015; 33
Heinzel (ref_52) 1997; 158
ref_56
Ivanov (ref_97) 2006; 126
Chyuan (ref_42) 2020; 175
Villarino (ref_100) 2017; 18
Sayago (ref_84) 2018; 9
Pettersen (ref_131) 2004; 25
Floss (ref_112) 2013; 288
Hummel (ref_79) 2017; 37
Esch (ref_90) 2020; 295
Scheller (ref_29) 2015; 26
Gillessen (ref_60) 1995; 25
Nishikomori (ref_118) 2002; 169
Sivanesan (ref_140) 2016; 291
Zheng (ref_98) 2016; 941
Pradhan (ref_125) 2007; 104
Kleinsteuber (ref_127) 2012; 120
Cua (ref_30) 2003; 421
Wang (ref_7) 2012; 287
Devergne (ref_19) 1997; 94
Engelowski (ref_129) 2018; 8
Zhang (ref_32) 2003; 171
Welsby (ref_93) 2016; 941
Momozawa (ref_137) 2011; 43
Magyari (ref_136) 2007; 67
Flores (ref_8) 2015; 45
Wong (ref_43) 2019; 28
Sinclair (ref_151) 2019; 15
Hasegawa (ref_27) 2016; 7
Vignali (ref_75) 2012; 13
Engelowski (ref_124) 2018; 9
Ultsch (ref_78) 1992; 255
Jana (ref_67) 2009; 57
Chen (ref_133) 2010; 49
Collison (ref_76) 2012; 13
Murakami (ref_5) 2019; 50
ref_115
ref_114
Hunter (ref_6) 2019; 50
Jeon (ref_45) 2017; 13
Egwuagu (ref_49) 2015; 26
Paonessa (ref_85) 1995; 14
Ye (ref_36) 2020; 11
Beyer (ref_69) 2008; 382
Zhu (ref_95) 2018; 10
(ref_126) 2008; 45
Bridgewood (ref_17) 2019; 68
ref_38
Lee (ref_61) 2015; 195
Hong (ref_139) 2019; 7
Zhang (ref_31) 2003; 170
Stern (ref_12) 1990; 87
Floss (ref_105) 2016; 27
Babon (ref_109) 2014; 26
Ciapponi (ref_88) 1995; 270
Cho (ref_116) 2006; 176
Mattner (ref_59) 1993; 23
Sieper (ref_39) 2019; 15
Yoshimura (ref_108) 2018; 10
Wu (ref_117) 2000; 165
Du (ref_149) 2020; 210
Anhuf (ref_111) 2000; 165
Morris (ref_110) 2018; 27
Neurath (ref_40) 2019; 45
Kumar (ref_130) 2009; 4
Meier (ref_71) 2019; 10
ref_4
References_xml – volume: 50
  start-page: 812
  year: 2019
  ident: ref_5
  article-title: Pleiotropy and specificity: Insights from the Interleukin 6 family of cytokines
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.027
  contributor:
    fullname: Murakami
– volume: 146
  start-page: 3074
  year: 1991
  ident: ref_11
  article-title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.146.9.3074
  contributor:
    fullname: Wolf
– volume: 22
  start-page: 237
  year: 2015
  ident: ref_48
  article-title: New insights into IL-12-mediated tumor suppression
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2014.134
  contributor:
    fullname: Tugues
– volume: 158
  start-page: 4381
  year: 1997
  ident: ref_52
  article-title: In vivo production and function of IL-12 p40 homodimers
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.158.9.4381
  contributor:
    fullname: Heinzel
– volume: 51
  start-page: 234
  year: 2012
  ident: ref_57
  article-title: Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2012.03.025
  contributor:
    fullname: Jones
– volume: 165
  start-page: 2535
  year: 2000
  ident: ref_111
  article-title: Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: Structural receptor requirements for signal attenuation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.165.5.2535
  contributor:
    fullname: Anhuf
– volume: 62
  start-page: 195
  year: 2013
  ident: ref_135
  article-title: Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-012-0566-z
  contributor:
    fullname: Safrany
– volume: 288
  start-page: 4346
  year: 2013
  ident: ref_26
  article-title: An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.432955
  contributor:
    fullname: Garbers
– volume: 10
  start-page: a028571
  year: 2018
  ident: ref_108
  article-title: Negative regulation of cytokine signaling in immunity
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a028571
  contributor:
    fullname: Yoshimura
– volume: 88
  start-page: 653
  year: 2009
  ident: ref_141
  article-title: Interleukin-23 receptor (IL-23R) gene polymorphisms in acquired aplastic anemia
  publication-title: Ann. Hematol.
  doi: 10.1007/s00277-008-0666-6
  contributor:
    fullname: Takaku
– volume: 93
  start-page: 1077
  year: 2008
  ident: ref_145
  article-title: Interleukin (IL)-23 receptor is a major susceptibility gene for Graves’ ophthalmopathy: The IL-23/T-helper 17 axis extends to thyroid autoimmunity
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2007-2190
  contributor:
    fullname: Huber
– volume: 117
  start-page: 22
  year: 2006
  ident: ref_62
  article-title: The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects
  publication-title: J. Immunol.
  doi: 10.1111/j.1365-2567.2005.02257.x
  contributor:
    fullname: Shimozato
– volume: 57
  start-page: 1553
  year: 2009
  ident: ref_67
  article-title: IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1
  publication-title: Glia
  doi: 10.1002/glia.20869
  contributor:
    fullname: Jana
– volume: 16
  start-page: 185
  year: 2019
  ident: ref_35
  article-title: IL-12, IL-23 and IL-17 in IBD: Immunobiology and therapeutic targeting
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0084-8
  contributor:
    fullname: Moschen
– volume: 45
  start-page: 1
  year: 2019
  ident: ref_40
  article-title: IL-23 in inflammatory bowel diseases and colon cancer
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2018.12.002
  contributor:
    fullname: Neurath
– volume: 43
  start-page: 43
  year: 2011
  ident: ref_137
  article-title: Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
  publication-title: Nat. Med.
  doi: 10.1038/ng.733
  contributor:
    fullname: Momozawa
– volume: 202
  start-page: 629
  year: 2019
  ident: ref_33
  article-title: The tale of IL-12 and IL-23: A paradigm shift
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1801603
  contributor:
    fullname: Khader
– volume: 130
  start-page: 1093
  year: 2012
  ident: ref_134
  article-title: Potentially functional polymorphisms in IL-23 receptor and risk of esophageal cancer in a Chinese population
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.26130
  contributor:
    fullname: Chu
– volume: 36
  start-page: 115
  year: 2016
  ident: ref_47
  article-title: Immunology of Multiple Sclerosis
  publication-title: Semin. Neurol.
  doi: 10.1055/s-0036-1579739
  contributor:
    fullname: Sospedra
– volume: 183
  start-page: 7539
  year: 2009
  ident: ref_101
  article-title: Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0902740
  contributor:
    fullname: Oyamada
– volume: 16
  start-page: 779
  year: 2002
  ident: ref_18
  article-title: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
  publication-title: Immunity
  doi: 10.1016/S1074-7613(02)00324-2
  contributor:
    fullname: Pflanz
– volume: 10
  start-page: 4121
  year: 2019
  ident: ref_71
  article-title: The molecular basis of chaperone-mediated interleukin 23 assembly control
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12006-x
  contributor:
    fullname: Meier
– volume: 13
  start-page: 290
  year: 2012
  ident: ref_76
  article-title: The composition and signaling of the IL-35 receptor are unconventional
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2227
  contributor:
    fullname: Collison
– volume: 94
  start-page: 12041
  year: 1997
  ident: ref_19
  article-title: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
  publication-title: Proc. Natl. Acad. Sci. USA.
  doi: 10.1073/pnas.94.22.12041
  contributor:
    fullname: Devergne
– volume: 155
  start-page: 4286
  year: 1995
  ident: ref_82
  article-title: Cloning and characterization of a mouse IL-12 receptor-beta component
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.155.9.4286
  contributor:
    fullname: Chua
– volume: 67
  start-page: 248
  year: 2007
  ident: ref_136
  article-title: Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis
  publication-title: Ann. Rheum. Dis.
  contributor:
    fullname: Magyari
– volume: 148
  start-page: 3433
  year: 1992
  ident: ref_14
  article-title: Cloning and expression of murine IL-12
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.148.11.3433
  contributor:
    fullname: Schoenhaut
– volume: 300
  start-page: 2101
  year: 2003
  ident: ref_73
  article-title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
  publication-title: Science
  doi: 10.1126/science.1083901
  contributor:
    fullname: Boulanger
– volume: 29
  start-page: 2007
  year: 1999
  ident: ref_91
  article-title: Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits
  publication-title: Eur. J. Immunol.
  doi: 10.1002/(SICI)1521-4141(199906)29:06<2007::AID-IMMU2007>3.0.CO;2-0
  contributor:
    fullname: Wang
– volume: 168
  start-page: 5699
  year: 2002
  ident: ref_50
  article-title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.168.11.5699
  contributor:
    fullname: Parham
– ident: ref_4
– volume: 104
  start-page: 18502
  year: 2007
  ident: ref_125
  article-title: Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0702388104
  contributor:
    fullname: Pradhan
– ident: ref_138
  doi: 10.1371/journal.pone.0137801
– volume: 7
  start-page: 15172
  year: 2017
  ident: ref_28
  article-title: IL-6/IL-12 cytokine receptor shuffling of extra- and intracellular domains reveals canonical STAT activation via synthetic IL-35 and IL-39 signaling
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-15173-3
  contributor:
    fullname: Floss
– volume: 195
  start-page: 3001
  year: 2015
  ident: ref_61
  article-title: IL-12p40 homodimer ameliorates experimental autoimmune arthritis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1500400
  contributor:
    fullname: Lee
– ident: ref_56
  doi: 10.1371/journal.pone.0107990
– volume: 126
  start-page: 1121
  year: 2006
  ident: ref_97
  article-title: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.035
  contributor:
    fullname: Ivanov
– volume: 153
  start-page: 128
  year: 1994
  ident: ref_81
  article-title: Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.153.1.128
  contributor:
    fullname: Chua
– volume: 26
  start-page: 587
  year: 2015
  ident: ref_49
  article-title: Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2015.07.013
  contributor:
    fullname: Egwuagu
– volume: 169
  start-page: 4388
  year: 2002
  ident: ref_118
  article-title: Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.169.8.4388
  contributor:
    fullname: Nishikomori
– volume: 49
  start-page: 862
  year: 2010
  ident: ref_133
  article-title: A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20661
  contributor:
    fullname: Chen
– volume: 291
  start-page: 8673
  year: 2016
  ident: ref_140
  article-title: IL23R (Interleukin 23 receptor) variants protective against inflammatory bowel diseases (IBD) display loss of function due to impaired protein stability and intracellular trafficking
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M116.715870
  contributor:
    fullname: Sivanesan
– volume: 421
  start-page: 744
  year: 2003
  ident: ref_30
  article-title: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
  publication-title: Nature
  doi: 10.1038/nature01355
  contributor:
    fullname: Cua
– volume: 171
  start-page: 4485
  year: 2003
  ident: ref_32
  article-title: Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.171.9.4485
  contributor:
    fullname: Zhang
– volume: 19
  start-page: 69
  year: 2020
  ident: ref_44
  article-title: The impact of the interleukin 12/23 inhibitor ustekinumab on the risk of infections in patients with psoriatic arthritis
  publication-title: Expert Opin. Drug Saf.
  doi: 10.1080/14740338.2020.1703946
  contributor:
    fullname: Zabotti
– volume: 450
  start-page: 566
  year: 2007
  ident: ref_20
  article-title: The inhibitory cytokine IL-35 contributes to regulatory T-cell function
  publication-title: Nature
  doi: 10.1038/nature06306
  contributor:
    fullname: Collison
– ident: ref_38
  doi: 10.3390/v11090772
– volume: 19
  start-page: 3530
  year: 2000
  ident: ref_51
  article-title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
  publication-title: EMBO J.
  doi: 10.1093/emboj/19.14.3530
  contributor:
    fullname: Yoon
– volume: 14
  start-page: 1942
  year: 1995
  ident: ref_85
  article-title: Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling
  publication-title: EMBO J.
  doi: 10.1002/j.1460-2075.1995.tb07186.x
  contributor:
    fullname: Paonessa
– volume: 27
  start-page: 2301
  year: 2016
  ident: ref_105
  article-title: Defining the functional binding sites of interleukin 12 receptor beta1 and interleukin 23 receptor to Janus kinases
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E14-12-1645
  contributor:
    fullname: Floss
– volume: 310
  start-page: 1188
  year: 2003
  ident: ref_121
  article-title: SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2003.09.140
  contributor:
    fullname: Yamamoto
– volume: 4
  start-page: 1073
  year: 2009
  ident: ref_130
  article-title: Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.86
  contributor:
    fullname: Kumar
– volume: 28
  start-page: 473
  year: 2019
  ident: ref_43
  article-title: Expert opinion on interleukin-12/23 and interleukin-23 antagonists as potential therapeutic options for the treatment of inflammatory bowel disease
  publication-title: Expert Opin. Investig. Drugs
  doi: 10.1080/13543784.2019.1597053
  contributor:
    fullname: Wong
– volume: 93
  start-page: 397
  year: 1998
  ident: ref_107
  article-title: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81168-X
  contributor:
    fullname: Neubauer
– volume: 254
  start-page: 821
  year: 1991
  ident: ref_77
  article-title: Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
  publication-title: Science
  doi: 10.1126/science.1948064
  contributor:
    fullname: Cunningham
– volume: 10
  start-page: a030338
  year: 2018
  ident: ref_95
  article-title: T helper cell differentiation, heterogeneity, and plasticity
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a030338
  contributor:
    fullname: Zhu
– volume: 25
  start-page: 1605
  year: 2004
  ident: ref_131
  article-title: UCSF Chimera—A visualization system for exploratory research and analysis
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
  contributor:
    fullname: Pettersen
– volume: 941
  start-page: 167
  year: 2016
  ident: ref_93
  article-title: Regulation of Interleukin-23 expression in health and disease
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-94-024-0921-5_8
  contributor:
    fullname: Welsby
– volume: 130
  start-page: 1863
  year: 2020
  ident: ref_153
  article-title: TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI126567
  contributor:
    fullname: Gracey
– volume: 92
  start-page: 7307
  year: 1995
  ident: ref_99
  article-title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.16.7307
  contributor:
    fullname: Bacon
– volume: 368
  start-page: 147
  year: 1999
  ident: ref_120
  article-title: Direct interaction of STAT4 with the IL-12 receptor
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.1999.1302
  contributor:
    fullname: Yao
– volume: 15
  start-page: 5
  year: 2019
  ident: ref_151
  article-title: Tildrakizumab for the treatment of psoriasis
  publication-title: Expert Rev. Clin. Immunol.
  doi: 10.1080/1744666X.2019.1544493
  contributor:
    fullname: Sinclair
– volume: 10
  start-page: a028415
  year: 2018
  ident: ref_2
  article-title: Interleukin-6 family cytokines
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a028415
– ident: ref_92
  doi: 10.1371/journal.pone.0089092
– volume: 176
  start-page: 5652
  year: 2006
  ident: ref_116
  article-title: STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.176.9.5652
  contributor:
    fullname: Cho
– volume: 87
  start-page: 6808
  year: 1990
  ident: ref_12
  article-title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.87.17.6808
  contributor:
    fullname: Stern
– volume: 11
  start-page: 129
  year: 2020
  ident: ref_36
  article-title: Roles and mechanisms of Interleukin-12 family members in cardiovascular diseases: Opportunities and challenges
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00129
  contributor:
    fullname: Ye
– volume: 9
  start-page: 2034
  year: 2018
  ident: ref_124
  article-title: Synthetic cytokine receptors transmit biological signals using artificial ligands
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04454-8
  contributor:
    fullname: Engelowski
– volume: 33
  start-page: 139
  year: 2015
  ident: ref_1
  article-title: Insights into cytokine-receptor interactions from cytokine engineering
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120211
  contributor:
    fullname: Spangler
– volume: 80
  start-page: 273
  year: 2007
  ident: ref_144
  article-title: A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/511051
  contributor:
    fullname: Cargill
– volume: 5
  start-page: 5237
  year: 2014
  ident: ref_154
  article-title: Structural basis of IL-23 antagonism by an Alphabody protein scaffold
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6237
  contributor:
    fullname: Desmet
– volume: 314
  start-page: 1461
  year: 2006
  ident: ref_143
  article-title: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
  publication-title: Science
  doi: 10.1126/science.1135245
  contributor:
    fullname: Duerr
– ident: ref_150
  doi: 10.1371/journal.pone.0025038
– volume: 170
  start-page: 827
  year: 1989
  ident: ref_10
  article-title: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.170.3.827
  contributor:
    fullname: Kobayashi
– volume: 25
  start-page: 415
  year: 2014
  ident: ref_34
  article-title: IL-12-and IL-23 in health and disease
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2014.07.017
  contributor:
    fullname: Croxford
– volume: 25
  start-page: 200
  year: 1995
  ident: ref_60
  article-title: Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.1830250133
  contributor:
    fullname: Gillessen
– volume: 28
  start-page: 33
  year: 2007
  ident: ref_58
  article-title: IL-12p40: An inherently agonistic cytokine
  publication-title: Trends. Immunol.
  doi: 10.1016/j.it.2006.11.002
  contributor:
    fullname: Cooper
– volume: 9
  start-page: 912
  year: 2018
  ident: ref_84
  article-title: Deciphering binding interactions of IL-23R with HDX-MS: Mapping protein and macrocyclic dodecapeptide ligands
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/acsmedchemlett.8b00255
  contributor:
    fullname: Sayago
– volume: 210
  start-page: 108250
  year: 2020
  ident: ref_149
  article-title: The association between genetic polymorphisms of interleukin 23 receptor gene and the risk of rheumatoid arthritis: An updated meta-analysis
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2019.108250
  contributor:
    fullname: Du
– volume: 93
  start-page: 771
  year: 2015
  ident: ref_15
  article-title: TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
  publication-title: Immunol Cell. Biol.
  doi: 10.1038/icb.2015.77
  contributor:
    fullname: Ramnath
– volume: 288
  start-page: 6763
  year: 2013
  ident: ref_53
  article-title: The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: Implications for improved IL-12 cytokine production
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.436675
  contributor:
    fullname: Jalah
– volume: 84
  start-page: 399
  year: 2009
  ident: ref_147
  article-title: Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2009.01.026
  contributor:
    fullname: Wang
– volume: 50
  start-page: 851
  year: 2019
  ident: ref_6
  article-title: The Immunobiology of the Interleukin-12 family: Room for discovery
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.011
  contributor:
    fullname: Hunter
– volume: 13
  start-page: 722
  year: 2012
  ident: ref_75
  article-title: IL-12 family cytokines: Immunological playmakers
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2366
  contributor:
    fullname: Vignali
– volume: 10
  start-page: 44
  year: 2019
  ident: ref_103
  article-title: The TYK2-P1104A autoimmune protective variant limits coordinate signals required to generate specialized T cell subsets
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00044
  contributor:
    fullname: Gorman
– volume: 255
  start-page: 306
  year: 1992
  ident: ref_78
  article-title: Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
  publication-title: Science
  doi: 10.1126/science.1549776
  contributor:
    fullname: Ultsch
– volume: 68
  start-page: 423
  year: 2019
  ident: ref_17
  article-title: The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-019-01235-x
  contributor:
    fullname: Bridgewood
– volume: 47
  start-page: 1
  year: 2019
  ident: ref_3
  article-title: Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2019.05.007
  contributor:
    fullname: Floss
– volume: 170
  start-page: 2153
  year: 2003
  ident: ref_31
  article-title: Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.170.4.2153
  contributor:
    fullname: Zhang
– volume: 307
  start-page: R1216
  year: 2014
  ident: ref_155
  article-title: Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00540.2013
  contributor:
    fullname: Quiniou
– volume: 26
  start-page: 13
  year: 2014
  ident: ref_109
  article-title: Inhibition of IL-6 family cytokines by SOCS3
  publication-title: Semin. Immunol.
  doi: 10.1016/j.smim.2013.12.004
  contributor:
    fullname: Babon
– volume: 270
  start-page: 31249
  year: 1995
  ident: ref_88
  article-title: Definition of a composite binding site for gp130 in human interleukin-6
  publication-title: J Biol. Chem.
