G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling

• Published in: The Journal of experimental medicine Vol. 213; no. 10; pp. 1999 - 2018
• Main Authors: Bajrami, Besnik, Zhu, Haiyan, Kwak, Hyun-Jeong, Mondal, Subhanjan, Hou, Qingming, Geng, Guangfeng, Karatepe, Kutay, Zhang, Yu C, Nombela-Arrieta, César, Park, Shin-Young, Loison, Fabien, Sakai, Jiro, Xu, Yuanfu, Silberstein, Leslie E, Luo, Hongbo R
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 19.09.2016
• Subjects: Acute Disease; Animals; Bone Marrow - pathology; Chemokine CXCL2 - metabolism; Chemotaxis; Escherichia coli; Escherichia coli - physiology; Granulocyte Colony-Stimulating Factor - metabolism; Ligands; Lipopolysaccharides; Lung - pathology; Lung Injury - blood; Lung Injury - complications; Lung Injury - microbiology; Lung Injury - pathology; Mice, Inbred C57BL; Neutrophils - pathology; Pneumonia - blood; Pneumonia - complications; Pneumonia - metabolism; Pneumonia - pathology; Receptors, Interleukin-8B - metabolism; Signal Transduction; STAT3 Transcription Factor - metabolism

Cytokine-induced neutrophil mobilization from the bone marrow to circulation is a critical event in acute inflammation, but how it is accurately controlled remains poorly understood. In this study, we report that CXCR2 ligands are responsible for rapid neutrophil mobilization during early-stage acut...