RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies

• Published in: Journal of cell science Vol. 122; no. 17; pp. 3180 - 3189
• Main Authors: El Zein, Loubna, Ait-Lounis, Aouatef, Morlé, Laurette, Thomas, Joëlle, Chhin, Brigitte, Spassky, Nathalie, Reith, Walter, Durand, Bénédicte
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.09.2009; Company of Biologists
• Subjects: Amino Acid Sequence; Animals; Biochemistry, Molecular Biology; Cilia - chemistry; Cilia - physiology; Ciliary Motility Disorders - genetics; Ciliary Motility Disorders - metabolism; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Developmental; Humans; Life Sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular biology; Molecular Sequence Data; Protein Binding; Regulatory Factor X Transcription Factors; Sequence Alignment; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism

Cilia are cellular organelles that play essential physiological and developmental functions in various organisms. They can be classified into two categories, primary cilia and motile cilia, on the basis of their axonemal architecture. Regulatory factor X (RFX) transcription factors have been shown t...