Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web

Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns. As positive-strand RNA viruses, they each replicate in the cytoplasm of infected cells and induce distinct membranous replication compartments where most, if not all, steps of the v...

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Published inJournal of virology Vol. 88; no. 11; pp. 5907 - 5911
Main Authors Chatel-Chaix, Laurent, Bartenschlager, Ralf
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.06.2014
Subjects
Cytoplasmic Vesicles - ultrastructure
Cytoplasmic Vesicles - virology
Dengue virus
Dengue Virus - physiology
Flaviviridae
Gem
Hepacivirus - physiology
Hepatitis C virus
Humans
Intracellular Membranes - metabolism
Intracellular Membranes - virology
Virus Assembly - physiology
Virus Replication - physiology
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Summary:Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns. As positive-strand RNA viruses, they each replicate in the cytoplasm of infected cells and induce distinct membranous replication compartments where most, if not all, steps of the viral life cycle occur. This Gem briefly reviews the most recent insights into the architecture and functional properties of membranous replication and assembly sites induced by DENV and HCV.
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ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.03404-13