The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A

• Published in: The international journal of neuropsychopharmacology Vol. 25; no. 1; pp. 54 - 63
• Main Authors: Ona, Genís, Sampedro, Frederic, Romero, Sergio, Valle, Marta, Camacho, Valle, Migliorelli, Carolina, Mañanas, Miguel Ángel, Antonijoan, Rosa Maria, Puntes, Montserrat, Coimbra, Jimena, Ballester, Maria Rosa, Garrido, Maite, Riba, Jordi
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.01.2022
• Subjects: Adolescent; Adult; Analysis; Cerebral circulation; Cerebral cortex; Child; Diterpenes, Clerodane - pharmacology; Dosage and administration; Double-Blind Method; Electric properties; Electroencephalography; Female; Hallucinogenic drugs; Hallucinogens - pharmacology; Humans; Male; Middle Aged; Opioids; Physiological aspects; Receptors; Receptors, Opioid, kappa - agonists; Regular s; Testing; Young Adult; Spain; hallucinogens; EEG; SPECT; Kappa opioid receptor; opioids; salvinorin-A

Abstract Background The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinori...