CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity - Jia, Xin-Ming; Tang, Bing; Zhu, Le-Le; Liu, Yan-Hui; Zhao, Xue-Qiang; Gorjestani, Sara; Hsu, Yen-Michael S.; Yang, Long; Guan, Jian-Hong; Xu, Guo-Tong; Lin, Xin (The Journal of experimental medicine, 2014)
Keywords: Animals; beta-Glucans - pharmacology; Candida albicans; Candida albicans - drug effects; Candida albicans - genetics; Candida albicans - immunology; Candidiasis - genetics; Candidiasis - immunology; Candidiasis - metabolism; Candidiasis - mortality; CARD Signaling Adaptor Proteins - genetics; CARD Signaling Adaptor Proteins - metabolism; Enzyme Activation - drug effects; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Fungi - drug effects; Fungi - genetics; Fungi - immunology; Humans; Immunity, Innate; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Mice; Mice, Knockout; Multiprotein Complexes - metabolism; Mycoses - genetics; Mycoses - immunology; Mycoses - metabolism; Mycoses - mortality; NF-kappa B - metabolism; Protein Binding; ras Proteins - genetics; ras Proteins - metabolism; ras-GRF1 - metabolism; Signal Transduction