Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

• Published in: Journal of cerebral blood flow and metabolism Vol. 34; no. 5; pp. 737 - 742
• Main Authors: Sena, Emily S, Currie, Gillian L, McCann, Sarah K, Macleod, Malcolm R, Howells, David W
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2014; Sage Publications Ltd; Nature Publishing Group
• Subjects: Animals; Bias; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Meta-Analysis as Topic; Review; Review Literature as Topic; Stroke - drug therapy; Stroke - epidemiology; Translational Research, Biomedical; basic science; Biostatistics; animal models; experimental; acute stroke
• ISSN: 0271-678X; 1559-7016; 1559-7016
• DOI: 10.1038/jcbfm.2014.28

The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatm...