Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application

Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immu...

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Published inBiotechnology and bioprocess engineering Vol. 28; no. 1; pp. 1 - 16
Main Authors Zhang, Lei, Xu, Wen, Ma, Xi, Sun, XiaoJing, Fan, JinBo, Wang, Yang
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Biotechnology and Bioengineering 01.02.2023
Springer Nature B.V
한국생물공학회
Subjects
Antibodies
Antigen presentation
Antigens
Antiviral drugs
Biotechnology
Chemical modification
Chemistry
Chemistry and Materials Science
Clinical trials
Cytokines
Cytotoxicity
Epitopes
Genomes
Hepatitis
Immune response
Immune response (humoral)
Immunogenicity
Industrial and Production Engineering
live vaccines
Lymphocytes
Pathogens
Pattern recognition
Proteins
Review Paper
Self-assembly
Stimulators
structural proteins
Surface charge
System effectiveness
T cell receptors
Vaccine development
Vaccines
Viral infections
Virus-like particles
Viruses
생물공학
virus-like particles
antiviral vaccine
viral infection
antigen presentation
immune response
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Abstract Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized.
AbstractList Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized.
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized. KCI Citation Count: 0
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized.Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized.
Author Fan, JinBo
Wang, Yang
Xu, Wen
Ma, Xi
Zhang, Lei
Sun, XiaoJing
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  organization: Xi’an Key Laboratory of Pathogenic Microorganism and Tumor Immunity, Department of Basic Medicine, Xi’an Medical University
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Issue 1
Keywords virus-like particles
antiviral vaccine
viral infection
antigen presentation
immune response
Language English
License The Korean Society for Biotechnology and Bioengineering and Springer 2023.
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Snippet Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective...
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SubjectTerms Antibodies
Antigen presentation
Antigens
Antiviral drugs
Biotechnology
Chemical modification
Chemistry
Chemistry and Materials Science
Clinical trials
Cytokines
Cytotoxicity
Epitopes
Genomes
Hepatitis
Immune response
Immune response (humoral)
Immunogenicity
Industrial and Production Engineering
live vaccines
Lymphocytes
Pathogens
Pattern recognition
Proteins
Review Paper
Self-assembly
Stimulators
structural proteins
Surface charge
System effectiveness
T cell receptors
Vaccine development
Vaccines
Viral infections
Virus-like particles
Viruses
생물공학
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Title Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application
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