  doi: 10.1074/jbc.270.52.31249
  contributor:
    fullname: Ciapponi
– volume: 165
  start-page: 6221
  year: 2000
  ident: ref_117
  article-title: IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.165.11.6221
  contributor:
    fullname: Wu
– volume: 257
  start-page: 400
  year: 1999
  ident: ref_106
  article-title: Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1999.0479
  contributor:
    fullname: Yamamoto
– volume: 163
  start-page: 2902
  year: 1999
  ident: ref_64
  article-title: A novel function of IL-12p40 as a chemotactic molecule for macrophages
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.163.5.2902
  contributor:
    fullname: Ha
– volume: 7
  start-page: 479
  year: 2016
  ident: ref_27
  article-title: Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2016.00479
  contributor:
    fullname: Hasegawa
– volume: 51
  start-page: 5
  year: 2011
  ident: ref_74
  article-title: Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily
  publication-title: Immunol. Res.
  doi: 10.1007/s12026-011-8209-y
  contributor:
    fullname: Jones
– volume: 272
  start-page: 6073
  year: 1997
  ident: ref_104
  article-title: Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.9.6073
  contributor:
    fullname: Zou
– ident: ref_114
  doi: 10.1371/journal.pbio.3000646
– volume: 941
  start-page: 117
  year: 2016
  ident: ref_98
  article-title: Regulation of Interleukin-12 production in antigen-presenting cells
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-94-024-0921-5_6
  contributor:
    fullname: Zheng
– volume: 152
  start-page: S31
  year: 2017
  ident: ref_156
  article-title: The biomarker profile of PTG-200, an oral peptide antagonist of IL-23 receptor, tracks with efficacy in a preclinical model of IBD
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(17)30471-7
  contributor:
    fullname: Cheng
– volume: 290
  start-page: 359
  year: 2015
  ident: ref_68
  article-title: Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor beta1 via site II and induces p19/interleukin 23 receptor interaction via site III
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.617597
  contributor:
    fullname: Schroder
– volume: 288
  start-page: 19386
  year: 2013
  ident: ref_112
  article-title: Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.432153
  contributor:
    fullname: Floss
– volume: 26
  start-page: 471
  year: 2015
  ident: ref_29
  article-title: “Family reunion”--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2015.07.011
  contributor:
    fullname: Scheller
– ident: ref_115
  doi: 10.3390/cells9092044
– volume: 15
  start-page: 747
  year: 2019
  ident: ref_39
  article-title: The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/s41584-019-0294-7
  contributor:
    fullname: Sieper
– volume: 13
  start-page: 715
  year: 2000
  ident: ref_9
  article-title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)00070-4
  contributor:
    fullname: Oppmann
– volume: 125
  start-page: 2211
  year: 2015
  ident: ref_94
  article-title: Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI78085
  contributor:
    fullname: Burkett
– volume: 69
  start-page: 87
  year: 2020
  ident: ref_146
  article-title: Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn’s disease and ulcerative colitis: Evidence from 41 studies
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-019-01296-y
  contributor:
    fullname: Zhu
– volume: 86
  start-page: 519
  year: 2003
  ident: ref_65
  article-title: Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
  publication-title: J. Neurochem.
  doi: 10.1046/j.1471-4159.2003.01864.x
  contributor:
    fullname: Jana
– volume: 41
  start-page: 185
  year: 2019
  ident: ref_46
  article-title: An emerging role of interleukin-23 in rheumatoid arthritis
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.1080/08923973.2019.1610429
  contributor:
    fullname: Yuan
– volume: 27
  start-page: 1984
  year: 2018
  ident: ref_110
  article-title: The molecular details of cytokine signaling via the JAK/STAT pathway
  publication-title: Protein Sci.
  doi: 10.1002/pro.3519
  contributor:
    fullname: Morris
– volume: 274
  start-page: 1875
  year: 1999
  ident: ref_119
  article-title: Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.4.1875
  contributor:
    fullname: Naeger
– volume: 48
  start-page: 45
  year: 2018
  ident: ref_89
  article-title: Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.12.008
  contributor:
    fullname: Bloch
– volume: 165
  start-page: 240
  year: 2019
  ident: ref_24
  article-title: Revisiting the combinatorial potential of cytokine subunits in the IL-12 family
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2019.03.026
  contributor:
    fullname: Detry
– volume: 13
  start-page: 2247
  year: 2017
  ident: ref_45
  article-title: Monoclonal antibodies inhibiting IL-12, -23, and -17 for the treatment of psoriasis
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2017.1356498
  contributor:
    fullname: Jeon
– volume: 496
  start-page: 513
  year: 2013
  ident: ref_128
  article-title: Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
  publication-title: Nature
  doi: 10.1038/nature11984
  contributor:
    fullname: Wu
– volume: 127
  start-page: 312
  year: 2009
  ident: ref_66
  article-title: Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02985.x
  contributor:
    fullname: Jana
– volume: 183
  start-page: 7692
  year: 2009
  ident: ref_22
  article-title: The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901464
  contributor:
    fullname: Crabe
– volume: 93
  start-page: 14002
  year: 1996
  ident: ref_83
  article-title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.93.24.14002
  contributor:
    fullname: Presky
– volume: 37
  start-page: e00014
  year: 2017
  ident: ref_79
  article-title: Synthetic deletion of the Interleukin 23 receptor (IL-23R) stalk region led to autonomous IL-23R homodimerization and activation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00014-17
  contributor:
    fullname: Hummel
– volume: 295
  start-page: 10478
  year: 2020
  ident: ref_90
  article-title: Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA120.013935
  contributor:
    fullname: Esch
– volume: 192
  start-page: 6028
  year: 2014
  ident: ref_23
  article-title: Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1400159
  contributor:
    fullname: Abdi
– volume: 382
  start-page: 931
  year: 2008
  ident: ref_70
  article-title: The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2008.07.051
  contributor:
    fullname: Lupardus
– volume: 278
  start-page: 27169
  year: 2003
  ident: ref_86
  article-title: Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M303168200
  contributor:
    fullname: Perret
– volume: 7
  start-page: 472
  year: 2019
  ident: ref_139
  article-title: Association of IL23R variants with Crohn’s disease in Korean children
  publication-title: Front. Pediatr.
  doi: 10.3389/fped.2019.00472
  contributor:
    fullname: Hong
– volume: 18
  start-page: 374
  year: 2017
  ident: ref_100
  article-title: Mechanisms and consequences of Jak-STAT signaling in the immune system
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3691
  contributor:
    fullname: Villarino
– volume: 45
  start-page: 3889
  year: 2008
  ident: ref_126
  article-title: IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2008.06.029
– volume: 382
  start-page: 942
  year: 2008
  ident: ref_69
  article-title: Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2008.08.001
  contributor:
    fullname: Beyer
– volume: 292
  start-page: 8073
  year: 2017
  ident: ref_55
  article-title: Assembly-induced folding regulates interleukin 12 biogenesis and secretion
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M117.782284
  contributor:
    fullname: Reitberger
– volume: 187
  start-page: 181
  year: 2011
  ident: ref_102
  article-title: Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1003244
  contributor:
    fullname: Ishizaki
– ident: ref_132
  doi: 10.1186/1471-2334-14-316
– volume: 88
  start-page: 4143
  year: 1991
  ident: ref_13
  article-title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.88.10.4143
  contributor:
    fullname: Gubler
– volume: 171
  start-page: 6866
  year: 2003
  ident: ref_63
  article-title: IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.171.12.6866
  contributor:
    fullname: Russell
– volume: 14
  start-page: 635
  year: 2018
  ident: ref_148
  article-title: Complex role of IL-23R polymorphisms on ankylosing spondylitis: A meta-analysis
  publication-title: Expert Rev. Clin. Immunol.
  doi: 10.1080/1744666X.2018.1491308
  contributor:
    fullname: Zhong
– volume: 154
  start-page: 116
  year: 1995
  ident: ref_21
  article-title: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.154.1.116
  contributor:
    fullname: Ling
– volume: 175
  start-page: 113928
  year: 2020
  ident: ref_42
  article-title: New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2020.113928
  contributor:
    fullname: Chyuan
– volume: 192
  start-page: 100
  year: 2018
  ident: ref_152
  article-title: Targeting JAK-STAT signal transduction in IBD
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2018.07.003
  contributor:
    fullname: Soendergaard
– volume: 37
  start-page: 983
  year: 2016
  ident: ref_142
  article-title: Association of IL23R polymorphism (rs7530511) with intracerebral hemorrhage in Korean population
  publication-title: Neurol. Sci.
