The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling

• Published in: Journal of virology Vol. 91; no. 3
• Main Author: Best, Sonja M.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.02.2017
• Subjects: Animals; Arthropod Vectors - virology; Arthropoda; Flaviviridae; Flavivirus; Flavivirus - classification; Flavivirus - physiology; Flavivirus Infections - metabolism; Flavivirus Infections - transmission; Flavivirus Infections - virology; Host-Pathogen Interactions; Humans; Interferon Type I - antagonists & inhibitors; Interferon Type I - metabolism; Janus Kinases - metabolism; Minireview; Protein Binding; Signal Transduction; STAT Transcription Factors - metabolism; Structure-Activity Relationship; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Viral Proteins - metabolism; West Nile virus; Zika virus; NS5; interferons; yellow fever virus; antagonism; JAK-STAT; West Nile virus; dengue virus; Zika virus; flavivirus; tick-borne encephalitis virus

The vector-borne flaviviruses cause severe disease in humans on every inhabited continent on earth. Their transmission by arthropods, particularly mosquitoes, facilitates large emergence events such as witnessed with Zika virus (ZIKV) or West Nile virus in the Americas. Every vector-borne flavivirus...