Capsid-specific T-cell Responses to Natural Infections With Adeno-associated Viruses in Humans Differ From Those of Nonhuman Primates

• Published in: Molecular therapy Vol. 19; no. 11; pp. 2021 - 2030
• Main Authors: Li, Hua, Lasaro, Marcio O, Jia, Bei, Lin, Shih Wen, Haut, Larissa H, High, Katherine A, Ertl, Hildegund CJ
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2011; Elsevier Limited; Nature Publishing Group
• Subjects: Adeno-associated virus; Adolescent; Adult; Animals; Antigens; Capsid - immunology; Cytokines; Dependovirus - immunology; Hemophilia; Human subjects; Humans; Hypotheses; Immunology; Immunophenotyping; Infections; Lymphocytes; Macaca mulatta; Middle Aged; Original; Parvoviridae Infections - immunology; Primates; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor necrosis factor-TNF; Viruses; Young Adult; United States > US; Texas; Pennsylvania

Hepatic adeno-associated virus serotype 2 (AAV2)-mediated gene transfer failed to achieve sustained transgene product expression in human subjects. We formulated the hypothesis that rejection of AAV-transduced hepatocytes is caused by AAV capsid-specific CD8+ T cells that become reactivated upon gen...