  doi: 10.1007/s10072-016-2496-y
  contributor:
    fullname: Park
– volume: 274
  start-page: 5755
  year: 1999
  ident: ref_87
  article-title: Identification of three distinct receptor binding sites of murine interleukin-11
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.9.5755
  contributor:
    fullname: Barton
– volume: 46
  start-page: 1343
  year: 2016
  ident: ref_16
  article-title: A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201546095
  contributor:
    fullname: Wang
– volume: 45
  start-page: 3114
  year: 2015
  ident: ref_8
  article-title: IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201445403
  contributor:
    fullname: Flores
– volume: 103
  start-page: 8137
  year: 2006
  ident: ref_123
  article-title: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0600666103
  contributor:
    fullname: Chen
– volume: 16
  start-page: 405
  year: 2015
  ident: ref_80
  article-title: A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane
  publication-title: Genes Immun.
  doi: 10.1038/gene.2015.22
  contributor:
    fullname: Siupka
– volume: 277
  start-page: 43735
  year: 2002
  ident: ref_122
  article-title: Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M208586200
  contributor:
    fullname: Eyles
– volume: 10
  start-page: a028530
  year: 2018
  ident: ref_37
  article-title: Interleukin (IL)-12 and IL-23 and their conflicting roles in cancer
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a028530
  contributor:
    fullname: Yan
– volume: 8
  start-page: 17078
  year: 2018
  ident: ref_129
  article-title: IL-23R signaling plays no role in myocardial infarction
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35188-8
  contributor:
    fullname: Engelowski
– volume: 9
  start-page: ra28
  year: 2016
  ident: ref_72
  article-title: Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling
  publication-title: Sci. Signal.
  contributor:
    fullname: Ohnuki
– volume: 6
  start-page: 24491
  year: 2016
  ident: ref_113
  article-title: Integrative phosphoproteomics links IL-23R signaling with metabolic adaptation in lymphocytes
  publication-title: Sci. Rep.
  doi: 10.1038/srep24491
  contributor:
    fullname: Lochmatter
– volume: 287
  start-page: 36012
  year: 2012
  ident: ref_7
  article-title: Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.390625
  contributor:
    fullname: Wang
– volume: 292
  start-page: 6644
  year: 2017
  ident: ref_25
  article-title: Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M116.762021
  contributor:
    fullname: Chehboun
– volume: 176
  start-page: 1387
  year: 1992
  ident: ref_54
  article-title: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.176.5.1387
  contributor:
    fullname: Rengaraju
– volume: 27
  start-page: 485
  year: 2009
  ident: ref_96
  article-title: IL-17 and Th17 cells
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.021908.132710
  contributor:
    fullname: Korn
– volume: 23
  start-page: 2202
  year: 1993
  ident: ref_59
  article-title: The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.1830230923
  contributor:
    fullname: Mattner
– volume: 26
  start-page: 559
  year: 2015
  ident: ref_41
  article-title: Interleukin-12: Functional activities and implications for disease
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2015.07.003
  contributor:
    fullname: Zundler
– volume: 120
  start-page: 4374
  year: 2012
  ident: ref_127
  article-title: SOCS3 promotes interleukin-17 expression of human T cells
  publication-title: Blood
  doi: 10.1182/blood-2011-11-392738
  contributor:
    fullname: Kleinsteuber
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Snippet Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the...
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SubjectTerms Amino acid sequence
Autoimmune diseases
Chemical bonds
Clinical trials
Cytokines
Drug delivery
IL-12
IL-12 family cytokines
IL-23
Immune system
Immunosuppressive agents
Inflammation
Interleukin 12
Interleukin 23
Interleukins
Intracellular
Intracellular signalling
Mutation
Observations
Physiological aspects
Protein interaction
Quality control
Review
Signal transduction
signaling
Single-nucleotide polymorphism
Structure
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Title IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions
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https://pubmed.ncbi.nlm.nih.gov/PMC7600943
https://doaj.org/article/eaaf16bbf8c04eec906976fa69521f60
Volume 9
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