Comparison of Microscopy, Nested-PCR, and Real-Time-PCR Assays Using High-Throughput Screening of Pooled Samples for Diagnosis of Malaria in Asymptomatic Carriers from Areas of Endemicity in Myanmar

• Published in: Journal of clinical microbiology Vol. 52; no. 6; pp. 1838 - 1845
• Main Authors: Wang, Bo, Han, Soe-Soe, Cho, Cho, Han, Jin-Hee, Cheng, Yang, Lee, Seong-Kyun, Galappaththy, Gawrie N. L, Thimasarn, Krongthong, Soe, Myat Thu, Oo, Htet Wai, Kyaw, Myat Phone, Han, Eun-Taek
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.06.2014
• Subjects: Blood - parasitology; Carrier State - diagnosis; High-Throughput Screening Assays; Humans; Malaria - diagnosis; Microscopy - methods; Myanmar; Parasitology; Polymerase Chain Reaction - methods; Real-Time Polymerase Chain Reaction - methods; Sensitivity and Specificity; Myanmar

Asymptomatic infection is an important obstacle for controlling disease in countries where malaria is endemic. Because asymptomatic carriers do not seek treatment for their infections, they can have high levels of gametocytes and constitute a reservoir available for new infection. We employed a samp...