Loss of Tifab , a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

• Published in: The Journal of experimental medicine Vol. 212; no. 11; pp. 1967 - 1985
• Main Authors: Varney, Melinda E., Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P., Meetei, Ruhikanta A., Inoue, Jun-ichiro, Starczynowski, Daniel T.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 19.10.2015
• Subjects: Animals; Apoptosis; Bone Marrow Transplantation; Cell Differentiation; Chromosomes, Human, Pair 5; Hematopoiesis; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs - physiology; NF-kappa B - antagonists & inhibitors; NF-kappa B - physiology; Proteins - genetics; Proteins - physiology; Signal Transduction - physiology; TNF Receptor-Associated Factor 6 - physiology; Toll-Like Receptors - physiology

TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) myelodysplastic syndrome (MDS). Deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cell (HSPC) proportions and altered my...