Extraglandular hormonal steroidogenesis in aged rats

• Published in: Journal of steroid biochemistry and molecular biology Vol. 43; no. 8; pp. 1095 - 1098
• Main Authors: Valle, Luisa Dalla, Belvedere, Paola, Simontacchi, Claudia, Colombo, Lorenzo
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01.12.1992; Elsevier Science
• Subjects: 17-Hydroxysteroid Dehydrogenases - metabolism; 20-alpha-Hydroxysteroid Dehydrogenase - metabolism; Aging - metabolism; Animals; Biological and medical sciences; Chromatography, Thin Layer; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - enzymology; Gastrointestinal Tract - metabolism; Male; Multienzyme Complexes - metabolism; Organ Specificity; Pregnenolone - metabolism; Progesterone Reductase - metabolism; Rats; Rats, Wistar; Skin - enzymology; Skin - metabolism; Steroid 17-alpha-Hydroxylase; Steroid hormones. Cholecalciferol derivatives; Steroid Isomerases - metabolism; Testis - enzymology; Testis - metabolism; Vertebrates: endocrinology; Tissue; Vertebrata; Mammalia; Rat; Steroid hormone; Rodentia; Steroidogenesis; Metabolism; In vitro; Age; Pregnenolone

We have examined the metabolism in vitro of [4- 14C]pregnenolone by the following organs of 2.4-year-old rats: submandibular gland, stomach, duodenum, liver, lung, heart, spleen, kidney, skin, prostate, testis and adrenal. All tissues converted pregnenolone to progesterone, the highest yields being...