Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo

• Published in: International journal of molecular sciences Vol. 17; no. 5; p. 769
• Main Authors: De Freitas, Laura, Calixto, Giovana, Chorilli, Marlus, Giusti, Juçaíra, Bagnato, Vanderlei, Soukos, Nikolaos, Amiji, Mansoor, Fontana, Carla
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 20.05.2016
• Subjects: Adult; Aged; Biofilms - drug effects; Female; Humans; Lactic Acid - administration & dosage; Lactic Acid - chemistry; Male; Methylene Blue - administration & dosage; Methylene Blue - chemistry; Middle Aged; Nanoparticles; Periodontitis - drug therapy; Periodontitis - microbiology; Photochemotherapy - methods; Polyglycolic Acid - administration & dosage; Polyglycolic Acid - chemistry; methylene blue; PLGA; nanoparticles; biofilms; photodynamic therapy; periodontitis

Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP...